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The Eae2 locus on mouse chromosome 15 controls the development of experimental autoimmune encephalomyelitis (EAE); however, in this study we show that it also controls collagen-induced arthritis (CIA). To find the smallest disease-controlling locus/loci within Eae2, we have studied development of CIA in 676 mice from a partially advanced intercross. Eae2 congenic mice were bred with mice congenic
The European hummingbird hawkmoth, Macroglossum stellatarum (Linnaeus 1758), drinks nectar while hovering in front of flowers of all colours, odours, sizes and shapes. Naive moths orient predominantly towards visual stimuli and prefer blue flowers with a radial pattern and a central contrasting spot. Hummingbird hawkmoths have trichromatic colour vision and can learn any colour and different patte
Background: Smoking in pregnancy is a well-documented risk factor for fetal growth impairment and poor perinatal outcomes. Less is known about the long-term effects of maternal smoking on offspring mortality. Methods: A follow-up study in national registers on total mortality and cancer based on a birth cohort from Helsingborg, Sweden, including data on 2,010 sons and 1,982 daughters born to mothe
Background: The role of glycemic index (GI) in appetite and body-weight regulation is still not clear. Objective: The objective of the study was to investigate the long-term effects of a low-fat, high-carbohydrate diet with either low glycemic index (LGI) or high glycemic index (HGI) on ad libitum energy intake, body weight, and composition, as well as on risk factors for type 2 diabetes and isc
A new type of triangular phase diagram has been developed in which both the volume fractions and the shrinkage modes can be visualised and compared for the consolidation process in the paper dryer. The triangular phase diagrams show the development of the solid, the liquid and the gas volume fractions as well as the shrinkage relative to either ideal or no shrinkage of the sheets. Analysis showed
Ancient Italic terracottas were painted before or after firing depending on their function, as suggested by previous analyses. However, concerning the votive terracottas, there seems to have been no anlayses carried out, suggesting either a fired or non fired paint. Methods and problems associated with an ongoing research on some votive terracottas from Tessennano in Southern Etruria are considere
L-DOPA-induced dyskinesia (LID) is among the motor complications that arise in Parkinson's disease (PD) patients after a prolonged treatment with L-DOPA. To this day, transcriptome analysis has been performed in a rat model of LID [Neurobiol. Dis., 17 (2004), 219] but information regarding the proteome is still lacking. In the present study, we investigated the changes occurring at the protein lev
Benzene-fluorobenzene complexes are used as model systems to simulate the interactions of the SBB-HCAII protein-ligand complex. Using the second-order Moller-Plesset [MP2] and the coupled cluster singles and doubles including connected triple excitations models recently implemented with Cholesky decompositions we evaluate accurate interaction energies for several benzene-fluorobenzene van der Waal
Synthetic peptides composed of multiples of the consensus heparin-binding Cardin and Weintraub sequences AKKARA and ARKKAAKA are antimicrobial. Replacement of lysine and arginine by histidine in these peptides completely abrogates their antimicrobial and heparin-binding activities at neutral pH. However, the antibacterial activity against Gram-negative (Escherichia coli, Pseudomonas aeruginosa) an
