The advances in hematopoietic cell transplantation (HCT) over the last decade have led to a transplant-related mortality below 15%. Hepatic sinusoidal obstruction syndrome/veno-occlusive disease (SOS/VOD) is a life-threatening complication of HCT that belongs to a group of diseases increasingly identified as transplant-related, systemic endothelial diseases. In most cases, SOS/VOD resolves within

In this Letter, we have investigated 845 nm lasing generation in atomic oxygen, present in a lean methane-air flame, using two-photon pumping with femtosecond 226 nm laser pulses, particularly focusing on the impact of nanosecond repetitively pulsed glow discharges forcing on the backward lasing signal. Characterizations of the backward lasing pulse, in terms of its spectrum, beam profile, pump pu

We performed a genome-wide association study of total hip replacements, based on variants identified through whole-genome sequencing, which included 4,657 Icelandic patients and 207,514 population controls. We discovered two rare signals that strongly associate with osteoarthritis total hip replacement: a missense variant, c.1141G>C (p.Asp369His), in the COMP gene (allelic frequency = 0.026%, P =

Natural proteins must both fold into a stable conformation and exert their molecular function. To date, computational design has successfully produced stable and atomically accurate proteins by using so-called “ideal” folds rich in regular secondary structures and almost devoid of loops and destabilizing elements, such as cavities. Molecular function, such as binding and catalysis, however, often

Electrical conductivity of fuel microemulsion composed of diesel, pentanol, water, and sucrose laurate as surfactant was investigated over a wide range of water contents varying from 0 to 90 wt% and temperature varying from 10°C to 50°C. Conductivity measurements were performed on samples, the composition of which lie along the one-phase channel using a conductivity meter. Activation energy of con

The groundwater contamination risk in future climates was investigated at three locations in Sweden. Solute transport penetration depths were simulated using the HYDRUS-1D model using historical data and an ensemble of climate projections including two global climate models (GCMs), three emission scenarios and one regional climate model. Most projections indicated increasing precipitation and evap

Diabetes is the leading cause of ESRD. Despite evidence for a substantial heritability of diabetic kidney disease, efforts to identify genetic susceptibility variants have had limited success. We extended previous efforts in three dimensions, examining a more comprehensive set of genetic variants in larger numbers of subjects with type 1 diabetes characterized for a wider range of cross-sectional

The study describes development of a glycan biosensor for detection of a tumor-associated antibody. The glycan biosensor is built on an electrochemically activated/oxidized graphene screen-printed electrode (GSPE). Oxygen functionalities were subsequently applied for covalent immobilization of human serum albumin (HSA) as a natural nanoscaffold for covalent immobilization of Thomsen-nouvelle (Tn)

Background: Colorectal cancer (CRC) is the third most common cancer globally. In Jordan, it is the number one cancer among men and the second most common cancer among women, accounting for 15% and 9.4% respectively of all male and female diagnosed cancers. This study aimed to evaluate the knowledge and perceptions about colorectal cancer risk factors, signs and symptoms in Jordan and to provide us

Whey protein powder functionality is expected to be closely linked to both structure and properties of the proteins. It is essential that whey protein powders are easily dispersed and dissolved in order to fulfil the specified nutrient content and the functionality in the final product. Poor rehydration can cause challenges on an industrial level as well as for the consumers. In this thesis, severWhey protein powder functionality is expected to be closely linked to both structure and properties of the proteins. It is essential that whey protein powders are easily dispersed and dissolved in order to fulfil the specified nutrient content and the functionality in the final product. Poor rehydration can cause challenges on an industrial level as well as for the consumers. In this thesis, sever

Populärvetenskaplig sammanfattningEn stor del av världens energikällor är baserade på förbränning och kan återfinnas i allt från bilar och båtar som drivs av förbränningsmotorer till gasturbiner och kraftverk som används till elproduktion. Den centrala biten inom förbränning är en kemisk omvandling av bränslet då det reagerar med syre till att bilda de två huvudsakliga produkterna, vatten och koldAbstractThe work presented in this thesis is mainly focused on the development andapplication of infrared laser-induced grating techniques in order to measure the gasphase temperature and species concentrations in reactive flows. The two techniquesused for this purpose are laser-induced grating spectroscopy (LIGS) and degeneratefour-wave mixing (DFWM). Their coherent nature allows to perform laser

III-V compound materials have long been used in RF applications in high-electron-mobility-transistors (HEMTs) and bipolar-junction-transistors (BJTs). Now, III-V is also being viewed as a material candidate for replacing silicon in the n-channel in CMOS processes for increased drive currents and reduced power consumption in future nodes. Another alternative to increase the drive current is to use III-V compound materials have long been used in RF applications in high-electron-mobility-transistors (HEMTs) and bipolar-junction-transistors (BJTs). Now, III-V is also being viewed as a material candidate for replacing silicon in the n-channel in CMOS processes for increased drive currents and reduced power consumption in future nodes. Another alternative to increase the drive current is to use

Accessibility plays an essential role in determining real estate prices and land use. An understanding of how accessibility and changes in accessibility influence real estate prices is key to making decisions regarding investments in infrastructure projects. From an accessibility point of view, it is not clear that there should be differences in valuation depending on the mode of public transport,

The first experimental investigation of the near-threshold cross section for incoherent π-photoproduction on the deuteron γd→π-pp is presented. The experimental technique involved detection of the ≈131 MeV γ ray resulting from the radiative capture of photoproduced π-in the target. The total cross section was measured using an unpolarized tagged-photon beam, a liquid-deuterium target, and three ve

The PHENIX experiment has studied nuclear effects in p+Al and p+Au collisions at sNN=200GeV on charged hadron production at forward rapidity (1.4