Sökresultat

Filtyp

Din sökning på "*" gav 529814 sökträffar

NF1-mutated melanoma tumors harbor distinct clinical and biological characteristics

In general, melanoma can be considered as a UV-driven disease with an aggressive metastatic course and high mutational load, with only few tumors (acral, mucosal, and uveal melanomas) not induced by sunlight and possessing a lower mutational load. The most commonly activated pathway in melanoma is the mitogen-activated protein kinase (MAPK) pathway. However, the prognostic significance of mutation

Contemporary Scandinavian Cinema between Art and Commerce

With regard to Scandinavian cinema and television, the last decades have been marked by the unexpected international appeal and unforeseen longevity of Scandinavian crime or Nordic noir as it is sometimes labeled. This development has paved the way for ever increasing financial and artistic collaboration within the audiovisual industries, especially among the Scandinavian countries. But it has als

Distal Radius Fractures. Outcome and New Methods of Surgical Treatment

Handledsbrott är den vanligaste frakturen på en akutmottagning. De yngre vuxna patienterna är jämnt fördelade mellan könen men de äldre har en övervikt av kvinnor. Hos de äldre men även i medelåldern uppstår frakturen företrädesvis i ett skelett med olika grad av benskörhet. Frakturen behandlas oftast med gips utan operation men drygt en femtedel opereras. Om felställningen är stor eller om fraktu

A mutation in caspase-9 decreases the expression of BAFFR and ICOS in patients with immunodeficiency and lymphoproliferation

Lymphocyte apoptosis is mainly induced by either death receptor-dependent activation of caspase-8 or mitochondria-dependent activation of caspase-9. Mutations in caspase-8 lead to autoimmunity/lymphoproliferation and immunodeficiency. This work describes a heterozygous H237P mutation in caspase-9 that can lead to similar disorders. H237P mutation was detected in two patients: Pt1 with autoimmunity