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Stress-related challenges in pentose fermentation to ethanol by the yeast Saccharomyces cerevisiae.

Conversion of agricultural residues, energy crops and forest residues into bioethanol requires hydrolysis of the biomass and fermentation of the released sugars. During the hydrolysis of the hemicellulose fraction, substantial amounts of pentose sugars, in particular xylose, are released. Fermentation of these pentose sugars to ethanol by engineered Saccharomyces cerevisiae under industrial proces

Human isolates of Listeria monocytogenes in Sweden during half a century (1958-2010)

Isolates of Listeria monocytogenes (n = 932) isolated in Sweden during 1958-2010 from human patients with invasive listeriosis were characterized by serotyping and pulsed-field gel electrophoresis (PFGE) (AscI). Of the 932 isolates, 183 different PFGE types were identified, of which 83 were each represented by only one isolate. In all, 483 serovar 1/2a isolates were distributed over 114 PFGE types

Force chains in monodisperse spherical particle assemblies: Three-dimensional measurements using neutrons.

The full triaxial stress state within individual particles in a monodisperse spherical granular assembly has been measured. This was made possible by neutron imaging and computed tomography combined with neutron diffraction strain measurement techniques and associated stress reconstruction. The assembly in question consists of 549 precision steel ball bearings under an applied axial load of 85 MPa

The Effect of Baseline Testosterone on the Efficacy of Degarelix and Leuprolide: Further Insights From A 12-Month, Comparative, Phase III Study in Prostate Cancer Patients

OBJECTIVE To investigate the effects of baseline testosterone on testosterone control and prostate-specific antigen (PSA) suppression using data from a phase III trial (CS21) comparing degarelix and leuprolide in prostate cancer. METHODS In CS21, patients with histologically confirmed prostate cancer (all stages) were randomized to degarelix 240 mg for 1 month followed by monthly maintenance doses

Janus molecularly imprinted polymer particles

By combining the specific molecular recognition capability of MIPs and the asymmetric structure of Janus particles, the Janus MIP particles which were synthesized via a wax-water Pickering emulsion showed attractive capabilities as self-propelled transporters for controlled drug delivery.

Role of the ProteinTyrosine Phosphatase SHP-I in Interleukin-6 Regulation of Prostate Cancer Cells

BACKGROUND. Interleukin-6 (IL-6) is a multifunctional cytokine that has been implicated in the modulation of growth and progression of prostate cancer. Decreased expression of the tyrosine phosphatase SHP-1, involved in regulation of cytokine and tyrosine kinase receptor signaling, has been shown to be associated with less favorable outcome among prostate cancer patients. METHODS. Parental LNCaP c

A simple and fast kinetic assay for phytases using phytic acid-protein complex as substrate.

Phytase (EC 3.1.3.-) hydrolyzes phytate (IP6) present in cereals and grains to release inorganic phosphate (Pi), thereby making it bioavailable. The most commonly used method to assay phytase, developed nearly a century ago, measures the Pi liberated from IP6. This traditional end point assay is time consuming and well known for its cumbersomeness in addition to requiring extra caution for handlin

Estimating the effects of the container revolution on world trade

Many historical accounts have asserted that containerization triggered complementary technological and organizational changes that revolutionized global freight transport. We are the first to suggest an identification strategy for estimating the effects of the container revolution on world trade. Our empirical strategy exploits time and cross-sectional variation in countries’ first adoption of con

Search for an aetiological virus candidate in chronic lymphocytic leukaemia by extensive transcriptome analysis

As an approach to determining the aetiology of chronic lymphocytic leukaemia (CLL), we searched for a virus expressed in human CLL B-cells by combining high-throughput sequencing and digital subtraction. Pooled B-cell mRNA transcriptomes from five CLL patients and five healthy donors were sequenced with 454 Life Sciences technology. Human reads were excluded by BLAST (Basic Local Alignment Search

3D GIS for Cultural Heritage Restoration : a 'white box' workflow

Structures of Architectural Heritage are constantly exposed to natural and human-made threats that can compromise their cultural and artistic values. This is the case of the Roman city of Pompeii, whose preserving conditions nowadays are so critical to let a group of Unesco-appointed experts consider the possible inscription of the property on the list of “World Heritage in Danger”. In this respec

Global, regional, and national incidence, prevalence, and years lived with disability for 301 acute and chronic diseases and injuries in 188 countries, 1990-2013: a systematic analysis for the Global Burden of Disease Study 2013

Background Up-to-date evidence about levels and trends in disease and injury incidence, prevalence, and years lived with disability (YLDs) is an essential input into global, regional, and national health policies. In the Global Burden of Disease Study 2013 (GBD 2013), we estimated these quantities for acute and chronic diseases and injuries for 188 countries between 1990 and 2013. Methods Estimate

Energy and Mass Exchange and the Productivity of Main Siberian Ecosystems (from Eddy Covariance Measurements). 1. Heat Balance Structure over the Vegetation Season

Direct measurements of heat balance (latent heat and sensible heat fluxes) by the eddy covariance method, undertaken in 1998-2000 and 2002-2004, are used to obtain information on the daily, seasonal, and annual dynamics of energy and mass exchange between the atmosphere and the typical ecosystems of Siberia (middle taiga pine forest, raised bog, and true four grass steppe with data for typical tun

Memory Behavior of the Planar Hall Effect in Ferromagnetic (Ga, Mn)As/GaAs Superlattices

The planar Hall effect (PHE) has been studied in short period (Ga, Mn)As/GaAs superlattices displaying a ferromagnetic interlayer coupling between the magnetic layers. Complex dependence of the PHE on applied magnetic field is explained by taking into account the magnetocrystalline anisotropy of the (Ga, Mn)As layers, which results from biaxial compressive strain in the layers epitaxially grown on

Origin of Swedish hemophilia B mutations

Background More than 1100 mutations that cause hemophilia B (HB) have been identified. At the same time, specific F9 mutations are present at high frequencies in certain populations, which raise questions about the origin of HB mutations. ObjectivesTo describe the mutation spectrum of all HB families in Sweden and investigate if mutations appearing in several families are due to independent recurr

Review of Cognitive Behavioral Therapy with Children: A Guide for the Community Practitioner

Cognitive behavioral therapy with children: A guide for the community practitioner by K. Manassis (see record 2009-01291-000). This book is a clearly written and concise guide for therapists who may have had some exposure to a manualized CBT program for children, but have had little formal training or supervision in CBT. While there is a heavy focus on anxiety and depression, the book is really ab