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The relevance of employing a three-perspective view on occupational balance among people with depression and/or anxiety disorders

BACKGROUND: Assessing perceptions of occupational balance is essential in both clinical occupational therapy and research. Attempts to characterise occupational balance often arrive at multi-faceted explanations, including a variety of occupations, personal satisfaction, and time allocation.AIM: This study aimed to deepen the understanding of occupational balance as a phenomenon and investigate th

Pentastatin, a matrikine of the collagen IVα5, is a novel endogenous mediator of pulmonary endothelial dysfunction

Deposition of basement membrane components, such as collagen IVα5, is associated with altered endothelial cell function in pulmonary hypertension. Collagen IVα5 harbors a functionally active fragment within its C-terminal noncollageneous (NC1) domain, called pentastatin, whose role in pulmonary endothelial cell behavior remains unknown. Here, we demonstrate that pentastatin serves as a mediator of

Endothelial Basement Membrane Components and Their Products, Matrikines : Active Drivers of Pulmonary Hypertension?

Pulmonary arterial hypertension (PAH) is a vascular disease that is characterized by elevated pulmonary arterial pressure (PAP) due to progressive vascular remodeling. Extracellular matrix (ECM) deposition in pulmonary arteries (PA) is one of the key features of vascular remodeling. Emerging evidence indicates that the basement membrane (BM), a specialized cluster of ECM proteins underlying the en

New bio- and chemostratigraphic data from southwestern China and its relation to Telychian (Llandovery, Silurian) climate change

Integrated conodont and carbon isotope data is presented from the Telychian (upper Llandovery, lower Silurian) from the Baicaoping section, Yunnan Province, southwestern China. Three conodont zonal units, in stratigraphically ascending order, the Pterospathodus eopennatus Superzone, Pterospathodus celloni Superzone, and the Pterospathodus amorphognathoides amorphognathoides Zone, are recognized in

The basement membrane in the cross-roads between the lung and kidney

The basement membrane (BM) is a specialized layer of extracellular matrix components that plays a central role in maintaining lung and kidney functions. Although the composition of the BM is usually tissue specific, the lung and the kidney preferentially use similar BM components. Unsurprisingly, diseases with BM defects often have severe pulmonary or renal manifestations, sometimes both. Excessiv

Basement membrane remodeling controls endothelial function in idiopathic pulmonary arterial hypertension

The extracellular matrix (ECM) increasingly emerges as an active driver in several diseases, including idiopathic pulmonary arterial hypertension (IPAH). The basement membrane (BM) is a specialized class of ECM proteins. In pulmonary arteries, the BM is in close contact and direct proximity to vascular cells, including endothelial cells. So far, the role of the BM has remained underinvestigated in

Impairment of the NKT–STAT1–CXCL9 Axis Contributes to Vessel Fibrosis in Pulmonary Hypertension Caused by Lung Fibrosis

Rationale: Pulmonary hypertension (PH) is a common, severe comorbidity in interstitial lung diseases such as pulmonary fibrosis (PF), and it has limited treatment options. Excessive vascular fibrosis and inflammation are often present in PH, but the underlying mechanisms are still not well understood. Objectives: To identify a novel functional link between natural killer T (NKT) cell activation an

Effects of copepod chemical cues on intra- and extracellular toxins in two species of Dinophysis

Copepods may contribute to harmful algal bloom formation by selectively rejecting harmful cells. Additionally, copepods and the chemical cues they exude, copepodamides, have been shown to induce increased toxin production in paralytic and amnesic toxin producing microalgae. However, it is unknown if diarrhetic shellfish toxin (DST) producers such as Dinophysis respond to copepods or copepodamides

The role of tool edge geometry on material removal and surface integrity in cutting metal matrix composites

Metal matrix composites (MMCs) possess excellent material properties due to the combination of metals and reinforcing phases, yet this reduces their machinability. Numerous studies have shown that, due to the ploughing effect of the cutting tool, the edge effect can directly impact the material removal mechanism and the generation of surface integrity. However, the influence of different cutting-e

Signal-Averaged ECG in the Diagnostic Workup for Arrhythmogenic Cardiomyopathy : Insights From the Nordic ARVC Registry

BACKGROUND: The diagnostic role of signal-averaged ECG (SAECG) in arrhythmogenic right ventricular cardiomyopathy (ARVC) has lately been questioned. We assessed the value of SAECG-derived late ventricular potentials (LP) in ARVC diagnosis and its association with disease manifestations.METHODS AND RESULTS: Patients with definite ARVC diagnosis or genotype-positive family members who underwent SAEC

