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Heredity is estimated to cause at least 20% of colorectal cancer. The hereditary nonpolyposis colorectal cancer subset is divided into Lynch syndrome and familial colorectal cancer type X (FCCTX) based on presence of mismatch repair (MMR) gene defects.
A balance between different experiences of occupations in everyday life is important for well-being. The study aim was to describe hassles and uplifts in everyday occupations among women on long-term sick-leave due to stress-related disorders. The sample consisted of 77 women and experiences were collected by the THU-5 instrument. The statements were analysed using quantitative content analysis. D
Background: Altered androgen hormone homeostasis and androgen receptor (AR) activity have been implicated in ovarian carcinogenesis but the relationship between AR expression in ovarian cancer and clinical outcome remains unclear. Methods: In this study, the prognostic impact of AR expression was investigated using immunohistochemistry in tissue microarrays from 154 incident cases of epithelial ov
Histamine-containing enterochromaffin-like (ECL) cells are numerous in the gastric mucosa. They operate under the. control of gastrin. ECL-cell tumors (gastric carcinoids) may arise as a consequence of sustained hypergastrinemia. For reasons unknown, such tumors have a female preponderance both in laboratory animals and humans. The present study consisted of four experiments exploring the possibil
The Lepidoptera fauna of the Danish island of Anholt is surveyed, and 1160 species are recorded. Anholt is situated in Kattegat 44 km from Denmark and 47 km from Sweden. The history and environment of the island are briefly discussed, with special focus on the flora, and earlier studies of the Lepidopterera fauna of Anholt are dealt with. The present study is in first hand based on material collec
Abstract in UndeterminedThe Land-Use, Land-Use Change and Forestry (LULUCF) sector of the Kyoto Protocol requires New Zealand to monitor changes in the country’s carbon stocks, including those within indigenous forests. Podocarpus cunninghamii Colenso was, in pre-human times, a dominant tree species within the forests of the South Island high country. Anthropogenic disturbance, primarily fire, has
Although high-throughput studies of gene expression have generated large amounts of data, most of which is freely available in public archives, the use of this valuable resource is limited by computational complications and non-homogenous annotation. To address these issues, we have performed a complete re-annotation of public microarray data from human skeletal muscle biopsies and constructed a m
Anterior cruciate ligament (ACL) injuries are common, severe knee injuries that result in a high risk of developing knee osteoarthritis (OA) in the affected individuals. As proof of high impact forces applied to cartilage and bone at the time of injury, traumatic bone marrow lesions and osteochondral fractures, located predominantly in the lateral tibiofemoral compartment, are commonly associated
Calculated triplet excited state potential energy surfaces are presented for a set of three bis-tridentate Ru(II)-polypyridyl dies covering a wide range of room temperature excited state lifetimes: [Ru(II)(tpy)(2)](2+), 250 ps; [Ru(II)(bmp)(2)](2+), 15 ns; and [Ru(II)(dqp)(2)](2+), 3 mu s (tpy is 2,2':6',2 ''-terpyridine, bmp is 6-(2-picoly1)-2,2'-bipyridine, and dqp is 2,6-di(quinolin-8-yl)Fridin
A review of the scientific development and progress in lichenology is reflected in 50 brief biographies of E. Acharius, V. Ahmadjian, T. Ahti, A. Aptroot, Y. Asahina, I. M. Brodo, D. H. Brown, B. Büdel, A. Crespo, W. L. Culberson, J. A. Elix, D. Fahselt, B. Fink, T. Friedl, D. J. Galloway, M. Galun, J. Hafellner, M. E. Hale, D. L. Hawksworth, A. Henssen, R. Honegger, P. W. James, P. M. Jørgensen,
The very young Wabar craters formed by impact of an iron meteorite and are known to the scientific community since 1933. We describe field observations made during a visit to the Wabar impact site, provide analytical data on the material collected, and combine these data with poorly known information discovered during the recovery of the largest meteorites. During our visit in March 2008, only two
Popular Abstract in Swedish Kroppens immunförsvar består av röda och vita blodceller som alla härstammar från blodbildande stamceller i benmärgen. Stamcellerna har den unika egenskapen att kunna producera alla typer av blodceller och upprätthålla produktionen hela livet ut. I princip all blodbildning (hematopoes) sker i benmärgen, förutom för T celler. Dessa är vita blodceller som produceras i thyhe hematopoietic development is a highly dynamic but tightly regulated process. The flexibility to produce blood cells through more than one route will allow the blood system to respond rapidly in stress situations such as infections. On the other hand, regulation of the blood system is required to prevent blood cells from uncontrolled proliferation that could result in leukemia or bone marrow fai
To investigate the genotype and phenotype in families with adenosine triphosphate-binding cassette, sub-family A, member 4 (ABCA4)-associated retinal degeneration.
Developing new and useful methods in asymmetric catalysis is of continuous importance. A current challenge is to address the imperatives of green chemistry, such that processes maximize resource-efficiency and minimize the generation of waste. To this end, this article discloses the potential of alpha-amino acids in the development of entropy-controlled and enantiodivergent Lewis acid catalysis. I
Cigarette smoke exposure increases the risk of stroke. However, the underlying molecular mechanisms are poorly understood. Endothelin system plays key roles in the pathogenesis of stroke. The present study was designed to examine if lipid-soluble (dimethyl sulfoxide-soluble) cigarette smoke particles (DSP) induces upregulation of contractile endothelin type B (ETB) receptors in rat cerebral arteri
We have studied the (110) GaAs surface of a structure containing ortho twins by cross-sectional scanning tunnelling microscopy and we have compared the experimental results with ab initio density functional theory calculations and STM simulations. Both experimentally and theoretically we find that the surface of different twin crystallites are significantly displaced with respect to each other, pa
