Four directional and positional variants of sulfonamide-derivatized galactopyranosides were synthesized and evaluated against human galectin-1, -3, -4C (C-terminal), -7, -8N (N-terminal), -8C (C-terminal), -9N (N-terminal), and -9C (C-terminal), which revealed that one of the sulfonamide positions and directionalities (methyl 3-{4-[2-(phenylsulfonylamino)-phenyl]-triazolyl}-3-deoxy-α-D-galactopyra

Recently, the paper ”When Choices Are Mistakes” by Nielsen, Kirby, and John Rehbeck (2022) introduced a novel method to test axiomatic theories of choice under risk. This innovative approach opened new avenues for exploring decision- making processes. Ambiguity aversion, a distinct concept where probabilities of outcomes are unknown, is fundamental in understanding economic and financial decisions

In the rapidly evolving telecommunications industry, customer retention is crucial for maintaining profitability. This report investigates the performance of various machine learning models in predicting customer churn rates, which are integral to calculating Customer Lifetime Value (CLV). The focus is on a comparative analysis of several models including logistic regression, ridge regression, las

Pseudomonas are a common cause of hospital-acquired infections that may be lethal. ADP-ribosyltransferase activities of Pseudomonas exotoxin-S and -T depend on 14-3-3 proteins inside the host cell. By binding in the 14-3-3 phosphopeptide binding groove, an amphipathic C-terminal helix of ExoS and ExoT has been thought to be crucial for their activation. However, crystal structures of the 14-3-3β:E

We develop a multiscale coarse-grain model of the NIST Monoclonal Antibody Reference Material 8671 (NISTmAb) to enable systematic computational investigations of high-concentration physical instabilities such as phase separation, clustering, and aggregation. Our multiscale coarse-graining strategy captures atomic-resolution interactions with a computational approach that is orders of magnitude mor

This article considers students’ and teachers’ perceptions of shared reading (SR) in promoting reading engagement. It provides a thematic analysis of focus groups with students and teachers at a Swedish upper-secondary school who participated in an intervention consisting of SR sessions. The findings are triangulated with a student pre-intervention questionnaire that included reading habits.The st

Volcanic eruptions are documented throughout geological history and are frequently observed and experienced in the modernworld. Strong eruptions in recent decades have resulted in air and water pollution, acid snowfall, disruption in aerial transport and variousillnesses in humans and livestock. Despite their consequences, these recent events are incomparable to eruptions of a much largermagnitude

BACKGROUND: Despite oral anticoagulation, patients with atrial fibrillation (AF) remain at risk of ischemic stroke and systemic embolism (SE) events. For patients whose residual risk is sufficiently high, additional therapies might be useful to mitigate stroke risk. METHODS AND RESULTS: Individual patient data from 5 landmark trials testing oral anticoagulation in AF were pooled in A Collaboration

Energy conservation measures (ECMs) are often chosen for their immediate benefits, such as suitability to past/current climate conditions and rapid economic returns. However, the longevity of these ECMs poses a risk of becoming outdated or ineffective as climate change alters the very climatic parameters they were designed for. This paper provides insight into the foresight required when selecting

We present high spectral resolution observations of the hot Jupiter WASP-94 A b using the HARPS instrument on ESO’s 3.6-m telescope in La Silla, Chile. We probed for Na absorption in its atmosphere as well as constrained the previously reported misaligned retrograde orbit using the Rossiter–McLaughlin effect. Additionally, we undertook a combined atmospheric retrieval analysis with previously publ

Part of the chor.com 2024, The International Congress of the Choir World. Organized by the German Choral Association.Concert Choir from Hanover University of Music, Drama, and MediaConductor: Prof. Andreas Felber

Introduction: Grey pea is a largely overlooked legume in the Nordic countries, and its potential uses in various food products remain unexplored. It is a nutrient-rich crop with low environmental impact, making it an attractive option for sustainable and nutritious plant-based alternatives. Objectives: To investigate the impact of dehulling, germination, and fermentation on the bioactive (poly

Atmospheric new particle formation (NPF) is a naturally occurring phenomenon, during which high concentrations of sub-10 nm particles are created through gas to particle conversion. The NPF is observed in multiple environments around the world. Although it has observable influence onto annual total and ultrafine particle number concentrations (PNC and UFP, respectively), only limited epidemiologic

Railway incidents undermine both punctuality and capacity. As traffic volumes increase, the frequency of these incidents is also expected to increase, driven by higher asset utilization, reduced time for maintenance, and further worsened by climate change. This highlights the importance of efficient incident management and corrective maintenance. This study uses a combination of exploratory data a

The ACMG/AMP guidelines include five categories of which variants of uncertain significance (VUSs) have received increasing attention. Recently, Fowler and Rehm claimed that all or most VUSs could be reclassified as pathogenic or benign within few years. To test this claim, we collected validated benign, pathogenic, VUS and conflicting variants from ClinVar and LOVD and investigated differences at