Conflicting identities : cosmopolitan or anxious? Appreciating concerns of host country population improves attitudes towards immigrants

This paper connects insights from the literature on cosmopolitan worldviews and the effects of perspective-taking in political science, (intergroup) anxiety in social psychology, and identity economics in a vignette-style experiment. In particular, we asked German respondents about their attitudes towards a Syrian refugee, randomizing components of his description (N = 662). The main treatment des

Design, evaluation, and in vitro–in vivo correlation of self-nanoemulsifying drug delivery systems to improve the oral absorption of exenatide

The ability to predict the absorption of exenatide (Ex), a GLP-1 analogue, after oral dosing to rats in self-nanoemulsifying drug delivery systems (SNEDDS), using in vitro methods, was assessed. Ex was complexed with soybean phosphatidylcholine (SPC) prior to loading into SNEDDS. A design of experiments (DoE) approach was employed to develop SNEDDS incorporating medium-chain triglycerides (MCT), m

From the Rainforest to the Fjords : examining equity in carbon capture and storage climate policy

Carbon capture and storage (CCS) is considered by some to be a critical climate change mitigation technology, and a key element in efforts to limit the global temperature increases in line with the goals of the Paris Agreement. Implementation of CCS in mitigation scenarios assumes that it provides cost-effective emission reductions, and/or can achieve negative emissions when combined with bioenerg

Structures and strategies for retaining an international pediatric cohort from birth : Lessons from The Environmental Determinants of Diabetes in the Young (TEDDY) study

Background: Retention of study participants in observational studies is essential to maintaining the representativeness of the population, minimizing selection bias, and assuring sufficient statistical power. The aim of this report is to describe the structures and strategies used to retain participants in The Environmental Determinants of Diabetes in the Young (TEDDY) Study, an observational stud

Alkane selection as a critical factor in structuring reverse wormlike micelles

Hypothesis: The oil phase controls the persistence length and aqueous channel diameter of reverse wormlike micelles (RWLMs), specifically by tuning the cohesive energy density of alkanes. Experiments: We explore the influence of alkanes with varying chain lengths on the rheological properties, structural parameters, and morphology of RWLMs. To establish a link between the solvent characteristics a

Ampullary composite gangliocytoma/neuroma and neuroendocrine tumor management

Ampullary composite gangliocytoma/neuroma and neuroendocrine tumor (CoGNET), previously called ampullary gangliocytic paragangliomas, is a rare entity, with only few reported cases in the literature. This is a multicentric retrospective cohort study of patients treated with endoscopy or surgery for ampullary CoGNET. A literature review of ampullary CoGNET was also performed. Fifteen patients were

Personality in just a few words : Assessment using natural language processing

Assessment of psychological constructs, such as the Big Five personality traits, has predominantly relied on standardized rating scales. While these scales have advantages, we propose that descriptive word-based responses analyzed with natural language processing (NLP) offer a promising alternative for assessing personality traits. We asked participants (N = 663) to describe either their own perso

Breathlessness dimensions should be evaluated in relation to the level of exertion : A clinical study

Background/aim: Exertional breathlessness is a dominating symptom in cardiorespiratory disease, limiting exercise capacity. Multidimensional measurement has been proposed to capture breathlessness, but it is unknown whether it is useful to differentiate people with abnormal vs normal exertional breathlessness intensity. Methods: This was a secondary analysis of a randomized controlled trial of out

Demystifying AMD SEV Performance Penalty for NFV Deployment

Network Function Virtualization (NFV) has shifted communication networks towards more adaptable software solutions, but this transition raises new security concerns, particularly in public cloud deployments. While Intel’s Software Guard Extensions (SGX) offers a potential remedy, it requires complex application adaptations. This paper investigates AMD’s Secure Encrypted Virtualization (SEV) as an

NeuRAD: Neural Rendering for Autonomous Driving

Neural radiance fields (NeRFs) have gained popularity in the autonomous driving (AD) community. Recent meth-ods show NeRFs' potential for closed-loop simulation, en-abling testing of AD systems, and as an advanced training data augmentation technique. However, existing meth-ods often require long training times, dense semantic su-pervision, or lack generalizability. This, in turn, hinders the appl