Characterization of IFN Signaling Dysregulation and Functional Role of SARS-CoV-2 Protease PLpro in COVID-19 Pathogenesis
SARS-CoV-2 Antagonism of IFN Signalling Pathways. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of coronavirus disease 2019 (COVID-19). The rapid spread of the virus raised concerns for the major gap in knowledge of infectious viral diseases. Understanding how the virus modulates host innate immune responses is crucial for development of therapeutic strategie