The coastal zone of Norrbotten, northern Sweden, was gradually inundated by the Ancylus Lake following the retreating ice margin and forming a highest coastline approximately 210 m above the present sea level. The succeeding shore displacement is reconstructed based on lithological investigations and radiocarbon datings of identified isolation sequences from 12 cored lake basins. The highest lake

We consider the origin of the anomalously high intensity of theultraviolet Fe II lambda 2507/2509 A lines observed with high spatialand spectral resolutions from gas blobs (GBs) near Carinae. This rareeffect in stellar spectra is attributable to a combination of severalfactors: (1) the high hydrogen density (>10^{8} cm^{-3}) that ensuresthe blocking of the Lyman continuum by GBs and, accordingly,

AIMS/HYPOTHESIS: Type 1 diabetes in children is characterised by autoimmune destruction of pancreatic beta cells and the presence of certain risk genotypes. In adults the same situation is often referred to as latent autoimmune diabetes in adults (LADA). We tested whether genetic markers associated with type 1 or type 2 diabetes could help to discriminate between autoimmune and non-autoimmune diab

A new experimental model, the two-tracer method (TTM), based on the planar laser-induced fluorescence technique (PLIF), is presented for the measurement of the local concentration of a fluorescent tracer in the liquid phase of a bubbly two-phase system. Light scattering and shading effects due to the bubbles were compensated for using the new model. The TTM results were found to give more accurate

The genes man26a and man2A from Cellulomonas fimi encode mannanase 26A (Man26A) and -mannosidase 2A (Man2A), respectively. Mature Man26A is a secreted, modular protein of 951 amino acids, comprising a catalytic module in family 26 of glycosyl hydrolases, an S-layer homology module, and two modules of unknown function. Exposure of Man26A produced by Escherichia coli to C. fimi protease generates ac

Phosphodiesterases (PDEs) include a large group of structurally related enzymes that belong to at least seven related gene families (PDEs 1-7) that differ in their primary structure, affinity for cAMP and cGMP, response to specific effectors, sensitivity to specific inhibitors, and regulatory mechanism. One characteristic of PDE3s involves their phosphorylation and activation in response to insuli

Identification of antigens that elicit protective immunity is essential for effective vaccine development. We investigated the related surface proteins of group B Streptococcus, Rib and alpha, as potential vaccine candidates. Paradoxically, nonimmunodominant regions proved to be of particular interest as vaccine components. Mouse antibodies elicited by Rib and alpha were directed almost exclusivel

This paper analyses the potential biomass Supply in the 15 EU countries (EU15), 8 new member states and 2 candidate countries (ACC10), plus Belarus and the Ukraine. The objective of this study is to make a more detailed assessment of the potential in Europe than previously undertaken. For this purpose five scenarios were designed to describe the short-, medium- and long-term potential of biomass f

Anionic O2 derivatives of methyl 3-deoxy-3-(4-methylbenzamido)-1-thio-beta- d-galactopyranoside have been synthesized as inhibitors against galectin-3. The sulfate, H-phosphonate, and benzyl phosphate derivatives showed an increased affinity as compared to the parent unsubstituted galactopyranoside. Modeling revealed arginine-144 being pinched by the C3 benzamide and O2 anionic substituents in tha

We report a clear correspondence between changes in the Curie temperature and carrier density upon annealing in epitaxially grown (Ga,Mn)As layers with thicknesses in the range between 5 and 20 nm. The changes are dependent on the layer thickness, indicating that the (Ga,Mn)As-GaAs interface has importance for the physical properties of the (Ga,Mn)As layer. The magnetoresistance shows additional f

Abstract. Deliberate self-harm was studied in 14-year-old adolescents from four schools in southern Sweden with a test–retest design, using a nine-item version of the Deliberate Self-Harm Inventory. At Time 1, 40.2% of the adolescents indicated deliberate self-harm on at least one occasion compared with 36.5% at Time 2. Test–retest data showed high stability over periods of up to 2 months in durat

Solid state quantum computer hardware may be based on rare-earth-ion-doped crystals. The qubits can be encoded as nuclear spin states of an ensemble of, e.g., Pr3+ ions, randomly doped into a Y2SiO5 crystal. Two such qubits can control each other through the dipole blockade effect, and transfers between the two qubit states can be done at a high fidelity, despite the strongly inhomogeneous nature

We have used Doppler-free polarization spectroscopy, intermodulated fluorescence and intermodulated optogalvanic spectroscopy for measuring isotope shifts in 6 Ne lines connecting the 2p53s and 2p53p configurations. The measurements were performed on two different hollow cathodes. For the 5852, 5882, 5945, 5976, 6143 and 6164 A lines the 22Ne-20Ne isotope shift was found to be 2300(15), 1740(2), 1

The clinical spectrum of Trichomonas vaginalis infection varies from asymptomatic to mild, moderate or severe vaginitis. Nitric oxide and other reactive nitrogen radicals produced by immune effector cells are important cytotoxic and cytostatic mediators against several microorganisms including parasites. In the present study, inducible nitric oxide synthase (iNOS) and reactive nitrogen intermediat

Penetrative convection is discussed where the instability is driven by radiative heating of water below the temperature of maximum density. Convection of this type occurs in ice-covered freshwater lakes in late spring, when the snow cover vanishes and solar radiation is absorbed beneath the ice cover. The vertical temperature structure, bulk mixed layer scaling, and mixed layer deepening are exami

Recent ChIP experiments of human and mouse embryonic stem cells have elucidated the architecture of the transcriptional regulatory circuitry responsible for cell determination, which involves the transcription factors OCT4, SOX2, and NANOG. In addition to regulating each other through feedback loops, these genes also regulate downstream target genes involved in the maintenance and differentiation

Early age at menarche is a risk factor for breast cancer. A previous study reported a significant positive association between the CYP3A4*1B variant allele and early puberty. We investigated whether polymorphisms of the CYP3A4, CYP17, CYP1B1, and CYP1A2 genes predict the age at onset of menarche. Five hundred eighty-three nulliparous women between ages 17 and 35, of various ethnic backgrounds, com

Exposure of the skin to certain phenols or catechols such as 4-tert-butylphenol (TBP) and 4-tert-butylcatechol (TBC) may cause leukoderma. These substances are used in the polymer industry and numerous cases have been reported. Several theories of the mechanism for chemical leukoderma have been suggested. In the present study, TBP and TBC are shown to be oxidised by tyrosinase. The oxidation of TB