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Working conditions and workplace health and safety promotion in home care : A mixed-method study from Swedish managers’ perspectives

Today, we can see a trend toward increased psychosocial strain at work among home-care managers and staff. The aim of this study is to describe home care managers' views on their own psychosocial working conditions and on how to promote workplace health and safety in a municipality in northern Sweden. A mixed-methods design was used, including questionnaire and qualitative focus group data. The qu

Optimization, validation, and identification of two reliable antibodies for immunodetection of WNT5A

WNT5A is a secreted, noncanonical WNT signaling protein that has been reported to promote progression of several types of cancer, including oral squamous cell carcinoma. Many WNT5A antibodies are available commercially for immunohistochemistry (IHC) and western blot analysis. Validation of the primary antibodies, however, is often neglected. We characterized antibodies for detecting WNT5A by IHC a

EQ-5D utility, response and drug survival in rheumatoid arthritis patients on biologic monotherapy : A prospective observational study of patients registered in the south Swedish SSATG registry

Objectives Biologic agents have dramatically changed treatment of rheumatoid arthritis (RA). To date only scarce head-To-head data exist especially when the biological therapies are given as monotherapy without concomitant disease modifying drugs (DMARDs). Thus the objective of the current study is to evaluate treatment response of all available biological therapies with special focus on utility (

A general theory of phase noise in transconductor-based harmonic oscillators

We present a rigorous phase noise analysis of a generic harmonic oscillator where the active core can be modeled as a transconductor. Phase noise equations are derived without any specific assumption on the nature of the resonator in the oscillator; furthermore, we provide closed-form 1/f2 phase noise equations when the resonator consists of an arbitrary number of cascaded LC tanks, each tuned at

Detection of Contact Force Transients in Robotic Assembly

A robotic assembly task is usually implemented as a sequence of simple motions, and the transitions between the motions are made when some events occur. These events can usually be detected with thresholds on some signal, but faster response is possible by detecting the transient on that signal. This paper considers the problem of detecting these transients. A force-controlled assembly task is use

Electroencephalography as a prognostic tool after cardiac arrest

Multiple prognostic tools are used to evaluate prognosis for comatose survivors resuscitated after cardiac arrest (CA). Next to the clinical neurologic examination, electroencephalography (EEG) is the most commonly used method to assess prognosis. However, the reliability of EEG has been limited by varying classification systems, interrater variability, and the influence of sedation. Another impor

Follow-up of cardiac arrest survivors : Why, how, and when? a practical approach

Cardiac arrest (CA) survivors may experience cognitive, physical, or emotional problems that can affect their return to everyday activities and quality of life. To improve longterm outcomes, interventions after hospital discharge may be needed. A follow-up plan to identify CA survivors with increased risk of residual cognitive, physical, or emotional problems is important to target interventions a

Interactive effects of obesity and physical fitness on risk of ischemic heart disease

Background/Objectives:Obesity and low physical fitness are known risk factors for ischemic heart disease (IHD), but their interactive effects are unclear. Elucidation of interactions between these common, modifiable risk factors may help inform more effective preventive strategies. We examined interactive effects of obesity, aerobic fitness and muscular strength in late adolescence on risk of IHD

Work disability in newly diagnosed patients with primary sjögren syndrome

Objective. To study longterm work disability and possible predictors in newly diagnosed patients with primary Sjogren syndrome (pSS). Methods. Because we wanted to include only patients with full work availability potential, eligible patients were aged 18-62 years. Fifty-one patients (mean age 46 yrs, range 18-61 yrs, 50 women) diagnosed with pSS between January 2001 and December 2012 were include

Local perceptions of land-use change : Using participatory art to reveal direct and indirect socioenvironmental effects of land acquisitions in Kilombero Valley, Tanzania

