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There is a well-documented tension in many nonprofts - particularly those seeking government contracts or working in areas that compete with the private sector - between the institutional logics of business-market and nonproft-mission. This paper presents a case study of a century old Swedish nonproft. It suggests that in the presence of competing hybrid logics, organizational actors respond accor
Background: Severe inflammatory airway diseases are associated with inflammation that does not resolve, leading to structural changes and an overall environment primed for exacerbations. Objective: We sought to identify and inhibit pathways that perpetuate this heightened inflammatory state because this could lead to therapies that allow for a more quiescent lung that is less predisposed to sympto
Aim: Attention-deficit/hyperactivity disorder (ADHD) is the most common diagnosis within child- and adolescent psychiatry. Waiting lists and delayed care are major issues. The aim was to evaluate if standardized care (SC) for assessment and treatment of uncomplicated ADHD would reduce resource utilization and increase satisfaction with preserved improvement within the first year of treatment. Meth
Restraint stresses appear in structural parts which are prevented from adjusting their shape when subjected to e.g. shrinkage or thermal actions. If the restrained stresses are large, cracking might occur, which can affect the durability of the structure. In the case of restraint effects, the reinforcement required in a bridge to limit the crack widths can be difficult to determine, as the magnitu
The complement system plays an important role in varying types of disease, ranging from inflammatory and autoimmune disorders to immune deficiency states. In addition, new settings have emerged where complement analysis is of interest to monitor complement-directed therapy and aid identification of transplant complications. Therefore, it is critical that clinical laboratories offer optimized and t
Massively parallel sequencing (MPS) methods are increasingly applied in forensic casework. However, adequate validation guidelines are lacking. In this work, we describe our in-house validation of the ForenSeq DNA Signature Prep Kit (Verogen) for analysis of ancestry- and phenotype-informative SNPs. We also discuss in-house validation of MPS assays in general terms. When validating the SNP assay,
The need to integrate climate change adaptation (CCA) considerations into disaster risk management (DRM) systems is widely recognised. However, successful integration, and thus the implementation of integrated planning measures, is difficult in practice. To understand and reduce the problems encountered, it is important to investigate systemic challenges. These challenges are rooted in the interac
We present a new algorithm for solving the LPN problem. The algorithm has a similar form as some previous methods, but includes a new key step that makes use of approximations of random words to a nearest codeword in a linear code. It outperforms previous methods for many parameter choices. In particular, we can now solve the (512,18) LPN instance with complexity less than 2 80 operations in expec
An important challenge when coupling two different time dependent problems is to increase parallelization in time. We suggest a multirate Neumann-Neumann waveform relaxation algorithm to solve two heterogeneous coupled heat equations. In order to fix the mismatch produced by the multirate feature at the space-time interface a linear interpolation is constructed. The heat equations are discretized
Understanding the etiology and meaning of behavioral symptomatology in the context of neurologic disease, and choosing the most effective intervention is a vexing task. This introduction summarizes the history of our understanding of the relationship between behavioral symptoms and primary neurologic conditions, and considers the ways in which both psychiatric and neurologic disorders occurring si
We study two-dimensional eigenvalue ensembles close to certain types of singular points in the interior of the droplet. We prove existence of a microscopic density which quickly approaches the equilibrium density, as the distance from the singularity increases beyond the microscopic scale. This kind of asymptotic is used to analyze normal matrix models in [3]. In addition, we obtain here asymptoti
Age-related macular degeneration (AMD) is the most common cause of visual impairment in the developed world. A number of patients experience complex lifelike visual experiences—Charles Bonnet syndrome (CBS). In this systematic review, our aim was to provide an overview of the CBS literature in relation to AMD, to determine the prevalence of CBS in patients with AMD and to provide an overview of as
Direct neuronal reprogramming can be achieved using different approaches: by expressing neuronal transcription factors or microRNAs; and by knocking down neuronal repressive elements. However, there still exists a high variability in terms of the quality and maturity of the induced neurons obtained, depending on the reprogramming strategy employed. Here, we evaluate different long-term culture con
A dominating set of a graph G is a set D⊆ VG such that every vertex in VG- D is adjacent to at least one vertex in D, and the domination number γ(G) of G is the minimum cardinality of a dominating set of G. A set C⊆ VG is a covering set of G if every edge of G has at least one vertex in C. The covering number β(G) of G is the minimum cardinality of a covering set of G. The set of connected graphs
The scientific debate following the initial formulation of the “bad luck” hypothesis in cancer development highlighted how measures based on analysis of variance are inappropriately used for risk communication. The notion of “explained” variance is not only used to quantify randomness, but also to quantify genetic and environmental contribution to disease in heritability coefficients. In this pape
