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An isochromosome of the long arm of chromosome 17, i(17q), is the most frequent genetic abnormality observed during the disease progression of Philadelphia chromosome-positive chronic myeloid leukemia (CML), and has been described as the sole anomaly in various other hematologic malignancies. The i(17q) hence plays a presumably important pathogenetic role both in leukemia development and progressi

Solutions of n-nonyl-beta-D-glucoside (C(9)G(1)), n-decyl-beta-D-glucoside (C(10)G(1)), n-dodecyl-beta-D-maltoside (C(12)G(2)) n-tetradecyl-beta-D-maltoside (C(14)G(2)) and C(9)G(1)/C(10)G(1) mixtures have been characterised by capillary viscometry and rheology in H2O and D2O, in order to map the influence of surfactant characteristics on micellisation over a wide concentration range. For the malt

Physical activity is regarded as an important component of a healthy lifestyle. Several social and environmental factors have systematically emerged as barriers to low leisure time physical activity (LTPA), for example, lack of money, low social support due to lack of supportive family or friends, and living in high crime rate areas. Low LTPA has been found to be strongly associated with low socio

Aims: To determine the number of patients needed to be screened (NNS) and allocated (NNA) in order to include one participant in a randomized clinical trial (RCT), and to compare the characteristics of patients accepting or declining participation in the RCT. Methods: The recruitment process of an ongoing multicenter RCT, comparing surgical and non-surgical interventions after acute anterior cruci

Excited states have been studied in Ar-35 following the O-16(Mg-24,1alpha1n)Ar-35 fusion-evaporation reaction at 60 MeV using the Ge-detector array GASP. A comparison with the mirror nucleus Cl-35 shows two remarkable features: (i) A surprisingly large energy difference for the 13/2(-) states, in which the hitherto overlooked electromagnetic spin-orbit term is shown to play a major role, and (ii)

Cat's Claw (Uncaria tomentosa) water extracts, essentially free of oxindole alkaloids, have been shown to possess a broad spectrum of biological activity including DNA repair enhancement and antiinflammatory properties. These two biological mechanisms are key molecular targets to develop treatments that protect skin exposed to ultraviolet light from the sun. Because C-Med-100, a Cat's Claw water e

Overall migration speed is likely to be a trait under selection pressure in animals migrating annually between habitats for reproduction and survival. A general expression was used for migration speed (V-migr), accounting for energy accumulation and transport, and derive how V-migr scales with body mass for three types of migratory locomotion: running, swimming and flying (powered and soaring flig

OBJECTIVES: The sensitizing properties of organic acid anhydrides (OAA) were evaluated in a rat model. METHODS: The development of specific immunoglobulin (Ig)E and Ig G in serum was investigated after immunization with 14 OAA and 3 OAA conjugates. Brown Norway rats were injected intradermally with 0.1 ml of 0.2 M OAA in liquid paraffin or 1.4 mg of rat serum albumin conjugate in saline. Serum sam

There have been contradictory reports on the shift in the T-cell cytokine expression pattern of peripheral blood mononuclear cells from patients with atopic dermatitis (AD); more specifically the interleukin (IL)-4 and interferon (IFN)-gamma profiles. The aim of this study was to shed further light on this contradiction by measuring the intracellular cytokines IL-4 and IFN-gamma by flow cytometry

The common approach for constructing factor mimicking portfolios is to go long in assets with high loadings and to short-sell those with low loadings on some background factors. As a result portfolios containing stocks with low loading on the background factor receive negative betas against the corresponding mimicking portfolio. Thus, such portfolios appear as hedges against the background risk an

Evidence for a novel route of adult hematopoietic stem cell lineage commitment through Lin(-)Sca-1(+)Kit(+)Flt3(hi) (LSKFlt3(hi)) lymphoid-primed multipotent progenitors (LMPPs) with granulocyte/monocyte (GM) and lymphoid but little or no megakaryocyte/erythroid (MkE) potential was recently challenged, as LSKFlt3(hi) cells were reported to possess MkE potential. Herein residual (1-2%) MkE potentia

Objective: To analyze sex differences among adult, never-treated patients referred for central stimulant treatment of ADHD. Method: Data for 600 consecutive patients from northern Norway referred for evaluation by an expert team during 7 years were analyzed. General background information, diagnostic and social history, and symptom profiles were compared between previously never-treated men and wo

This thesis describes six empirical investigations of two techniques applied to software inspections, namely reading techniques and fault content estimation techniques. The first part of the thesis presents a series of experiments of a novel reading technique called usage-based reading. The second part investigates fault content estimation applied to the software inspection process. The estimation

Association studies were carried out in a sample of 86 patients from Sweden who had survived a myocardial infarction (MI) at a young age and 93 age-matched healthy individuals, to compare the impact of polymorphisms at the apolipoprotein (apo) AI-CIII-AIV gene cluster on among-individual differences in plasma lipid and lipoprotein traits, the five high density lipoprotein (HDL) subclasses (2b to 3

We previously showed concordance between Goodpasture syndrome antibody binding and production of experimental glomerulonephritis using human chimeric proteins. We now examine a more limited aminoterminal region of alpha(3)( IV) non- collagenous domain ( NC1) and the impact of single amino acid ( AA) mutations of this region on glomerulonephritis induction. Rats were immunized with collagenase- sol

Agricultural overproduction has led the European Union to encourage long-term abandonment of agricultural land and the adoption of management practices which enhance transition to semi-natural grassland or forest. This paper reports the results of a field study conducted in newly abandoned agricultural land where the development of the mycorrhizal community was investigated in response to manipula

Efficient xylose utilisation by microorganisms is of importance to the lignocellulose fermentation industry. The aim of this work was to develop constitutive catabolite repression mutants in a xylose-utilising recombinant Saccharomyces cerevisiae strain and evaluate the differences in xylose consumption under fermentation conditions. S. cerevisiae YUSM was constitutively catabolite repressed throu