Alzheimer's disease (AD) is the most common neurodegenerative disease and is characterized by the aggregation of β-amyloid (Aβ) and tau in the brain. Breakthroughs in disease-modifying treatments targeting Aβ bring new hope for the management of AD. But to effectively modify and someday even prevent AD, a better understanding is needed of the biological mechanisms that underlie and link Aβ and tau

EU law has developed with close ties to economic growth, and relatedly, various scholars have historically expressed critiques which would today be considered part of the Law and Political Economy approach. What is starkly absent from the relevant critiques is the way in which EU law regulates the migration phenomenon and its relation to the market. Migration law scholarship has been focusing on t

Study region: The NekooAbad Irrigation District in central Iran faces challenges due to inefficient surface water distribution. 82 million m3 of groundwater is extracted annually from 15,000 tube-wells, leading to decreased groundwater levels and increased energy consumption of 234 million kWh per year. Study focus: This study explores implementing automation in surface water distribution to reduc

Gastric cancer represents a serious health problem worldwide, with insufficient molecular biomarkers and therapeutic options. Consequently, several efforts have been directed towards finding specific disease markers in order to develop new therapies capable of defeating gastric cancer. Attention has been pointed to cancer stem cells (CSCs) as they are primarily responsible for tumor initiation and

Cardiovascular disease (CVD) is the leading cause of mortality and morbidity worldwide. While sociodemographic, dietary and lifestyle factors have been well documented in relation to CVD, environmental factors have been less studied. However, considering the ongoing biodiversity, climate, and health crises, it is imperative to better understand the interplay between the environment and health. Thi

The Sensory Processing Measure, second edition (SPM-2), is an American assessment guiding person-centered sensory processing interventions, but it lacks Swedish adaptation for occupational therapists. In eight phases, this study translated the SPM-2 into Swedish and assessed its face validity and preliminary psychometric properties, including internal consistency and inter-scale/item correlations.

Western Europe boasts advanced health care systems, robust kidney care guidelines, and a well-established health care workforce. Despite this, significant disparities in kidney replacement therapy incidence, prevalence, and transplant access exist. This paper presents the third International Society of Nephrology Global Kidney Health Atlas's findings on kidney care availability, accessibility, aff

Recent epidemiological studies have suggested a positive association between ultra-processed food consumption and breast cancer risk, although some studies also reported no association. Furthermore, the evidence regarding the associations between intake of food with lower degrees of processing and breast cancer risk is limited. Thus, we investigated the associations between dietary intake by degre

Vi som bor och jobbar i byggnader har en stor inverkan på hur mycket energi som de förbrukar. Genom att tydligt förmedla engagerande information till oss kan vi påverkas och göra energimedvetna val i våra hem genom förändringar i ventilationssystem. Att spara energi blir allt viktigare i vårt samhälle. Byggnader och fastigheter står för en betydande del av energiförbrukningen i Sverige, så det är Energy efficiency is becoming a more important part of our energy system. There is a need to investigate energy efficiency measures in the building and real estate sector, which accounts for a significant portion of the total energy consumption in Sweden. Therefore, this study investigates the energy-saving opportunities available to improve energy efficiency in this sector, with a focus on ventil

Bakgrund: Akne är en vanlig hudåkomma, som drabbar många tonåringar. Tonåren innebär en sårbar period i livet, med stora förändringar både psykiskt och fysiskt. Tidigare forskning visar att hudproblem kan få konsekvenser gällande självkänsla och psykiskt mående. Distriktssköterskan kan vara den första som möter tonåringar med akne och har därmed en viktig roll i att förmedla kunskap kring ämnet oc

Glioblastoma is our most common and most fatal primary brain tumor. Although continuous progress in the cancer research-field the prognosis for glioblastoma remains detrimental. Radiotherapy is a corner stone in the treatment arsenal and can induce an immune response, needed to achieve better tumor control. A limitation that remains is the side-effects on healthy tissue. The new implementation of

Det tog många år innan Svenska kyrkan på nationell nivå kunde redovisa statistik om delar av församlingarnas diakonala arbete. Införandet av diakonistatistik har mött motstånd, men flera aktörer samlar också egen statistik vid sidan av den nationella verksamhetsstatistiken.

The current literature on resilience shows a trend toward a dynamic process conceptualization, moving away from the previous trait-approach. However, the term “dynamic” is increasingly treated as a buzzword and is thereby oversimplified in the literature. The aim of this article is to develop a unified language pertaining to resilience as a dynamic process, so as to ensure progress in this field.

Bioelectronics holds great potential as therapeutics, but introducing conductive structures within the body poses great challenges. While implanted rigid and substrate-bound electrodes often result in inflammation and scarring in vivo, they outperform the in situ-formed, more biocompatible electrodes by providing superior control over electrode geometry. For example, one of the most researched met

Turkey’s state broadcaster TRT has produced a clip mocking Iran’s Crown Prince Reza Pahlavi and distorting historical facts about his father, the late Shah Mohammad Reza Pahlavi. The Shah’s legacy includes significant economic growth, modernization, and a substantial reduction in poverty in Iran. Given Turkey’s own human rights issues under President Erdoğan, there is a clear irony in TRT’s critic

The extraordinary diversity of flowering plants has long captivated biologists andevolutionary ecologists. Plant-insect relationships are recognized as a major driverof this diversity, with pollinators playing a crucial role in angiosperm speciation andtrait diversification. Numerous observational and experimental studies have shownthat pollinators influence the evolution of floral traits—such as

Background & aims: Epidemiological evidence on ultra-processed food (UPF) and cause-specific mortality remains limited and mixed. Molecular mechanisms underlying UPF intake and mortality remain unexplored. This study aimed to evaluate the associations between UPF consumption, metabolic signatures, and all-cause, premature, and cause-specific mortality. Methods: This study included 27670 partic

This paper presents the results of the 2022 Groundwater Time Series Modelling Challenge, where 15 teams from different institutes applied various data-driven models to simulate hydraulic-head time series at four monitoring wells. Three of the wells were located in Europe and one was located in the USA in different hydrogeological settings in temperate, continental, or subarctic climates. Participa