Background: The protein C anticoagulant system plays a key role in maintaining the hemostatic balance. Although several studies have identified thrombomodulin gene (THBD) variants among venous thromboembolism (VTE) patients, the role of THBD in relation to VTE in humans remains to be clarified. Objectives: This study aimed to determine the thrombotic risk of rare and common THBD variants in a larg

Long-term survival after childhood cancer often comes at the expense of late, adverse health conditions. However, survivorship care is frequently not available for adult survivors in Europe. The PanCareFollowUp Consortium therefore developed the PanCareFollowUp Care Intervention, an innovative person-centred survivorship care model based on experiences in the Netherlands. This paper describes the

Objective Lupus nephritis (LN) is a common and severe manifestation of SLE. The genetic risk for nephritis and progression to end-stage renal disease (ESRD) in patients with LN remains unclear. Herein, we aimed to identify novel genetic associations with LN, focusing on subphenotypes and ESRD. Methods We analysed genomic data on 958 patients with SLE (discovery cohort: LN=338) with targeted sequen

PURPOSE: Dynamic glucose-enhanced (DGE) MRI relates to a group of exchange-based MRI techniques where the uptake of glucose analogues is studied dynamically. However, motion artifacts can be mistaken for true DGE effects, while motion correction may alter true signal effects. The aim was to design a numerical human brain phantom to simulate a realistic DGE MRI protocol at 3T that can be used to as

Nondisplaced or minimally displaced femoral neck fractures are commonly treated with internal fixation, because of its less invasive and less time-consuming nature, as well its retention of the biological properties of the hip. Internal fixation with screws or pins is the current clinical routine in Sweden. However, the authors of some recent studies in elderly patients have suggested that the use

As capitalist society remains incapable of addressing climate breakdown, one measure is waiting in the wings: solar geoengineering. No other technology can cut global temperatures immediately. It would alleviate the symptoms of the crisis, not its causes. But might it be combined with radical emissions cuts? This essay, the first instalment of two, scrutinises the rationalist-optimist case for geo

At an archaeological excavation in central Lund in the early 1970s a very unusual find was retrieved: a piece of lead with several imprints from a coin die. The motif and the runic inscription on the lead plate indicate that the die derives from Sven Estridsen during his late years as king of Denmark. The find is quite unique. Early coin dies and imprints from coin dies are rare finds in the area

In current viking-age studies, slaves are brought forward as the main commodity creating the flow of dirhams from Islamic regions to Eurasia and Scandinavia. This article instead stresses Pre-Viking and later fur hunting as the primary factor driving the Svear and other Scandinavian peoples eastwards and it presents the geographical and economic shifts in the eastern fur trade from the 7th century

BACKGROUND: Traditional models to predict intensive care outcomes do not perform well in COVID-19. We undertook a comprehensive study of factors affecting mortality and functional outcome after severe COVID-19.METHODS: In this prospective multicentre cohort study, we enrolled laboratory-confirmed, critically ill COVID-19 patients at six ICUs in the Skåne Region, Sweden, between May 11, 2020, and M

This study critically engages with the knowledge produced in the field of gender-based violence (GBV) in the context of migration. The focus is specifically on empirical studies that look at women whose immigrant status is precarious, which means that their pathway to citizenship is uncertain and dependent on others. Some examples are migrant women students, asylum claimants and refused asylum cla

Due to the changing landscapes of higher education, a large body of research has studied how scholars make sense of academic identities and careers. Yet, little is known about how academics actually ‘work’ on their identities to navigate normative demands and complex career structures. This paper explores how scholars negotiate career scripts trough identity work. Drawing upon 35 interviews with eDue to the changing landscapes of higher education, a large body of research has studied how scholars make sense of academic identities and careers. Yet, little is known about how academics actually ‘work’ on their identities to navigate normative demands and complex career structures. This paper explores how scholars negotiate career scripts trough identity work. Drawing upon 35 interviews with e

Background: The Ponseti method is the gold standard for clubfoot treatment. However, relapse and residual gait deviations are common, and follow-up until 7 years of age is recommended. We evaluated the reliability of the foot drawing method, a new instrument for the follow-up of clubfoot. The method uses drawings of the foot in the neutral position and external rotation to measure foot length and