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Mutation screening of the BTK gene in 56 families with X-linked agammaglobulinemia (XLA): 47 unique mutations without correlation to clinical course

Objectives. To determine the utility of single-stranded conformation polymorphism (SSCP) analysis for mutation screening in the BTK (Bruton's tyrosine kinase) gene, we investigated 56 X-linked agammaglobulinemia (XLA) families. To obtain genotype/ phenotype correlations, predicted protein aberrations were correlated with the clinical course of the disease. Patients. This study included 56 patients

Search for bosonic stop decays in R-parity violating supersymmetry in e(+)p collisions at HERA

A search for scalar top quarks in R-parity violating supersymmetry is performed in e(+)p collisions at HERA using the H1 detector. The data, taken at roots = 319 GeV and 301 GeV, correspond to an integrated luminosity of 106 pb(-1). The resonant production of scalar top quarks t in positron quark fusion via an R-parity violating Yukawa coupling lambda' is considered with the subsequent bosonic sto

Radial surface segregation in free heterogeneous argon/krypton clusters

Free clusters produced by a co-expansion of argon and krypton have been studied by means of core level photoelectron spectroscopy. In this study we have determined: (i) the produced clusters are heterogeneous; (ii) the radial distribution of the two atomic species in the cluster differs. The proposed structure model places the majority of the krypton atoms in the bulk, leaving the argon atoms to b

Flight costs and fuel composition of a bird migrating in a wind tunnel

We studied the energy and protein balance of a Thrush Nightingale Luscinia luscinia, a small long-distance migrant, during repeated 12-hr long Eights in a wind tunnel and during subsequent two-day fueling periods. From the energy budgets we estimated the power requirements for migratory flight in this 26 g bird at 1.91 Watts. This is low compared to flight cost estimates in birds of similar mass a

On the possibility of using high pressure treatment to modify physico-chemical properties of dietary fibre in white cabbage (Brassica oleracea var. capitata)

The possibility of using high hydrostatic pressure (HHP) to modify the physico-chemical properties of dietary fibre polysaccharides in white cabbage (Brassica oleracea var. capitata) was studied. Two cultivars (Heckla and Predikant) were subjected to high pressure treatment (400 and 500 MPa) at different temperatures (20, 50 and 80 °C). The total dietary fibre (TDF) content was only slightly affec

Vinegar supplementation lowers glucose and insulin responses and increases satiety after a bread meal in healthy subjects

Objective: To investigate the potential of acetic acid supplementation as a means of lowering the glycaemic index (GI) of a bread meal, and to evaluate the possible dose - response effect on postprandial glycaemia, insulinaemia and satiety. Subjects and setting: In all, 12 healthy volunteers participated and the tests were performed at Applied Nutrition and Food Chemistry, Lund University, Sweden.

On the time-domain version of the optical theorem

The time domain version of the optical theorem is discussed. The theorem relates the sum of the scattered and absorbed energies, for a plane pulse that is scattered from a bounded obstacle, to the far field amplitude in the forward direction. Several fundamental results concerning the scattered and absorbed energies that follow from the theorem and from causality are discussed. Some results are ve

Meniscal tear - a feature of osteoarthritis

Meniscectomy is recognized as an important risk factor for the development of knee osteoarthritis (OA), a disease that traditionally has been considered as a simple "wear and tear" phenomenon. However, despite numerous reports, little evidence has been presented that a limited meniscal resection, compared with a more extensive resection, reduces the risk of OA by preserving meniscal function. Why?

Facilitating Transitions to Sustainable Tourism - The role of the tour operator

Popular Abstract in Swedish Turismindustrin är numera en av världens absolut största industrier. Den är av central betydelse för ekonomisk utveckling och arbetstillfällen i ett stort antal länder. Det finns dock en baksida: turism leder ofta till exploatering av miljön, och bidrar i många fall till sociala och kulturella problem. Dagens turismindustri är inte förenlig med hållbar utveckling och deTourism has become a leading industry in the world and continues to grow rapidly, contributing essentially to economic growth and employment in many countries. Tourism as it looks today poses serious threats to the environment and considerable social and cultural challenges. The problem addressed by this research lies in the weakness of current concepts and practices in pursuit of sustainable tour

Actions of platelet-activating factor on isolated feline and human cerebral arteries

The effects of platelet-activating factor (PAF) were studied on isolated feline basilar arteries (BAs) and human pial arteries (PAs). PAF contracted the BAs by 67% of the contraction induced by 124 mM K+ and the PAs by 80%. The contraction in BAs was unaffected by both indomethacin and the thromboxane receptor antagonist AH23848. PAF relaxed prostaglandin F2 alpha-contracted arteries. In BAs 10(-6

Ion and solvent dynamics in gel electrolytes based on ethylene oxide grafted acrylate polymers

Multinuclear pulsed field gradient NMR measurements and theological viscosity measurements were performed on three series of polymer gel electrolytes. The gels were based on a lithium salt electrolyte swollen into a copolymer matrix comprising an acrylate backbone and ethylene oxide side chains. In each series the side chains differed in length and number, but the acrylate-to-ethylene oxide ratio

Nitric oxide exposure diverts neural stem cell fate from neurogenesis towards astrogliogenesis

Regeneration of cells in the central nervous system is a process that might be affected during neurological disease and trauma. Because nitric oxide (NO) and its derivatives are powerful mediators in the inflammatory cascade, we have investigated the effects of pathophysiological concentrations of NO on neurogenesis, gliogenesis, and the expression of proneural genes in primary adult neural stem c

Long-term manipulation of the microbes and microfauna of two subarctic heaths by addition of fungicide, bactericide, carbon and fertilizer

Nutrient availability is a major constraint to plant production and carbon storage in arctic ecosystems, but there are few studies coupling processes in the decomposer and microbial food web and the implications these processes have on the control of nutrient mineralization. We studied the relationship between microbial biomass and the abundance of microbivore and the role of grazing on nutrient t

GDH biosensor based off-line capillary immunoassay for alkylphenols and their ethoxylates

The application of a quinoprotein glucose dehydrogenase modified thick-film sensor as label detector in a capillary immunoassay (CIA) for xenoestrogens is presented. The detection of the alkylphenols and their ethoxylates is based on the competition between the analyte and tracer molecules for the binding sites of anti-alkylphenol ethoxylate antibodies. This assay is performed off-line in small di