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Centrality dependence of inclusive J/psi production in p-Pb collisions at root S-NN=5.02TeV

We present a measurement of inclusive J/psi production in p-Pb collisions at root S-NN = 5.02 TeV as a function of the centrality of the collision, as estimated from the energy deposited in the Zero Degree Calorimeters. The measurement is performed with the ALICE detector down to zero transverse momentum, p(T), in the backward (-4.46 < y(cms) < -2.96) and forward (2.03 < y(cms) < 3.53) rapidity in

Rituximab and abatacept but not tocilizumab impair antibody response to pneumococcal conjugate vaccine in patients with rheumatoid arthritis

Introduction: The objective of the study was to investigate the impact of newer biologic treatments including rituximab, abatacept and tocilizumab on antibody response following pneumococcal vaccination using a 7-valent conjugate vaccine in patients with established rheumatoid arthritis (RA). Methods: Patients with RA receiving rituximab, abatacept or tocilizumab as monotherapy or combined with me

An Empirical Investigation of Efficiency and Price Uniformity in Competing Auctions

Abstract in Undetermined This paper investigates hypotheses related to efficiency and price uniformity in online competing auctions based on two theoretical predictions from Peters and Severinov [Peters, M., Severinov, S., 2006. Internet auctions with many traders. Journal of Economic Theory 130, 220–245]. The investigation is conducted using a large and ideal data set for online competing train t

Clearing Connections by Few Agents

We study the problem of clearing connections by agents placed at some vertices in a directed graph. The agents can move only along directed paths. The objective is to minimize the number of agents guaranteeing that any pair of vertices can be connected by a underlying undirected path that can be cleared by the agents. We provide several results on the hardness, approximability and parameterized co

Effect of storage time and temperature on stability of bioactive compounds in aseptically packed beverages prepared from rose hips and sea buckthorn berries

Rose hips and sea buckthorn berries contain high amounts of beneficial bioactive compounds. In this study the content and stability of natural vitamins and antioxidants were investigated in two fruit beverages made from rose hip powder, sea buckthorn berry puree and white grape juice concentrate, and wheat germ oil in one of the beverages. Beverages were formulated, pasteurised and filled aseptica

Experimental Evaluation of the Response of Coastal Mediterranean Planktonic and Benthic Metabolism to Warming

The Mediterranean Sea has been identified as one of the hotspots for climate change. Intense warming in the Mediterranean Sea may have strong implications for biological activity and ecosystem functioning. To elucidate the effects of warming on planktonic and benthic metabolism, we performed experiments under different increasing temperature regimes, ranging from three to six different temperature

Nutritional Status of Patients with Cutaneous Leishmaniasis from a Tropical Area of Bolivia, and Implications for Zinc Bioavailability

Macro and micronutrient deficiencies are a significant problem among people in rural areas in developing countries. Deficiencies may lead to an impaired immune system making the organism vulnerable to infections and diseases. In this paper, the dietary intake, anthropometric measurements, zinc and copper levels in serum, of patients with cutaneous leishmaniasis (CL) are compared with a group of he

Dryland vegetation response to wet episode, not inherent shift in sensitivity to rainfall, behind Australia's role in 2011 global carbon sink anomaly

There is compelling new evidence that semi-arid ecosystems are playing a pivotal role in the inter-annual variability and greening trend of the global carbon cycle (Ahlström et al., 2015). The situation is exemplified by the vast inland region of Australia, the driest inhabited continent. Using a global model, Poulter et al. (2014) inferred that Australian ecosystems contributed 57% of a record gl

Platelet activation by Streptococcus pyogenes leads to entrapment in platelet aggregates from which bacteria subsequently escape.

Platelet activation and aggregation has been reported to occur in response to a number of Gram-positive pathogens. Here we show that platelet aggregates induced by Streptococcus pyogenes were unstable and viable bacteria escaped from the aggregates over time. This was not due to a differential activation in response to the bacteria as compared with physiological activators. All the bacteria isolat

High methane yields and stable operation during anaerobic digestion of nutrient-supplemented energy crop mixtures

The feasibility of digesting energy crops supplemented with macro- and micronutrients instead of manure, without the commonly applied long hydraulic retention time (HRT), was investigated in long-term, single-stage continuous stirred tank processes. The crops used were mixtures of sugar beets, maize and whole crop triticale. The organic loading rate (OLR) measured as a total solid (TS) was 1.5-5.5

HIF-1α can act as a tumor suppressor gene in murine Acute Myeloid Leukemia.

Self-renewal of hematopoietic stem cells (HSCs) and leukemia-initiating cells (LICs) has been proposed to be influenced by low oxygen tension (hypoxia). This signaling, related to the cellular localization inside the bone marrow niche and/or influenced by extrinsic factors, promotes the stabilization of hypoxia inducible factors (HIFs). Whether HIF-1α can be used as a therapeutic target in the tre

C-Reactive Protein, Fibrinogen, and Cardiovascular Disease Prediction

Background There is debate about the value of assessing levels of C-reactive protein (CRP) and other biomarkers of inflammation for the prediction of first cardiovascular events. Methods We analyzed data from 52 prospective studies that included 246,669 participants without a history of cardiovascular disease to investigate the value of adding CRP or fibrinogen levels to conventional risk factors

Grb10 is a dual regulator of receptor tyrosine kinase signaling

The adaptor protein Grb10 is a close homolog of Grb7 and Grb14. These proteins are characterized by an N-terminal proline-rich region, a Ras–GTPase binding domain, a PH domain, an SH2 domain and a BPS domain in between the PH and SH2 domains. Human Grb10 gene encodes three splice variants. These variants show differences in functionality. Grb10 associates with multiple proteins including tyrosine

IFNγ in combination with IL-7 enhances immunotherapy in two rat glioma models.

Peripheral immunization, using a combination of interferon-gamma (IFNγ)- and interleukin-7 (IL-7)-producing tumor cells, eradicated 75% of pre-established intracerebral N32 rat glioma tumors, and prolonged survival in the more aggressive RG2 model. Rats immunized with IFNγ- and IL7-transduced N32 cells displayed increases in IFNγ plasma levels and proliferating circulating T cells when compared wi

Biohydrogen production from wheat straw hydrolysate using Caldicellulosiruptor saccharolyticus followed by biogas production in a two-step uncoupled process

A two-step, un-coupled process producing hydrogen (H2) from wheat straw using Caldicellulosiruptor saccharolyticus in a ‘Continuously stirred tank reactor’ (CSTR) followed by anaerobic digestion of its effluent to produce methane (CH4) was investigated. C. saccharolyticus was able to convert wheat straw hydrolysate to hydrogen at maximum production rate of approximately 5.2 L H2/L/Day. The organic

Target temperature management after out-of-hospital cardiac arrest-a randomized, parallel-group, assessor-blinded clinical trial-rationale and design

Background Experimental animal studies and previous randomized trials suggest an improvement in mortality and neurologic function with induced hypothermia after cardiac arrest. International guidelines advocate the use of a target temperature management of 32 degrees C to 34 degrees C for 12 to 24 hours after resuscitation from out-of-hospital cardiac arrest. A systematic review indicates that the