In this study, we combine conventional qualitative approaches with a more novel approach, participatory art, to explore local perceptions of land-use change and future aspirations for development in two communities in Kilombero Valley, Tanzania. We concentrate on the effects of large-scale land acquisitions on people and the environment in an ecologically important area. Leasing of land to foreign

Thermoresponsive Polymer Brushes on Organic Microspheres for Biomolecular Separation and Immobilization

A new method is developed to synthesize organic microsphere-supported polymer brushes for affinity separation of saccharides and glycoproteins. In the first step, crosslinked polymer microspheres are synthesized using atom transfer radical polymerization (ATRP). The terminal ATRP initiators on the microspheres are used to graft polymer brushes from propargyl acrylate and N-isopropyl acrylamide. Th

A single-arm, open-label, phase 2 clinical trial evaluating disease response following treatment with BI-505, a human anti-intercellular adhesion molecule-1 monoclonal antibody, in patients with smoldering multiple myeloma

Background: Smoldering multiple myeloma (SMM) is an indolent disease stage, considered to represent the transition phase from the premalignant MGUS (Monoclonal Gammopathy of Undetermined Significance) state towards symptomatic multiple myeloma (MM). Even though this diagnosis provides an opportunity for early intervention, few treatment studies have been done and the current standard of care is ob

Gain-of-function SAMD9L mutations cause a syndrome of cytopenia, immunodeficiency, MDS and neurological symptoms

Several monogenic causes of familial myelodysplastic syndrome (MDS) have recently been identified. We studied two families with cytopenia, predisposition to MDS with chromosome 7 aberrations, immunodeficiency, and progressive cerebellar dysfunction. Genetic studies uncovered heterozygous missense mutations in SAMD9L, a tumor suppressor gene located on chromosome arm 7q. Consistent with a gain-of-f

CRIRES-POP : A library of high resolution spectra in the near-infrared: II. Data reduction and the spectrum of the K giant 10 Leonis

Context. High resolution stellar spectral atlases are valuable resources to astronomy. They are rare in the 1-5 μm region for historical reasons, but once available, high resolution atlases in this part of the spectrum will aid the study of a wide range of astrophysical phenomena. Aims. The aim of the CRIRES-POP project is to produce a high resolution near-infrared spectral library of stars across

Echovirus 6 infects human exocrine and endocrine pancreatic cells and induces pro-inflammatory innate immune response

Human enteroviruses (HEV), especially coxsackievirus serotype B (CVB) and echovirus (E), have been associated with diseases of both the exocrine and endocrine pancreas, but so far evidence on HEV infection in human pancreas has been reported only in islets and ductal cells. This study aimed to investigate the capability of echovirus strains to infect human exocrine and endocrine pancreatic cells.

Withdrawal of life-sustaining therapy after cardiac arrest

An increasing number of patients are successfully resuscitated from cardiac arrest (CA) and subsequently treated in an intensive care unit due to unconsciousness. Approximately half of these patients will die during the first weeks postarrest, typically after a determination of a poor neurologic prognosis and a decision to withdraw life-sustaining therapy (WLST). These decisions are guided by univ

Reduction in cardiometabolic risk factors by a multifunctional diet is mediated via several branches of metabolism as evidenced by nontargeted metabolite profiling approach

Scope: Multifunctional diet (MFD), a diet based on multiple functional concepts and ingredients with anti-inflammatory activity, was previously shown to improve different cardiometabolic risk-associated markers in healthy subjects. Here, we assessed the impact of MFD on plasma metabolome and explored associations of the differential metabolites with clinical parameters, searching for metabolic det

Differentiation of diabetes by pathophysiology, natural history, and prognosis

The American Diabetes Association, JDRF, the European Association for the Study of Diabetes, and the American Association of Clinical Endocrinologists convened a research symposium, "The Differentiation of Diabetes by Pathophysiology, Natural History and Prognosis" on 10-12 October 2015. International experts in genetics, immunology, metabolism, endocrinology, and systems biology discussed genetic