A new DNA variant in the promoter region of the human cystatin C gene has been detected by direct sequencing. The base substitution generates a newDdeO restriction site, thus allowing the design of a rapid polymerase chain reaction assay for analysis of this polymorphism in the population.

The intangible nature of software means that traditional processes for managing product development are not sufficiently effective. This, in combination with the increasing share of software in technical products, has had the effect of making it difficult to identify improvement proposals for engineering processes in many cases. This thesis uses both qualitative and quantitative research methods t

The initial oxidation of Rh(100) has been studied using high resolution core level spectroscopy, low energy electron diffraction, surface x-ray diffraction, scanning tunneling microscopy, and density functional theory. We report a structural study of an oxygen induced structure displaying a c(8x2) periodicity at an oxygen pressure above 10(-5) mbar and using a sample temperature of 700 K. Our expe

Linkage disequilibrium (LD), the nonrandom occurrence of alleles in haplotypes, has long been of interest to population geneticists. Recently, the rapidly increasing availability of genomic polymorphism data has fueled interest in LD as a tool for fine-scale mapping, in particular for human disease loci(1). The chromosomal extent of LD is crucial in this context, because it determines how dense a

Surgical procedures in hemophiliacs is a demanding challenge for the surgeon and hematologist. This report deals with a successful laparoscopic cholecystectomy in a young patient with hemophilia B. Despite a prolonged operation time, because of a partially intrahepatic gallbladder, no bleeding complications were registered and the patient recovered well. Laparoscopic cholecystectomy seems to be th

Aim To describe the relative impact on survival of the delay from estimated time of collapse to call for an ambulance among patients who suffer from a bystander witnessed out of hospital cardiac arrest of a cardiac aetiology. Methods A majority of all ambulance organizations in Sweden (covering 85% of Sweden inhabitants) participate in a National survey of out of hospital cardiac arrest. Results I

Popular Abstract in Swedish Helicobacter pylori är en av de vanligaste infektionerna hos människan. H. pylori framodlades för första gången 1983 av Robin Warren och Barry Marshall. Bakterien ger en kronisk inflammation i magslemhinnan. H. pylori orsakar magsår och möjligheten att behandla sjukdomen med antibiotika har inneburit en revolution inom sjukvården. Hos flertalet sker infektionen i barndoHelicobacter pylori is one of the most common infections in man. The infection is often acquired during childhood and usually results in a chronic life-long inflammation in the gastric mucosa. The aim of our studies was to investigate the association between H. pylori seropositivity and the development of gastric and oesophageal carcinomas. Nested case-control studies were performed in the Malmö P

It is generally difficult to analytically derive models describing the echo attenuation in pulsed gradient spin-echo (PGSE) experiments for even he simplest porous systems that are commonly studied-especially when the gradient pulse (delta) is of finite length compared to the timescale of the diffusion measurement (Delta). Consequently, various levels of approximation are used to evaluate PGSE ex

Popular Abstract in Swedish Målet med kollektivtrafik är bl a att anordna transportförsörjning för alla samhällsgrupper på ett samhällsekonomiskt effektivt vis. En grupp medborgare är rullstolsburna resenärer, vars speciella förutsättningar ställer särskilda krav på transportsystemets utformning. För att utröna dessa speciella förutsättningar på ett ansvarsfullt sätt, är det viktigt att man anläggEliciting wheelchair-seated passengers’ perspective of safety and comfort is both useful and mandatory, particularly for researchers, clinicians, transit authorities, and for operators during purchase and use of vehicle technologies in existing and planned future transport systems. Therefore, the overarching objective of this thesis was to delineate the question of safety and comfort as perceived

Rapporten bygger på en undersökning där fyra dagstidningars bild av alkohol under tre tidsperioder ingår. resultatn visar att pressmaterialet inte uppvisar några större variationer vare sig mellan de stuerade tidningarna eller över tid. vidare visas att alkholfrågan beskrivs ur en rad olika perspektiv, dock sällan ur ett hälsoperspektiv.

We present a flexible and compact, digital, lock-in detection system and its use in high-resolution tunable diode laser spectroscopy. The system involves coherent sampling, and is based on the synchronization of two data acquisition cards running on a single standard computer. A software-controlled arbitrary waveform generator is used for laser modulation, and a four-channel analog/digital board r

Endocannabinoids exert an important neuromodulatory role via presynaptic cannabinoid CB1 receptors and may also participate in the control of neural cell death and survival. The function of the endocannabinoid system has been extensively studied in differentiated neurons, but its potential role in neural progenitor cells remains to be elucidated. Here we show that the CB1 receptor and the endocann

High plasma levels of VLDL are associated with increased risk for atherosclerosis. Here we show that VLDL (75 to 150 microg/mL) activates nuclear factor-kappaB (NF-kappaB), a transcription factor known to play a key role in regulation of inflammation. Oxidation of VLDL reduced its capacity to activate NF-kappaB in vitro, whereas free fatty acids such as linoleic and oleic acid activated NF-kappaB