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Antimony in brake pads - a carcinogenic component?

Antimony trisulfide (Sb2S3) is used as a lubricant in friction material. X-ray diffraction analysis revealed Sb in 3/3 disc brake pads (range 41,000-46,000 mg/kg) and in 2/2 disc brake dust samples (21,000 and 17,000 mg/kg) from trucks. Considerably lower concentrations were found in drum brake pads (3/5, 59-6400 mg/kg) and in drum brake dust (4/18, 78-2800 mg/kg). Other toxic metals were also det

Increased Rho activation and PKC-mediated smooth muscle contractility in the absence of caveolin-1.

Abstract in UndeterminedCaveolae are omega-shaped membrane invaginations that are abundant in smooth muscle cells. Since many receptors and signaling proteins co-localize with caveolae, these have been proposed to integrate important signaling pathways. The aim of this study was to test whether RhoA/Rho-kinase and protein kinase C (PKC)-mediated Ca2+ sensitization depends on caveolae using caveoli

Low levels of nasal nitric oxide (NO) correlate to impaired mucociliary function in the upper airways

Findings in previous studies have suggested nitric oxide (NO) to be a regulator of mucociliary activity in the upper airways. The aim of the present investigation was to study whether a correlation exists between the nasal NO concentration and mucociliary function in patients suffering from respiratory tract diseases such as chronic sinusitis or recurrent pneumonia. Nasal NO was measured with a ch

Differences in Backbone Dynamics of Two Homologous Bacterial Albumin-binding Modules: Implications for Binding Specificity and Bacterial Adaptation.

Proteins G and PAB are bacterial albumin-binding proteins expressed at the surface of group C and G streptococci and Peptostreptococcus magnus, respectively. Repeated albumin-binding domains, known as GA modules, are found in both proteins. The third GA module of protein G from the group G streptococcal strain G148 (G148-GA3) and the second GA module of protein PAB from P.magnus strain ALB8 (ALB8-

Size and complexity of the nuclear genome of the ectomycorrhizal fungus Paxillus involutus.

The basidiomycete Paxillus involutus is forming ectomycorrhizal symbiosis with a broad range of forest trees. Reassociation kinetics on P. involutus nuclear DNA indicated a haploid genome size of 23Mb including 11% of repetitive DNA. A similar genome size (20Mb) was estimated by genomic reconstruction analysis using three single copy genes. To assess the gene density in the P. involutus genome, a

Variants of the CD40 ligand gene are not associated with increased susceptibility to tuberculosis in West Africa

Evidence for linkage between tuberculosis and human chromosomal region Xq26 has previously been described. The costimulatory molecule CD40 ligand, encoded by TNFSF5 and located at Xq26.3, is a promising positional candidate. Interactions between CD40 ligand and CD40 are involved in the development of humoral- and cell-mediated immunity, as well as the activation of macrophages, which are the prima

Neutron Excitations Across the N=50 Shell Gap in 102In

The structure of In-102 has been investigated by in-beam gamma-spectroscopic methods. Knowledge on the excited states of this nucleus has significantly been extended. Three cascades of transitions were observed to exceed the spin-energy domain spanned by the pig(9/2)(-1)v(d(5/2),g(7/2))(3) configurations. The new high spin states at similar to 4 MeV excitation energy could be assigned to the pig(9

High-resolution infrared study of the nu(11) band of allene

The high-resolution infrared spectrum of allene has been observed in the 280-380 cm(-1) region at a nominal resolution of 0.00125 cm(-1) using the IR beamline at the MAX-1 electron storage ring in Lund. The spectrum shows the bending fundamental of the nu(11) band from which spectroscopic constants for the nu(11) level have been obtained. The accompanying hot band component 2nu(11)(2)-nu(11)(1) ha

A test of models for fungal growth based on metabolic heat rate measurements

This paper presents a test of modelling of fungal growth based on the heat produced by Penicillium roqueforti growing on malt extract agar. Thermal power (heat production rate) of P. roqueforti was measured by isothermal calorimetry at 10, 15, 20, 25 and 30°C. The equivalent diameter of similar colonies growing at 20°C were measured by image analysis. Four predictive equations including time lag w

Topics in multifractal measures, nonparametrics and biostatistics

Popular Abstract in Swedish Denna avhandling består av fyra uppsatser. De två första, som utgör huvuddelen av avhandlingen, behandlar en oväntad koppling mellan kärnskattningar av fördelningar och dimensionsspektra för multifraktala mått. Den tredje uppsatsen presenterar ett helautomatiskt expertsystem för detektering av lungembolier med lungscintigrafi. Den avslutande uppsatsen avhandlar statistiThis thesis consists of four papers. The first two papers, which comprise the main part of the thesis, deal with an unexpected connection between kernel density estimators and dimension spectra for multifractal measures. The third paper presents a fully automated expert system for the diagnosis of pulmonary embolism from ventilation/perfusion scintigraphy. The final paper concerns statistical prop

Increased prevalence of gastrointestinal symptoms associated with impaired quality of life in renal transplant recipients.

Background. Immunosuppressive therapies have been associated with gastrointestinal (GI) side effects, which may impair health-related quality of life (HRQoL). Methods. In this survey, 4,232 renal transplant recipients from Denmark, Finland, Nor-way, and Sweden completed the Short-Form 36 (SF-36) questionnaire and the Gastrointestinal Symptom Rating Scale (GSRS). SF-36 scores were compared with cou

Users on the Agenda - Strategies and Theories

This chapter highlights user perspectives related to the development of ICT and the launching of political strategies to involve users in the IT society. Strategies are discussed in relation to cooperation between technical and social scientists. The author points to the fact that the diffrences between various theoretical understandings of the interaction between technology and social change tend

Phenotypic plasticity in Phragmites australis as a functional response to water depth

We have performed investigations to see if the emergent macrophyte Phragmites australis (Cav.) Trin. ex Steud. exhibits phenotypic plasticity as a response to water depth and if such responses in biomass allocation pattern and morphology are functional responses, improving the performance of the plant. In greenhouse experiments plants were grown in deep or shallow water to evaluate plastic respons