Sökresultat

Filtyp

Din sökning på "*" gav 531332 sökträffar

Landscape changes over 30 years of intense economic activity in the upper Paraná River basin

In this study, we show the complexity associated with the recent land cover changes by elucidating the paths of 30 years of changes in the Upper Paraná River Basin (UPRB), a region severely impacted by agricultural activity, one of the areas with the highest density in the production of hydroelectricity, biofuels and food in the world. In this sense, a post-classification comparison approach based

Extended local release and improved bacterial eradication by adding rifampicin to a biphasic ceramic carrier containing gentamicin or vancomycin

AIMS: There is a lack of biomaterial-based carriers for the local delivery of rifampicin (RIF), one of the cornerstone second defence antibiotics for bone infections. RIF is also known for causing rapid development of antibiotic resistance when given as monotherapy. This in vitro study evaluated a clinically used biphasic calcium sulphate/hydroxyapatite (CaS/HA) biomaterial as a carrier for dual d

On the strength of arguments related to standardization in risk management regulations

Risk-informed decision-making is a key concept in regulatory regimes covering a wide range of technical disciplines and risk domains. Increased standardization in terms of highly prescriptive and detailed requirements is observed in various risk management regulations and application areas. This development has spurred a discussion with equally strong voices promoting and opposing standardization

Deep learning algorithm performs similarly to radiologists in the assessment of prostate volume on MRI

ObjectivesProstate volume (PV) in combination with prostate specific antigen (PSA) yields PSA density which is an increasingly important biomarker. Calculating PV from MRI is a time-consuming, radiologist-dependent task. The aim of this study was to assess whether a deep learning algorithm can replace PI-RADS 2.1 based ellipsoid formula (EF) for calculating PV.MethodsEight different measures of PV

Development of a prognostic MRCP score (DiStrict) for patients with large-duct primary sclerosing cholangitis

Background and AimsMRCP is used for diagnosis and follow-up of patients with primary sclerosing cholangitis (PSC). Interest in the prognostic value of MRCP is increasing. The aim of our study is to develop an MRCP-score based on cholangiographic findings previously associated with outcomes and assess its reproducibility and prognostic value in PSC.MethodsThe score (DiStrict-score) was developed ba

Management of mitral stenosis : a systematic review of clinical practice guidelines and recommendations

A number of guidelines exist with recommendations for diagnosis and management of mitral stenosis (MS). We systematically reviewed existing guidelines for diagnosis and management of MS, highlighting their similarities and differences, in order to guide clinical decision-making. We searched national and international guidelines in MEDLINE and EMBASE (5/4/2011-5/9/2021), the Guidelines Internationa

Does Loss of Integrity of the Cingulum Bundle Link Amyloid-β Accumulation and Neurodegeneration in Alzheimer's Disease?

Background: Alzheimer's disease is characterized by the accumulation of amyloid-β (Aβ) into plaques, aggregation of tau into neurofibrillary tangles, and neurodegenerative processes including atrophy. However, there is a poorly understood spatial discordance between initial Aβ deposition and local neurodegeneration. Objective: Here, we test the hypothesis that the cingulum bundle links Aβ depositi

Loneliness, social isolation, and health complaints among older people : A population-based study from the “Good Aging in Skåne (GÅS)” project

Purpose To explore associations between perceived loneliness, social isolation, and health complaints among older people. Methods 5804 participants from the Swedish population study “Good Aging in Skåne” were included. Structured interviews and questionnaires were used to assess perceived loneliness, social isolation, 30 somatic and mental-health related symptoms, socio-demographics, lifestyle, an

Crystal structure of DNA polymerase I from Thermus phage G20c

This study describes the structure of DNA polymerase I from Thermus phage G20c, termed PolI_G20c. This is the first structure of a DNA polymerase originating from a group of related thermophilic bacteriophages infecting Thermus thermophilus, including phages G20c, TSP4, P74-26, P23-45 and phiFA and the novel phage Tth15-6. Sequence and structural analysis of PolI_G20c revealed a 3'-5' exonuclease

Digital Communication and Politics in Aragon. : A two-way communication formula for the interaction between politicians and citizens.

This research presents blogs as an innovative and rich tool for political communication. Blogs can facilitate two-way communication and true interaction between citizens and politicians. The article analyses in depth the content,uses, and characteristics of five weblogs written by Aragonese politicians. Although the study detects some weaknesses in the current political use of blogs, it encourages

Infodemics and health misinformation : a systematic review of reviews

Objective To compare and summarize the literature regarding infodemics and health misinformation, and to identify challenges and opportunities for addressing the issues of infodemics. Methods We searched MEDLINE®, Embase®, Cochrane Library of Systematic Reviews, Scopus and Epistemonikos on 6 May 2022 for systematic reviews analysing infodemics, misinformation, disinformation and fake news related

An Extended Swedish Adoption Study of Anxiety Disorder and Its Cross-Generational Familial Relationship With Major Depression

OBJECTIVE: To clarify, using an extended adoption design, the sources of parent-offspring transmission for anxiety disorder (AD) and its major subforms and their familial cross-generational relationship with major depression (MD). METHODS: Offspring (born 1960-1992) and their parents, from six family types (intact, not-lived-with biological father or mother, lived-with step-father or step-mother,

Ett osteologiskt återbesök till djurbenen från grophusen i Löddeköpinge 90:1 (SU1990)

[utdrag ur rapportens sammanfattning] Denna rapport behandlar djurbenen från grophusen i Löddeköpinge 90:1, vilka grävdes under 1990. Materialet består av 4638 fragment (ca 31 kg) från 28 grophus. Majoriteten kommer från vikingatida grophus. Analysen kan klassas som ett "återbesök" då materialet tidigare studerats av Johansson (2000). Analysen här aktualiseras av att Löddeköpinge kommer ingå i ett

Genealogy making and lineages in postsocialist China : Space, labor, and rituals under processes of heritagization

This photo essay addresses the work and rituals surrounding the making and printing of genealogies in post-socialist China. The essay documents how lineages and printmakers negotiate a new socio-economic environment under the process of heritagization, the materiality and labor of printmaking, and the spaces in which work and rituals takes place. It adds to our understanding of the continuing impo

Webs of World Order : A Relational Theory of Rising Powers and the Evolution of International Order

This dissertation advances a relational theory of rising powers and their influence on international order. The emergence of new great powers and the relative decline of incumbent ones is an inherent feature of world politics. In the modern world, these power transitions have taken place against the background of a core- periphery shaped structure of global relations. Great powers vied for dominan

Tensor-valued diffusion magnetic resonance imaging in a radiotherapy setting

Background and purposeDiagnostic information about cell density variations and microscopic tissue anisotropy can be gained from tensor-valued diffusion magnetic resonance imaging (MRI). These properties of tissue microstructure have the potential to become novel imaging biomarkers for radiotherapy response. However, tensor-valued diffusion encoding is more demanding than conventional encoding, and

Prevalence of potential drug-drug interactions with disease-specific treatments in patients with pulmonary arterial hypertension or chronic thromboembolic pulmonary hypertension : A registry study

Polypharmacy increases the risk of drug-drug interactions that may disturb treatment effects. The aim of this study was to investigate the frequency of codispensing of potentially interacting or contraindicated drugs related to PH-specific treatment in the Swedish pulmonary arterial hypertension (PAH) and chronic thromboembolic pulmonary hypertension (CTEPH) population. All prescribed drugs, on an