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Which patient groups should be asked to participate in first-in-human trials of stem-cell-based therapies?

The aims of this article are to consider (1) whether there are medical and societal differences among diseases regarding which patient groups should be asked to participate in first-in-human (FIH) trials of stem-cell-based therapies; (2) any differences in the light of values generally endorsed by different types of ethical theories, since the question in the title of this article is value laden,

Pontiacs revansch

Om indianhövdingen Pontiac i amerikansk historieskrivning och bilmärket som var döpt efter honom.

End to end delays in a catenet environment

This paper presents a hierarchical model for a catenet environment. The model consists of three levels of models, and it reflects the end to end delay between two host computers each connected to a different LAN. The two LANs are connected via gateways by a WAN. The model incorporates a basic flow control mechanism, standardized local area network behaviour, as well as gateway functions in terms o

Hierarchical Variance Reduction Techniques for Monte Carlo Rendering

Ever since the first three-dimensional computer graphics appeared half a century ago, the goal has been to model and simulate how light interacts with materials and objects to form an image. The ultimate goal is photorealistic rendering, where the created images reach a level of accuracy that makes them indistinguishable from photographs of the real world. There are many applications ñ visualizati

Control of Preferences in Social Networks

We consider the problem of deriving optimal marketing policies for the spread of innovations in a social network. We seek to compute policies that account for i) endogenous network influences, ii) the presence of competitive firms, that also wish to influence the network, and iii) possible uncertainties in the network model. Contrary to prior work in optimal advertising, which also accounts for ne

Physical activity increases bone mass during growth.

BACKGROUND: The incidence of fragility fractures has increased during the last half of the 1990's. One important determinant of fractures is the bone mineral content (BMC) or bone mineral density (BMD), the amount of mineralised bone. If we could increase peak bone mass (the highest value of BMC reached during life) and/or decrease the age-related bone loss, we could possibly improve the skeletal

Recurrent and multiple bladder tumors show conserved expression profiles.

BACKGROUND: Urothelial carcinomas originate from the epithelial cells of the inner lining of the bladder and may appear as single or as multiple synchronous tumors. Patients with urothelial carcinomas frequently show recurrences after treatment making follow-up necessary. The leading hypothesis explaining the origin of meta- and synchronous tumors assumes a monoclonal origin. However, the genetic