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Apolipoprotein E4 (ApoE4), the major genetic risk factor for Alzheimer's disease (AD), is vital for understanding cellular processes involved in AD pathogenesis. Evidence implicates endosomes as a central player in AD, where endosomal enlargement in neurons is among the earliest changes in AD. This enlargement was reported to be enhanced in APOE4 carriers. Cells internalize ApoE into endosomes for

MicroRNAs (miRNAs) are pivotal post-transcriptional regulators that orchestrate gene expression programs governing cancer initiation, progression, metastasis, and therapeutic resistance. Among their many targets, the WNT signaling pathway, a key driver of malignancy, is tightly controlled by miRNAs, forming intricate feedback loops that shape tumor behavior. Concurrently, flavonoids, naturally occ

Staphylococcus aureus remains one of the most elusive targets in bacterial vaccinology, primarily due to its complex immune evasion strategies and the phenomenon of immune imprinting. Despite decades of research and numerous clinical trials, no vaccine has demonstrated protective efficacy in humans. This review examines the underlying reasons for these failures and proposes a rational, integrativ

Gastrointestinal (GI) cancers, including esophageal, gastric, pancreatic, liver, and colorectal malignancies, represent a major global health burden due to their high incidence, aggressive nature, and limited treatment outcomes. This review explores the therapeutic potential of carvacrol, a naturally occurring monoterpenoid phenol predominantly found in oregano and other aromatic plants. Carvacrol

Industrial CO2 emissions, particularly from flue gases, are a major barrier to climate change mitigation. Carbon capture, particularly with bioenergy (BECCS), offers a pathway to negative emissions. This study models an MEA-based carbon capture system using operational data from a stand-alone pulp mill, focusing on its energy impact and optimization strategies. The analysis distinguishes between h

Additives such as binders and hydrophobic agents are commonly introduced into the fibrous Gas Diffusion Layer (GDL) of proton exchange membrane fuel cells to enhance mechanical strength and facilitate water management. However, the effect of additive/fiber content and surface wettability on water removal, oxygen diffusion, and heat conduction remains insufficiently understood. In this work, we dev

Type 1 diabetes, formerly known as juvenile diabetes or insulin-dependent diabetes, results from the specific autoimmune destruction of the pancreatic islet beta cells. The subsequent loss of insulin leads to increased blood and urine glucose. The classical symptoms are polyuria (frequent urination), polydipsia (increased thirst), polyphagia (increased hunger), and weight loss. The disease may be

Helsingborg has a strong trading heritage and a unique strategic location within the Nordic region. It's no coincidence that these factors have combined in the digital age to position Helsingborg as a key player in the world of e-commerce.The city's natural geographic advantages, alongside significant investments in infrastructure, have established a strong foundation for Helsingborg to become a l

Despite the multidimensionality of knowledge and technology transfer (KTT), existing quantitative evaluations predominantly focus on a limited range of channels, often resulting from the availability of data rather than theoretical considerations. To address this gap, we leverage unstructured data from university websites to develop indicators that provide a comprehensive view of universities’ KTT

The South African forestry supply chain is a complex system that involves both the production of trees (site preparation, re-establishment, tending, and maintenance operations) and the production and distribution of wood products from plantation stands to the pulp- and sawmills. This paper reports on a study that investigated the suitability of discrete-event simulation for modelling forestry supp

Dyes are routinely used in the textile and pharmaceutical industries, causing serious environmental issues by decreasing water quality. Photocatalysts are used for dye degradation, and different acting mechanisms may occur during the photodegradation process. In this study, Ni nanoparticles were heated to selected temperatures up to 500 °C under an ambient atmosphere and subsequently supported on

During the last decade the intersection between social welfare research and the ecological crisishas been gaining increasing interest through discussions about sustainable welfare and eco-social policies. Less attention has been paid, however, to eco-social risks and to how climatechange “will impact the nature and distribution of social risks across di!erent parts of thepopulation” (Hirvilammi et

Presentationen rör barn och ungas vardagliga geografier samt det sociala arbetets etablerade förhållningssätt till desamma. Särskilt fokus kommer riktas mot hur erfarenhetsnära tolkningar av barn och ungas egna berättelser om ”den vanliga vardagen” kan utvidga det sociala arbetets förståelse för barn och ungas geografier, och hur dessa tolkningar kan berika såväl forskning som praktik i socialt ar

Nowadays, Pt-CeO2 interfaces are very popular in many applications. In particular, this system is widely used in catalysis for the reverse water gas-shift (RWGS) reaction aiming to stop the dangerous advancement of the global warming effect. Nevertheless, some complex atomic events occurring at this interface are still unclear. In this work, superhydrophobic Pt-CeO2 nanoparticles were used in the

Freshwater ecosystems in boreal and temperate regions are undergoing rapid change as increasinginputs of terrestrially derived dissolved organic matter (DOM) and nutrient enrichment alter ecosystemfunctioning. These processes, known as brownification and eutrophication, vary across space and timebut can profoundly reshape carbon cycling, microbial activity, and water quality. This thesis investiga

A classic in the field of Medical Humanities, the late Philip Sandblom's study of art and ill health first appeared in English in 1982. This is a new, extended version, based on the definitive Swedish edition of 2022.In riveting analyses of the interplay between illness and art, music, and literature, Creativity and illness shows how various diseases and disabilities have affected the works of famA pioneering work in the field of Medical Humanities, first published as Creativity and disease in 1982, Creativity and illness now appears in a fresh, extended version based on the definitive Swedish edition published in 2022. A renowned surgeon, Philip Sandblom was also a connoisseur of the fine arts, and throughout his life he was fascinated by the interplay between art and health. Having start

Adaptive control is often used for friction compensation in trajectory tracking tasks because it does not require torque sensors. However, it has some drawbacks: first, the most common certainty-equivalence adaptive control design is based on linearized parameterization of the friction model, therefore nonlinear effects, including the stiction and Stribeck effect, are usually omitted. Second, the