Dopamine D2 receptor SPECT with I-123-IBZM: evaluation of collimator and post-filtering when using model-based compensation-a Monte Carlo study
In I-123-IBZM brainSPECT, the main interest is the activity uptake in the striatum relative to the background, and semi-quantitative techniques using regions of interest are typically used for this purpose. Uncertainties in the measured uptakes can however be a problem due to low contrasts and high noise levels. Like SPECT in general, IBZM SPECT should benefit from reconstruction methods that incl