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Understanding the functional characteristics of naturally acquired antibodies against P. falciparum merozoite antigens is crucial for determining the protective functions of antibodies. Affinity (measured as kd) of naturally acquired antibodies against two key targets of acquired immunity, EBA175 and PfRh2, was determined using Surface Plasmon Resonance (SPR) in a longitudinal survey in Nigeria. A

Thickened flame (TF) model is one of the effective methods to resolve the flame front in turbulent premixed combustion modeling. The multi-step reaction mechanism is becoming increasingly important for combustion simulations such as pollutant formation, ignition and extinction. The effect of TF model on flame structures when coupling with multi-step reaction mechanism was investigated. The simulat

We consider the problem of finding an event-based sampling scheme that optimizes the trade-off between average sampling rate and control performance in a linear-quadratic-Gaussian (LQG) control problem setting with output feedback. Our analysis is based on a recently presented sampled-data controller structure, which remains LQG-optimal for any choice of sampling scheme. We show that optimization

Modification of a fatigue criterion valid for homogeneous multiaxial stress states to account for the beneficial effect of stress gradients is traditionally performed by modifying the stress terms in the fatigue criterion and thereby introducing new parameters that need to be calibrated. Here the stress terms are left unchanged and, instead, the parameters in the fatigue criterion are modified. Th

Within an envisioned circular bio-based economy, a key component is the valorization of biomass wastes and residues into valuable products. If the commonly used method of life-cycle assessment (LCA) is applied to such products, an update and adaptation of LCA practice is needed regarding potentially outdated assumptions of residual resources as free from environmental impact. This paper therefore

The endogenous opioid system (EOS) controls the processing of nociceptive stimuli and is a pharmacological target for opioids. Alterations in expression of the EOS genes under neuropathic pain condition may account for low efficacy of opioid drugs. We here examined whether EOS expression patterns are altered in the lumbar spinal cord of the rats with spinal nerve ligation (SNL) as a neuropathic pa

Objectives: The literature has highlighted the importance of identifying symptoms predictive of acute myocardial infarction (AMI) in women, in addition to traditional cardiovascular risk factors. The objective was to study subjective health problems, in relation to later AMI, in a large sample of women, adjusted for age, educational status, smoking, waist/hip ratio, blood pressure, total cholester

As an effective strategy to control the combustion of advanced combustion modes, the application of variable valve timing (VVT) in reactivity controlled compression ignition (RCCI) combustion was investigated in this study. By coupling KIVA-3V code with genetic algorithm, the combustion of a heavy-duty engine with RCCI combustion combined with VVT strategy was optimized under a wide load range. At

Objective: Investigate the temporal development of EEG and prognosis. Methods: Prospective observational substudy of the Target Temperature Management trial. Six sites performed simplified continuous EEG-monitoring (cEEG) on comatose patients after cardiac arrest, blinded to treating physicians. We determined time-points of recovery of a normal-voltage continuous background activity and the appear

Purpose: To investigate the statistical distribution of the gamma value under error-free conditions, in order to study the relation between the gamma evaluation failure rate and statistically significant deviations in the general situation. Methods: The 2D absorbed dose distribution for 30 clinical head-and-neck IMRT fields were calculated in a QC phantom. For the same fields, dose measurements we

We present the robot developed within the Hobbit project, a socially assistive service robot aiming at the challenge of enabling prolonged independent living of elderly people in their own homes. We present the second prototype (Hobbit PT2) in terms of hardware and functionality improvements following first user studies. Our main contribution lies within the description of all components developed

AIMS: Cardiovascular disease (CVD) is one of the leading causes of mortality and morbidity worldwide, including in Sweden. The main aim of this study was to explore the temporal trends and spatial patterns of CVD in Sweden using spatial autocorrelation analyses.METHODS: The CVD admission rates between 2000 and 2010 throughout Sweden were entered as the input disease data for the analytic processes

Adenosine plays an important role in cell death and differentiation as well as in tumorigenesis and the intra- and extra-cellular levels range from nanomolar to millimolar levels under various physiological or pathophysiological conditions. Here we report that adenosine can activate HPV16 late gene expression in a dose- and time-dependent manner, but only in the presence of guanosine. This activat