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Expression and Purification of Channel Proteins : Aiming at structural and functional understanding of TRPAs and Aquaporins

Every living cell is surrounded by a cell membrane that is made up of amphipathicphospholipids, separating the aqueous solutions inside and outside the cell with ahydrophobic barrier. This compartmentalization is a prerequisite for life, but so arethe many molecules that are floating in the membrane, altering its properties andconnecting the inside with the outside. An important group are the tran

Asymmetry in the atmosphere of the ultra-hot Jupiter WASP-76 b***

Context. WASP-76 b has been a recurrent subject of study since the detection of a signature in high-resolution transit spectroscopy data indicating an asymmetry between the two limbs of the planet. The existence of this asymmetric signature has been confirmed by multiple studies, but its physical origin is still under debate. In addition, it contrasts with the absence of asymmetry reported in the

K*(892)± resonance production in Pb-Pb collisions at sNN =5.02 TeV

The production of K∗(892)± meson resonance is measured at midrapidity (|y|8 GeV/c, consistent with measurements for other light-flavored hadrons. The smallest values are observed in most central collisions, indicating larger energy loss of partons traversing the dense medium. ©2024 CERN, for the ALICE Collaboration. Published by the American Physical Society under the terms of the Creative Commons

Origin of pathogenic variant and mosaicism in families with a sporadic case of haemophilia B

Introduction: Of newly diagnosed cases of haemophilia B, the proportion of sporadic cases is usually 50% of severe cases and 25% of moderate/mild cases. However, cases presumed to be sporadic due to family history may not always be sporadic. Few case reports have been published on mosaicism in haemophilia B. Aim: The present study aimed to trace the origin of the pathogenic variant in a well-defin

PARKIN is not required to sustain OXPHOS function in adult mammalian tissues

Loss-of-function variants in the PRKN gene encoding the ubiquitin E3 ligase PARKIN cause autosomal recessive early-onset Parkinson's disease (PD). Extensive in vitro and in vivo studies have reported that PARKIN is involved in multiple pathways of mitochondrial quality control, including mitochondrial degradation and biogenesis. However, these findings are surrounded by substantial controversy due

Spatial Theory in Planning Practice? : On the Concepts of Space that Made Urban Design a Planning Solution for Segregation in Malmö, Sweden

Studying the Sorgenfri urban renewal project in the Swedish city of Malmö, this article suggests that a shift in planning documents reflects a new understanding of segregation containing traces of arguments from theoretical debates in geography. This new understanding of segregation appears informed by geographic debates on encounters, mobility, and boundaries, and implies that segregation is best

‘Like a torch that enlightens new parents along a narrow and winding path into parenthood’ – Midwives' experiences by an interview study

Background: The core of postnatal care is that midwives recognise the needs of women and new-born babies and provide the highest possible quality of care and medical safety to optimise the health and well-being of new families. The study aimed to describe midwives' experiences in providing postnatal care for families during the first week after the birth of their baby. Methods: An interview study

Temperature-Dependent Selectivity and Detection of Hidden Carbon Deposition in Methane Oxidation

Reaction products in heterogeneous catalysis can be detected either on the catalyst surface or in the gas phase after desorption. However, if atoms are dissolved in the catalyst bulk, then reaction channels can become hidden. This is the case if the dissolution rate of the deposits is faster than their formation rate. This might lead to the underestimation or even overlooking of reaction channels

Chebyshev polynomials corresponding to a vanishing weight

We consider weighted Chebyshev polynomials on the unit circle corresponding to a weight of the form (z−1)s where s > 0. For integer values of s this corresponds to prescribing a zero of the polynomial on the boundary. As such, we extend findings of Lachance et al. (1979), to non-integer s. Using this generalisation, we are able to relate Chebyshev polynomials on lemniscates and other, more establi

Atrial Fibrillation and Clonal Hematopoiesis in TET2 and ASXL1

Importance: Clonal hematopoiesis of indeterminate potential (CHIP) may contribute to the risk of atrial fibrillation (AF) through its association with inflammation and cardiac remodeling. Objective: To determine whether CHIP was associated with AF, inflammatory and cardiac biomarkers, and cardiac structural changes. Design, Setting, and Participants: This was a population-based, prospective cohort

Neuroethology: Decoding the waggle dance

A new study combining high-speed video recordings and computational modeling has revealed an overlooked feature of the famous honeybee waggle dance, yielding the first biologically plausible neural circuit model of how the information transmitted via the waggle dance could be assimilated by the follower bees.

Experimental observation of a mode-1 instability driven by Landau cavities in a storage ring

Landau cavities used to lengthen the bunches in storage rings necessarily constitute a significant impedance. Because of the particular phase of the field required for bunch lengthening, they are often detuned quite considerably from resonance, more so than the main cavities. As a result, their impedance can excite the first coupled-bunch mode such that it becomes unstable. This phenomenon has pre

On Police, Criminals, and the Anthropological Games They Play

Many crimes build on the ability to blend into the scenery of everyday life—to become part of people’s regular routines, but with clandestine intentions. “Criminals,” in other words, often have an impressive anthropological capability. They are not just good at stealing stuff or cheating people. To commit a crime, they must first have a detailed understanding of the way people behave and live. The

Large eddy simulations of turbulent pipe flows at moderate Reynolds numbers

Wall-bounded turbulence is relevant for many engineering and natural science applications, yet there are still aspects of its underlying physics that are not fully understood, particularly at high Reynolds numbers. In this study, we investigate fully developed turbulent pipe flows at moderate-to-high friction velocity Reynolds numbers ( 361 ≤ R e τ ≤ 2000 ), corresponding to bulk velocity-based Re

Consumption of soft drinks and juices and risk of liver and biliary tract cancers in a European cohort

Purpose: The aim of the study was to assess associations between intake of combined soft drinks (sugar sweetened and artificially sweetened) and fruit and vegetable juices and the risk of hepatocellular carcinoma (HCC), intrahepatic bile duct (IHBC) and biliary tract cancers (GBTC) using data from the European Prospective Investigation into Cancer and Nutrition cohort of 477,206 participants from