Objectives To follow up four previously identified classes 'pure axial spondyloarthritis' (axSpA) ('axial'), 'axSpA with peripheral signs' ('inflammatory back pain+peripheral'), 'axSpA at risk' and 'no spondyloarthritis' ('no SpA'). They reflect the expert-opinion-free construct or 'Gestalt' of chronic back pain suspicious of axSpA. The aim was to assess participants' transitions between these cla

Key message: The barley mutant xan-h.chli-1 shows phenotypic features, such as reduced leaf chlorophyll content and daily transpiration rate, typical of wild barley accessions and landraces adapted to arid climatic conditions. Abstract: The pale green trait, i.e. reduced chlorophyll content, has been shown to increase the efficiency of photosynthesis and biomass accumulation when photosynthetic mi

Preamble: Robotic magnetic navigation (RMN)-guided catheter ablation (CA) technology has been used for the treatment of cardiac arrhythmias for almost 20 years. Various studies reported that RMN allows for high catheter stability, improved lesion formation and a superior safety profile. So far, no guidelines or recommendations on RMN-guided CA have been published. Purpose: The aim of this consensu

Genetic analyses were conducted on tumor samples from 88 patients with uveal melanoma (UM), 6 of whom carry pathogenic germline variants in BAP1. We assessed the frequency, pattern, and prognostic significance of somatic aberrations, and investigated differences between germline BAP1 variant carriers compared to sporadic cases. The frequency of the main oncogenic driver mutations was not significa

Background: The diagnosis and treatment of childhood acute lymphoblastic leukemia (ALL) may impact mental health. We investigated the long-term risk of psychiatric disorders among survivors of ALL in a population-based cohort study. Methods: We identified patients diagnosed with ALL in Denmark and Sweden before age 20 during 1982–2008. Survivors of ALL (n = 2026), their siblings (n = 3027), and po

Recent insect decline prompts rapid online monitoring solutions with specificity for thousands of coexisting species.I demonstrate how microscopic and nanoscopic features of insects can aid differentiation of species and be retrieved with spectral lidar.

In a series of papers, we have argued that causal cognition has coevolved with the use of various tools. Animals use tools, but only as extensions of their own bodies, while humans use tools that act at a distance in space and time. This means that we must learn new types of causal mappings between causes and effects. The aim of this article is to account for what is required for such learning of

This article surveys the measurement of historical wealth and income inequality in Germany. We discuss the underlying data sources, the challenges they pose, and the opportunities they create. We also identify two promising avenues for future research. First, we argue that the geographic granularity of German historical statistics provides researchers with the opportunity to investigate the causes

This study analyzes the current state of artificial intelligence (AI) technologies for addressing and mitigating climate change in the manufacturing sector and provides an outlook on future developments. The research is grounded in the concept of general-purpose technologies, motivated by a still limited understanding of innovation patterns for this application context. To this end, we focus on gl

The clinical utility of hemoglobin-based oxygen carriers (HBOC) is limited by adverse heme oxidative chemistry. A variety of tyrosine residues were inserted on the surface of the γ subunit of recombinant fetal hemoglobin to create novel electron transport pathways. This enhanced the ability of the physiological antioxidant ascorbate to reduce ferryl heme and decrease lipid peroxidation. The γL96Y

Consider the quadratic family Ta(x) = ax(1-x) for x ∈ [0, 1] and mixing Collet-Eckmann (CE) parameters a ∈ (2, 4). For bounded φ, set φ˜a := φ-∫ φ dμa, with μa the unique acim of Ta, and put (σa(φ))2 := ∫ φ˜2a dμa + 2Σ i>0 ∫ phi;˜a(φ˜a o T1a) dμa. For any mixing Misiurewicz parameter a∗, we find a positive measure set Ω∗ of mixing CE parameters, containing a∗ as a Lebesgue density point, such that

Northern ecosystems, encompassing boreal forests, tundra, and permafrost areas, are increasingly affected by the amplified impacts of climate change. These ecosystems play a crucial role in determining the global carbon budget. To improve our understanding of carbon uptake in these regions, we evaluate the effectiveness of employing the physically-based Plant Phenology Index (PPI) to estimate gros

In recent years, a vast number of novel antiphage defense mechanisms were uncovered. To facilitate the exploration of mechanistic, ecological, and evolutionary aspects related to antiphage defense systems, we released DefenseFinder in 2021 (Tesson et al., 2022). De-fenseFinder is a bioinformatic program designed for the systematic identification of known antiphage defense mechanisms. The initial r

Diagnosing Alzheimer's disease (AD) poses significant challenges to health care, often resulting in delayed or inadequate patient care. The clinical integration of blood-based biomarkers (BBMs) for AD holds promise in enabling early detection of pathology and timely intervention. However, several critical considerations, such as the lack of consistent guidelines for assessing cognition, limited un

Background and Objectives: Blood services manage the increasingly tight balance between the supply and demand of blood products, and their role in health research is expanding. This review explores the themes that may define the future of blood banking. Materials and Methods: We reviewed the PubMed database for articles on emerging/new blood-derived products and the utilization of blood donors in

Non-invasive prenatal tests (NIPT) to predict fetal red cell or platelet antigen status for alloimmunised women are provided for select antigens. This study reports on massively parallel sequencing (MPS) using a red cell and platelet probe panel targeting multiple nucleotide variants, plus individual identification single nucleotide polymorphisms (IISNPs). Maternal blood samples were provided from

Objective: To evaluate radiographic knee osteoarthritis (OA) progression, development of knee OA, patient-reported outcomes and knee muscle strength at 10-year follow-up after arthroscopic partial meniscectomy (APM) or exercise therapy for degenerative meniscal tears. Methods: Randomised controlled trial including 140 participants, with a degenerative meniscal tear and no or minimal radiographic O

Det här kapitlet fördjupar förståelsen av elevers uppfattningar om läspraktiken shared reading (SR) som ett sätt för dem att utveckla sitt läsengagemang. I kapitlet redovisas en tematisk analys av en fokusgrupp med sju elever i gymnasieskolan som deltagit i sex SR-lektioner inom ramen för SVA1 på ett yrkesprogram. Resultatet relateras till en enkät om deras språkliga bakgrund och läsvanor samt en