Popular Abstract in Swedish Denna avhandling behandlar modellsystem för farmaka som har DNA och RNA som mål i cellen. Framförallt behandlar den hur strukturen hos DNA och RNA påverkas av inbindning av olika substanser, samt hur fort denna inbindning sker. Tre olika typer av farmaka behandlas: 1. Platinaföreningar som länge använts som cytostatika, 2. RNA interferens som främst har utvecklats undDrugs targeting nucleic acids were studied in DNA and RNA model systems. The effects were investigated with respect to structural and thermodynamic influence, kinetics, and biological function. The drugs employed in this thesis were anticancer active platinum(II) complexes, polyamine derivatives, and siRNA. Structural changes were determined by use of chemical probing and circular dichroism (CD),

Performance modeling is an important topic in capacity planning and overload control for web servers. We present a queueing model of an Apache web server that uses bursty arrival traffic. The arrivals of HTTP requests is assumed to be a Markov Modulated Poisson Process and the service discipline of the server is processor sharing. The total number of requests that can be processed at one time is l

Product design, packaging and logistics have a significant impact on the efficiency and effectiveness of supply chains. The packaging design is usually limited by the product characteristics hence influencing possible logistical solutions. A need has been recognized to consider packaging and logistical issues early in the product development process. Case studies involving companies from the Swedi

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TiO2(B), a potential catalyst support, has been synthesized from a support precursor, K2Ti4O9. High resolution electron microscopy revealed that the 32% volume loss in this transformation is achieved by formation of facetted microvoids, around 10 nm in size, maintaining the morphology and size of the original crystals. A structural mechanism, including a hypothetical structure for a K2Ti 2O5 inter

Abstract This paper aims to gain a better understanding of the impact different micro-geometries has on stress distribution in cutting tools. Both principal and effective stress distribution are studied since these quantities have a major impact on the occurrence of damages in the cutting tool such as crack formation, flaking, chipping, breakage and plastic deformation. The development of a stagna

We report on an international collaboration, the FERRUM Project, whichaims at extending the database of experimental oscillator strengths foriron group elements and possibly evaluating theoretical andastrophysical data. The selection of individual projects is made withrespect to their relevance for abundance work and plasma diagnostics inastrophysics. In this paper we present recent measurements o

Embedded in the Western scientific rationality Hofstede’s methodological approach is constructed on a quantitative method characterized by a carefully selected sample of well educated white ‘men’ from the middle classes working for the same company and sharing similar occupation. The appointment of these men as the norm for national culture might mislead one to believe that Hofstede perceive of cu

This paper presents an analysis of the point-spread functions (PSFs),which may be expected in the so-called improved seeing limited mode forthe Euro50 (Extremely large telescope with a 50 m aperture). This modecomprises adaptive control of the deformable secondary mirror of theaplanatic Gregorian telescope configuration using guide stars in a widefield. I may result in efficient compensation of tu

Popular Abstract in Swedish Vid internationell handel med varor utgår olika skatter och avgifter; dessutom kan varorna vara föremål för import- och exportbegränsningar. Genom frihandelsavtal kan dock bestämmas att vissa varor får importeras och exporteras tullfritt. De bestämmelser som således gäller för olika varor sammanfattas för skilda varuslag i tulltaxan. Varuklassificeringen har därför storIn international commerce, various taxes and charges are levied on commodities; besides, goods may be subject to import and export restrictions. However, free-trade agreements may stipulate that some goods can be imported and exported free of charge. The regulations pertaining to different types of merchandise are reflected in the customs tariff of a state or customs union. The application of many

Abstract is not available

Max Liljefors, Art History and Visual Studies Technologization of Vision, Visualization of knowledge: The Role of “The Visual” in Conceptualizing ESS. ESS is popularly described as a gigantic microscope, which will use neutrons instead of ordinary light to let us see inside matter on the subatomic level. Other metaphors also foreground vision: “Seeing with neutron eyes”, and “Neutrons give the b