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Glioblastoma (GBM) is the most aggressive form of glioma with a high rate of relapse despite intensive treatment. Tumor recurrence is tightly linked to radio-resistance, which in turn is associated with hypoxia. Here, we discovered a strong link between hypoxia and local complement signaling using publicly available bulk, single-cell, and spatially resolved transcriptomic data from patients with G

Background People living with serious respiratory illness experience a high burden of distressing symptoms. Although opioids are prescribed for symptom management, they generate adverse events, and their benefits are unclear. Methods We examined the efficacy and safety of opioids for symptom management in people with serious respiratory illness. Embase, MEDLINE and the Cochrane Central Register of

The study delves into the production of (multi-) strange hadrons in proton-proton collisions at LHC. Novel observables are proposed to distinguish between Epos4, based on core-corona separation between a thermalised QGP phase and a vacuum phase with global strangeness conservation, and Pythia 8.3, based on microscopic interactions between Lund strings that conserve strangeness locally. Correlation

Family accommodation (FA) is widely-recognised as an important clinical phenomenon in obsessive–compulsive disorder (OCD) and anxiety disorders, and is related to poorer treatment outcomes. However, FA has not been quantitatively explored in Body Dysmorphic Disorder (BDD). The aim of this study was to investigate the patterns and correlates of maternal accommodation in adolescent BDD, and its asso

Background: White noise stimulation has demonstrated efficacy in enhancing working memory in children with ADHD. However, its impact on other executive functions commonly affected by ADHD, such as inhibitory control, remains largely unexplored. This research aims to explore the effects of two types of white noise stimulation on oculomotor inhibitory control in children with ADHD. Method: Memory gu

The limited number of accurate and precise radiometric ages through the ~100 Myr span of the Cambrian and Ordovician impedes reliable age determinations for stage boundaries in these periods. Here, we fill significant gaps in the early Paleozoic chronostratigraphy by providing precise Re-Os time-pins. Sample selection is linked to a firm biostratigraphic framework built on the appearance and distr

This chapter is concerned with Turkish heritage speakers (HSs) in Germany, here exemplified by 21 early bilinguals during adulthood who live in Hamburg, North Germany. We introduce the population, report their self-perceived proficiency and propose the Turkish Use Score (TUS) that is based on quantitative aspects of language use (e.g., the number of people Turkish is spoken with) and qualitative o

In this chapter, we provide a brief introduction to recent work in linguistics that has its origin and motivation in formal linguistics and theoretical acquisition research, and on this basis indicates potential connections and contributions to language pedagogy, including students’ and teachers’ beliefs about what ‘grammar’ actually is.

Mapping in situ eddy covariance measurements of terrestrial land–atmosphere fluxes to the globe is a key method for diagnosing the Earth system from a data-driven perspective. We describe the first global products (called X-BASE) from a newly implemented upscaling framework, FLUXCOM-X, representing an advancement from the previous generation of FLUXCOM products in terms of flexibility and technica

Monitoring the changes of ecosystem functioning is pivotal for understanding the global carbon cycle. Despite its size and contribution to the global carbon cycle, Africa is largely understudied in regard to ongoing changes of its ecosystem functioning and their responses to climate change. One of the reasons is the lack of long-term in situ data. Here, we use eddy covariance to quantify the net e

Current analyses and predictions of spatially explicit patterns and processes in ecology most often rely on climate data interpolated from standardized weather stations. This interpolated climate data represents long-term average thermal conditions at coarse spatial resolutions only. Hence, many climate-forcing factors that operate at fine spatiotemporal resolutions are overlooked. This is particu

The extent and rate of deforestation from 1972 to 1989, including some spatial properties in the heavily polluted mountains of Krusne Hory, on the border between the Czech Republic and Germany were studied. Deforestation was assessed using satellite remote sensing integrated with digital elevation data. The results show that over 50% of the coniferous forest disappeared during this period. Especia

A regression was established according to Wald's method for the estimation of forest productivity in the study area. A correlation of 0.58 was found between productivity (m3sk/ha/year) and TM4/TM3. The 198 compartments which were included in the study were divided into four groups on basis of their productivity. The correlation between observed productivity and estimated productivity was 0.59. The