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Antioxidative protection of dietary bilberry, chokeberry and Lactobacillus plantarum HEAL19 in mice subjected to intestinal oxidative stress by ischemia-reperfusion

Background: Ischemia-reperfusion (I/R) in the intestines is an inflammatory condition which activates leukocytes and reactive oxygen species (ROS) and leads to lipid peroxidation and DNA damage. Bilberry and chokeberry fruits are rich sources of polyphenols which may act as antioxidants and prevent lipid peroxidation. Lactic acid bacteria (LAB) may improve microbial status in the intestines and in

Brain natriuretic peptide is related to diastolic dysfunction whereas urinary albumin excretion rate is related to left ventricular mass in asymptomatic type 2 diabetes patients

Background: The aims of this study were to estimate the prevalence of left ventricular systolic (LVSD) and diastolic (LVDD) dysfunction, and to test if BNP and urinary albumin excretion rate (AER) are related to LVSD, LVD and left ventricular mass (LVM) in asymptomatic type 2 diabetes patients. Methods: Presence of LVSD, LVDD and LVM, determined with echocardiography, was related to levels of BNP

Test av vägledande system i en tunnel

The report outlines the conditions and results of an evacuation experiments performed on 1-3 July 2014 in the Northern Link road tunnel in Stockholm. The aim was mainly to investigate how people can best be led to an opposite tunnel side during escape in a smoke-filled tunnel. The experiment also aimed to quantify the speed at which people move in smoke-filled tunnel environments (i.e. at reduced

Acquisition of Growth-Inhibitory Antibodies against Blood-Stage Plasmodium falciparum

Background: Antibodies that inhibit the growth of blood-stage Plasmodium falciparum may play an important role in acquired and vaccine-induced immunity in humans. However, the acquisition and activity of these antibodies is not well understood. Methods: We tested dialysed serum and purified immunoglobulins from Kenyan children and adults for inhibition of P. falciparum blood-stage growth in vitro

Age at Menarche and Type 2 Diabetes Risk The EPIC-InterAct study

OBJECTIVEYounger age at menarche, a marker of pubertal timing in girls, is associated with higher risk of later type 2 diabetes. We aimed to confirm this association and to examine whether it is explained by adiposity.RESEARCH DESIGN AND METHODSThe prospective European Prospective Investigation into Cancer and Nutrition (EPIC)-InterAct case-cohort study consists of 12,403 incident type 2 diabetes

Evaluation of an Electrically Heated Vest (EHV) Using Thermal Manikin in Cold Environments

We studied the heating efficiency of an electrically heated vest (EHV), its relationship to the microclimate temperature distribution in a three-layer clothing ensemble and the effect of an EHV on the clothing’s total thermal insulation by both theoretical analysis and thermal manikin measurements. The heat losses at different ambient conditions and heating states were recorded and the heating eff

Molecular dynamics of NH3 induced by core-electron excitation

Nuclear motion in the N1s(-1)4a(1)(1) core-excited state of ammonia is investigated by studying the angular anisotropy of fragments produced in the decay of the highly excited molecule and compared with predictions from ab initio calculations. Two different fragmentation channels (H+/NH2+ and H+/NH+/H) reveal complex nuclear dynamics as the excitation photon energy is tuned through the 4a(1) reson

An investigation of the thermo-hydraulic performance of the smooth wavy fin-and-elliptical tube heat exchangers utilizing new type vortex generators

A three-dimensional CFD numerical simulation is successfully carried out on thermo-hydraulic characteristics of a new smooth wavy fin-and-elliptical tube (SWFET) heat exchanger with three new types of vortex generators (VGs), namely - rectangular trapezoidal winglet (RTW), angle rectangular winglet (ARW) and curved angle rectangular winglet (CARW). Several parameters have been examined in this stu

The androgen receptor and stem cell pathways in prostate and bladder cancers (Review)

Bladder cancer is three times more common in men than in women. However, the physiological basis of the male predominance of bladder cancer remains poorly understood. A higher than expected association of prostate and bladder cancers has also been reported which may indicate a common mechanism of carcinogenesis. Consistent with this, androgens and the androgen receptor (AR) play essential roles in

Death causes in breast cancer patients

Background: Due to improved outcomes in breast cancer (BCa), the proportion of affected women dying of other causes has increased. Thus, a better survival of BCa requires knowledge of other causes of death. Materials and methods: Data on the population, cancers, and causes of death were gathered from the nationwide Swedish Family-Cancer Database, enrolling similar to 3.68 million Swedish women. A

Experimental Studies of Advanced Ignition Systems for Lean Burn Natural Gas Engines

One of the greatest challenges for the transport sector today is reducing its environmental impact. This applies especially to the emission aspects, much due to increasingly stringent emissions legislations. Carbon dioxide (CO2) is considered an important greenhouse gas, but also unburned hydrocarbons (HC), nitric oxides (NOx) and soot pose environmental as well as health risks. Compared to diesel

Genetic and epigenetic influence on oxidative phosphorylation, islet function and type 2 diabetes in humans

Popular Abstract in Swedish Diabetes är en grupp av sjukdomar som kännetecknas av förhöjda halter av glukos (socker) i blodet. Förekomsten av diabetes ökar i snabb takt i hela världen. År 2011 var 366 miljoner människor drabbade av diabetes, och denna siffra beräknas till 522 miljoner år 2030 om ingen avgörande åtgärd genomförs. Typ 2 diabetes är den vanligaste formen av diabetes och utgör ungefärThe prevalence of type 2 diabetes (T2D) is increasing worldwide. T2D is a heterogeneous disease caused by a complex interplay between multiple genetic, epigenetic and non-genetic factors. The disease is characterised by impaired insulin secretion from pancreatic β-cells and insulin resistance in peripheral tissues. Mitochondrial ATP production by oxidative phosphorylation (OXPHOS) is known to play

IgG Glycan Hydrolysis Attenuates ANCA-Mediated Glomerulonephritis

Anti-neutrophil cytoplasmic autoantibodies (ANCA) directed against myeloperoxidase (MPO) and proteinase 3 (Pr3) are considered pathogenic in ANCA-associated necrotizing and crescentic glomerulonephritis (NCGN) and vasculitis. Modulation of ANCA IgG glycosylation may potentially reduce its pathogenicity by abolishing Fc receptor mediated activation of leukocytes and complement Here, we investigated