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Caseload midwifery for women with fear of birth is a feasible option

Objective: Continuity with a known midwife might benefit women with fear of birth, but is rare in Sweden. The aim was to test a modified caseload midwifery model of care to provide continuity of caregiver to women with fear of birth. Methods: A feasibility study where women received antenatal and intrapartum care from a known midwife who focused on women's fear during all antenatal visits. The stu

Ultrasonic Additive Manufacturing as a form-then-bond process for embedding electronic circuitry into a metal matrix

Ultrasonic Additive Manufacturing (UAM) is a hybrid manufacturing process that involves the layer-by-layer ultrasonic welding of metal foils in the solid state with periodic CNC machining to achieve the desired 3D shape. UAM enables the fabrication of metal smart structures, because it allows the embedding of various components into the metal matrix, due to the high degree of plastic metal flow an

Recent upgrades of the neutron reflectometer D17 at ILL

The vertical sample-plane reflectometer D17 at the Institut Laue–Langevin in Grenoble, France, has undergone several major upgrades since its commissioning, which are summarized in this article. The three major improvements are (i) a new focusing guide, increasing the usable flux on the sample by a factor of 2.5; (ii) a new beam polarizer and new spin flippers, allowing for the use of polarized ne

Macrophage-derived lipocalin-2 transports iron in the tumor microenvironment

While the importance of iron for tumor development is widely appreciated, the exact sources of tumor-supporting iron largely remain elusive. The possibility that iron might be provided by stromal cells in the tumor microenvironment was not taken into account so far. In the present study, we show that tumor-associated macrophages (TAM) acquire an iron-release phenotype upon their interaction with t

Targeting Neuroinflammation to Treat Alzheimer’s Disease

Over the past few decades, research on Alzheimer’s disease (AD) has focused on pathomechanisms linked to two of the major pathological hallmarks of extracellular deposition of beta-amyloid peptides and intra-neuronal formation of neurofibrils. Recently, a third disease component, the neuroinflammatory reaction mediated by cerebral innate immune cells, has entered the spotlight, prompted by finding

Nitrogen leaching from natural ecosystems under global change : A modelling study

To study global nitrogen (N) leaching from natural ecosystems under changing N deposition, climate, and atmospheric CO2, we performed a factorial model experiment for the period 1901-2006 with the N-enabled global terrestrial ecosystem model LPJ-GUESS (Lund-Potsdam-Jena General Ecosystem Simulator). In eight global simulations, we used either the true transient time series of N deposition, climate

Stochastic gene expression in Arabidopsis thaliana

Although plant development is highly reproducible, some stochasticity exists. This developmental stochasticity may be caused by noisy gene expression. Here we analyze the fluctuation of protein expression in Arabidopsis thaliana. Using the photoconvertible KikGR marker, we show that the protein expressions of individual cells fluctuate over time. A dual reporter system was used to study extrinsic

Transverse expansion of the electron sheath during laser acceleration of protons

The transverse expansion of the electrostatic sheath during target normal sheath acceleration of protons is investigated experimentally using a setup with two synchronized laser pulses. With the pulses spatially separated by less than three laser spot diameters, the resulting proton beam profiles become elliptical. By introducing a small intensity difference between the two pulses, the ellipses ar

Mapping the dominant regions of the phase space associated with c c - production relevant for the prompt atmospheric neutrino flux

We present a detailed mapping of the dominant kinematical domains contributing to the prompt atmospheric neutrino flux at high neutrino energies by studying their sensitivity to the cuts on several kinematical variables crucial for charm production in cosmic ray scattering in the atmosphere. This includes the maximal center-of-mass energy for proton-proton scattering, the longitudinal momentum fra

Do GSTM1 and GSTT1 polymorphisms influence the risk of developing mitochondrial diseases in a Tunisian population?

Mitochondria play an essential role to supply the cell with metabolic energy in the form of adenosine triphosphate (ATP) through oxidative phosphorylation (OXPHOS). As a consequence, they are also the primary source of cellular reactive oxygen species (ROS) which can cause oxidative damage of individual respiratory chain complexes. Indeed, affected OXPHOS subunits result in decreases in ATP produc

Bringing Environmentalism Home: Children’s Influence on Family Consumption in the Nordic Countries and Beyond

This article discusses children as contributors to sustainable ecological development. The aim of the article is to develop a framework for researching two questions: What are the prerequisites for children to become responsible environmentalists? What actual and potential influence do children have on their family’s consumption? Three theoretical perspectives are elaborated in relation to relevan