We have evaluated if any differences in tumor radiosensitization exist between the two adenosine diphosphate ribosyl transferase (ADPRT) inhibitors nicotinamide and benzamide at fractionated low doses. A significant radiosensitizing effect with nicotinamide at a 10 mg/kg per day dose was found in the tumor model used. We found, however, no radiosensitizing effect with benzamide given according to

OBJECTIVE: To investigate the efficacy and safety of oral desmopressin in the treatment of nocturia in men. PATIENTS AND METHODS: Men aged >/=18 years with verified nocturia (>or=two voids/night) and nocturnal urine production greater than their maximum functional bladder capacity were recruited. A 3-week dose-titration phase established the optimum desmopressin dose (0.1, 0.2 or 0.4 mg). After a

The renin-angiotensin system (RAS) is developmentally up-regulated and it is essential for kidney development in several species. Given the fact that the rat lung undergoes postnatal development, the mammalian lung possesses the highest angiotensin-converting enzyme (ACE) levels and ACE activity increases during the first weeks postpartum, we tested the hypothesis that ACE inhibition influences po

In a subarachnoid hemorrhage model in the baboon, achieved through three cisternal blood injections with 1-day intervals, the cerebral arteries were dissected out 7 days after the first blood injection for electron microscopy All the animals showed ultrastructural changes in the cerebral arteries: two with severe, one with moderate, and three with mild alterations in the vessel walls. The most con

Cutting tool premature failure, caused by tool fracture and chipping, is a frequent problem in the metal cutting area. For a certain type of cutting tool, correctly identifying its load profile and property profile is very crucial for prediction of the tool premature failure. The most direct way to evaluate the load profile and property profile of a cutting tool is to identify the stress working o

We show that collisions with stellar-mass black holes can partially explain the absence of bright giant stars in the Galactic Centre, first noted by Genzel et al. We show that the missing objects are low-mass giants and asymptotic giant branch stars in the range 1-3 M-circle dot. Using detailed stellar evolution calculations, we find that to prevent these objects from evolving to become visible in

We present a new density functional theory of ideal polymer fluids, assuming nearest-neighbor bonding constraints. The free energy functional is expressed in terms of end site densities of chain segments and thus has a simpler mathematical structure than previously used expressions using multipoint distributions. This work is based on a formalism proposed by Tripathi and Chapman [Phys. Rev. Lett.

A dominant notion that homosexuality and heterosexuality give meaning to bisexuality already exists. But no one has explored the meaning that bisexuality might accrue with regard to monosexuality. Because bisexuals were never fully recognized within queer theory, the homosexual-heterosexual binary opposition continues to be the primary understanding of difference. Further, within queer theory, the

A myoelectric control system for prostheses was developed and evaluated on six healthy subjects. These were able to control a computer-animated hand in real-time with a 20 Hz update rate. A data glove, equipped with joint angle sensors, was used to train the system and to evaluate the continuous predictions of joint angles. A linear envelop filter was used for EMG signal pre-processing and the rec

The importance of sexual selection in population divergence is of much interest, mainly because it is thought to cause reproductive isolation and hence could lead to speciation. Sexually selected traits have been hypothesized to diverge faster between populations than other traits, presumably because of differences in the strength, mechanism or dynamics of selection. We investigated this by quanti

We present a capacitance-voltage study for arrays of vertical InAs nanowires. Metal-oxide-semiconductor (MOS) capacitors are obtained by insulating the nanowires with a conformal 10 nm HfO2 layer and using a top Cr/Au metallization as one of the capacitor's electrodes. The described fabrication and characterization technique enables a systematic investigation of the carrier density in the nanowire

The content of the globular domains G1, G2 and G3 on the core protein of high-density (A1D1) aggrecan isolated from newborn and mature bovine cartilage and from cultures of bovine chondrocytes was examined. Quantitation based on the 220 nm absorbance of tryptic marker peptides from each domain isolated by reversed-phase HPLC showed that while the content of G1 and G2 was essentially the same for a

Simulations with the Explicit Microphysics Model (EMM) of a case of lightly precipitating, glaciated stratiform cloud are presented. This frontal cloud was observed by the UK Met Office C-130 aircraft and the dual-polarization radar at Chilbolton in southern England. The Hallett-Mossop (H-M) process was found to cause extremely high number concentrations of crystal columns of up to almost 1000 1(-

The paper presents a design and discusses configuration aspects of an overlay transport protocol based on an idea of the peer-to-peer direct and anonymous distribution overlay (P2PRIV). We estimate a secure configuration of the protocol and examine a correlation between the P2PRIV’s anonymous path lengths and latency. An increase of the path lengths speaks strongly in favor of the parallel solutio

BACKGROUND. Leiomyosarcoma of soft tissue is a rare tumor. There are different opinions regarding epidemiology and prognosis. METHODS. Epidemiology and prognosis were analyzed in a consecutive, population-based series of 48 patients with subcutaneous and deep-seated leiomyosarcoma in the extremities and trunk wall with a complete follow-up of a minimum of 3 years. Cutaneous tumors were not include

T Strain DSM 17733(T), isolated from the shore of Lake Abjata in Ethiopia, is a heterotrophic, alkaliphilic, moderately halophilic, Gram-positive, strictly aerobic, non-motile, non-endospore-forming bacterium. The organism grows optimally at 30-37 degrees C, pH 9 and 3 % (w/v) NaCl. Analysis of the cell wall showed the presence of murein of the type L-Lys-Gly-L-Glu, variation A4 alpha. The G + C c

The inverse scattering problem for the Schrodinger operator on the half-axis is studied. It is shown that this problem can be solved for the scattering matrices with arbitrary finite phase shift on the real axis if one admits potentials with long-range oscillating tails at infinity. The solution of the problem is constructed with the help of the Gelfand-Levitan-Marchenko procedure. The inverse pro

Background: The 65-kD isoform of glutamic acid decarboxylase (GAD) is a major autoantigen in patients with type 1 diabetes mellitus. This trial assessed the ability of alum-formulated GAD (GAD-alum) to reverse recent-onset type 1 diabetes in patients 10 to 18 years of age. Methods: We randomly assigned 70 patients with type 1 diabetes who had fasting C-peptide levels above 0.1 nmol per liter (0.3