Mycobacteriophage endolysins have emerged as a potential alternative to the current antimycobacterial agents. This study focuses on mycolylarabinogalactan hydrolase (LysB) enzymes of the α/β-hydrolase family, which disrupt the unique mycolic acid layer of mycobacterium cell wall. Multiple sequence alignment and structural analysis studies showed LysB-D29, the only enzyme with a solved three-dimens

Multiple Correspondence Analysis (MCA) has been applied to animal bones from the Late Iron Age (650–1050 CE) at the site of Old Uppsala, Sweden, to explore meat consumption and waste management at the site and to evaluate the inferential value of MCA, as indicated by earlier research using this technique. MCA describes variation within the data, which provides a platform from which to contextualiz

Orthostatic hypotension (OH) is associated with increased risk of trauma and cardiovascular events. Recent studies have identified new genetic variants that influence orthostatic blood pressure (BP). The aim of this study was to investigate the associations of candidate gene loci with orthostatic BP responses in older adults. A total of 3,430 participants aged ≥50 years from The Irish Longitudinal

Riksbanken bör anpassa sin penningpolitik efter det nya läget i ekonomin, skriver nationalekonomerna Fredrik N G Andersson och Lars Jonung i en slutreplik.

Usages of the Past in Roman Historiography contains 11 articles on how the Ancient Roman historians used, and manipulated, the past. What did they seek to accomplish by participating in its re-creation, what tools did they have at their disposal to do so, and which underlying conceptualisations of history can we glimpse behind their efforts? Key themes include the impact of the transformation from

Culture and discourses affect our understanding of the archive in the digital environment: preconceptions, norms, and practices developed in a paper-based administration colour and limit perceptions of digital archives. It can be difficult to reimagine the archive in the context of e-government and the networked environment, where the complexity of archival issues increases. This is a global probl

Media firms sometimes allow consumers to pay to remove advertisements from an ad-based product. We formally examine an ad-based monopolist's incentives to introduce this option. When deciding whether or not to introduce the option to pay, the monopolist compares the potential direct revenues from consumers who pay, with the lost advertising revenues resulting from the subsequent ad removal. If the

BACKGROUND: Pain is a common problem for individuals with cerebral palsy (CP). In Sweden, 95% of children and adolescents with CP are followed in a national follow-up programme (CPUP), which includes data on pain. The purpose of this study was to investigate the prevalence of pain based on age, sex, gross motor function and source of report (self or proxy). Pain intensity, pain site, and how much

Many countries strive for continued reductions in energy demand from new buildings as a way of mitigating the impact of climate change. Consequently, the importance of accurate and efficient building performance simulations (BPS) increases to improve the prediction in energy demand during the design-process for buildings. As observed in earlier studies, there is currently a performance gap between

An online, multimedia edition of 'A Description of the Valley of Chamouni, in Savoy' (1819), by Samuel Glover. This edition brings to light a forgotten and important work of travel literature about Chamonix-Mont Blanc, and documents its close connections with the activities of Mary and Percy Shelley during to the so-called 'Frankenstein Summer' of 1816, and with high-profile exhibitions about Cham

Objective: Long interspersed nuclear element 1 (LINE-1) encodes 2 proteins, the RNA binding protein p40 and endonuclease and reverse transcriptase (open-reading frame 2p [ORF2p]), which are both required for LINE-1 to retrotranspose. In cells expressing LINE-1, these proteins assemble with LINE-1 RNA and additional RNA binding proteins, some of which are well-known autoantigens in patients with sy

The independent effects of different brain pathologies on age-dependent cognitive decline are unclear. We examined this in 300 cognitively unimpaired elderly individuals from the BioFINDER study. Using cognition as outcome we studied the effects of cerebrospinal fluid biomarkers for amyloid-β (Aβ42/40), neuroinflammation (YKL-40), and neurodegeneration and tau pathology (T-tau and P-tau) as well a