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Impacts of smoking on endocrine treatment response in a prospective breast cancer cohort

Background:The association between smoking and breast cancer prognosis remains unclear. The purpose of this study was to investigate whether preoperative smoking was associated with prognosis in different treatment groups.Methods:This population-based cohort consisted of 1065 breast cancer patients without preoperative treatment included between 2002 and 2012 in Lund, Sweden. Smoking status was ex

Implementing a streaming application on a processor array : A case study on the Epiphany architecture

This paper reports on a case study in which an at- size application is ported onto a commercially available processor array. Its purpose is threefold: (1) Determine the suitability of processor arrays for this kind of application. (2) Develop a runtime software infrastructure that supports streaming applications on processor arrays. (3) Gather data and insights into the resulting system performanc

Appendicitis in Children. Clinical, diagnostic and pathogenic factors

Background: Appendicitis is the most common disease requiring abdominal surgery in children. However, the diagnosis of pediatric appendicitis is still a challenge, resulting in perforation and negative appendectomies, especially in girls and young children. Further, the pathogenesis of acute appendicitis is not known. Aim: To examine acute appendicitis in children in the aspects of evaluation of t

Proceedings of the Swedish Orthopedic Society

The Swedish Orthopaedic Society held its meeting on September 10-12,1986, in Östersund, which is situated on a large lake in central Sweden. This year, Ostersund celebrated its bicentennial; but more than 1,000 years ago the Vikings had a center here to worship their gods, as well as a fortress on the neighboring island of Frösö. Today, Östersund is the gateway to Sweden's most popular winter recr

In the quest for economic significance : Assessing variable importance through mean value decomposition

Economic significance is frequently assessed through statistical hypothesis testing, which however, does not always correspond to the implicit economical questions being addressed. In this article we propose using mean value decomposition to assess economic significance. Unlike most previously suggested methods the proposed one is intuitive and simple to conduct. The technique is demonstrated and

Fabrication of poly(3-hexylthiophene) nanowires for high-mobility transistors

Presented here is a novel and efficient method used to improve carrier mobilities of poly(3-hexylthiophene) (P3HT)-based organic field effect transistors by means of nanowire formation. The treatment, termed solvation, consists of depositing a small quantity of a solvent directly on top of a previously deposited semiconducting film, and allowing the solvent to evaporate slowly. Such treatment resu

Deformation mechanisms underlying tension-compression asymmetry in magnesium alloy ZK60 revealed by acoustic emission monitoring

This study is aimed at clarifying the microscopic mechanisms that determine a pronounced asymmetry of plastic deformation with respect to tension and compression in magnesium alloys, even having a random texture. The specific object of the present investigation is the Mg-Zn-Zr alloy ZK60. The mechanisms in question are based on a synergistic interplay between dislocation slip and deformation twinn

STAT5 induces miR-21 expression in cutaneous T cell lymphoma

In cutaneous T cell lymphomas (CTCL), miR-21 is aberrantly expressed in skin and peripheral blood and displays anti-apoptotic properties in malignant T cells. It is, however, unclear exactly which cells express miR-21 and what mechanisms regulate miR-21. Here, we demonstrate miR-21 expression in situ in both malignant and reactive lymphocytes as well as stromal cells. qRT-PCR analysis of 47 patien

High incidence of infective endocarditis in adults with congenital ventricular septal defect

Objective Ventricular septal defects (VSDs), if haemodynamically important, are closed whereas small shunts are left without intervention. The long-term prognosis in congenital VSD is good but patients are still at risk for long-term complications. The aim of this study was to clarify the incidence of infective endocarditis (IE) in adults with VSD. Methods The Swedish registry for congenital heart

Stillbirth and neonatal death among female cancer survivors : A national cohort study

The number of cancer survivors continues to increase worldwide. Many of these survivors have had children of their own. It is less well-known whether radiation therapy or chemotherapy could affect the risk of stillbirth and neonatal death for these children. To explore this research questions, we identified all women diagnosed with cancer between 1958 and 2012 from the Swedish Cancer Register and

Venous thromboembolism does not share familial susceptibility with retinal vascular occlusion or glaucoma : a nationwide family study

Inherited hypercoagulable states (i.e. thrombophilia) have been suggested to be involved in retinal vascular occlusion but results are divergent. Vascular micronutrition and ischemia have been hypothesised to be involved in the pathogenesis of glaucoma. This nationwide study determines the importance of family history of venous thromboembolism (VTE) as a risk factor for retinal vein occlusion (RVO

Probability of combined high sea levels and large rains in Malmö, Sweden, southern Öresund

Observations of sea level and precipitation in Malmö, Sweden in the southeastern part of the sound Öresund have been used to estimate the probabilities of local compound events of high sea level and large daily and hourly rains. There are observations of sea level and daily rains extending back to 1930. The observations of short-term rainfall are from 1980 and onwards. Most large rainfalls come in

Molecular studies on structural changes and oligomerisation of violaxanthin de-epoxidase associated with the pH-dependent activation

Violaxanthin de-epoxidase (VDE) is a conditionally soluble enzyme located in the thylakoid lumen and catalyses the conversion of violaxanthin to antheraxanthin and zeaxanthin, which are located in the thylakoid membrane. These reactions occur when the plant or algae are exposed to saturating light and the zeaxanthin formed is involved in the process of non-photochemical quenching that protects the

Superlattice gain in positive differential conductivity region

We analyze theoretically a superlattice structure proposed by A. Andronov et al. [JETP Lett. 102, 207 (2015)] to give Terahertz gain for an operation point with positive differential conductivity. Here we confirm the existence of gain and show that an optimized structure displays gain above 20 cm-1 at low temperatures, so that lasing may be observable. Comparing a variety of simulations, this gain

A mouse model of the 15q13.3 microdeletion syndrome shows prefrontal neurophysiological dysfunctions and attentional impairment

Rationale: A microdeletion at locus 15q13.3 is associated with high incidence rates of psychopathology, including schizophrenia. A mouse model of the 15q13.3 microdeletion syndrome has been generated (Df[h15q13]/+) with translational utility for modelling schizophrenia-like pathology. Among other deficits, schizophrenia is characterised by dysfunctions in prefrontal cortical (PFC) inhibitory circu

Impact of SPECT corrections on 3D-dosimetry for liver transarterial radioembolization using the patient relative calibration methodology

Purpose: Many centers aim to plan liver transarterial radioembolization (TARE) with dosimetry, even without CT-based attenuation correction (AC), or with unoptimized scatter correction (SC) methods. This work investigates the impact of presence vs absence of such corrections, and limited spatial resolution, on 3D dosimetry for TARE. Methods: Three voxelized phantoms were derived from CT images of

Characteristics and survival of adult Swedish PAH and CTEPH patients 2000–2014

Objectives: The Swedish Pulmonary Arterial Hypertension Register (SPAHR) is an open continuous register, including pulmonary arterial hypertension (PAH) and chronic thromboembolic pulmonary hypertension (CTEPH) patients from 2000 and onwards. We hereby launch the first data from SPAHR, defining baseline characteristics and survival of Swedish PAH and CTEPH patients. Design: Incident PAH and CTEPH