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Selective vulnerability in neurodegeneration: insights from clinical variants of Alzheimer's disease.

Selective vulnerability in the nervous system refers to the fact that subpopulations of neurons in different brain systems may be more or less prone to abnormal function or death in response to specific types of pathological states or injury. The concept has been used extensively as a potential way of explaining differences in degeneration patterns and the clinical presentation of different neurod

Third trimester assessment of the uterine scar in women with prior caesarean: what is the evidence?

The increasing rate of caesarean delivery is a worldwide concern. A major contributor to this evolution has been a concomitantly decline in vaginal birth after caesarean, because of the risk of intrapartum uterine rupture, which is a rare but potentially catastrophic complication of a trial of labour after caesarean (TOLAC). On the other hand, elective repeat caesarean is associated with surgical

Effects of Walking Speed and Results of Timed Get-Up-and-Go Tests on Quality of Life and Social Participation in Elderly Individuals With a History of Osteoporosis-Related Fractures.

OBJECTIVE: To investigate the relationships between physical performance, quality of life (QoL), and social participation among elderly men and women with a history of osteoporosis-related fractures. METHOD: The study was a population-based cross-sectional study including 155 participants aged 60 to 93 years from the Swedish longitudinal investigation, "Good Aging in Skåne." The participants had s

A 12-bit 125-MHz segmented current-steering DAC for communication application

A 12-bit 125-MHz digital-to-analog converter (DAC) for communication application is designed. It is based on current-steering segmented architecture and modified Q2 random walk switching scheme to obtain 12-bit accuracy. A new voltage swing reduced driver (VSRD) is implemented to promote the dynamic performance. The DAC uses 0.18 µm 1.8 V standard digital CMOS technology. The die area (core) is 2.

Horizontal Environmental Assessment of Postponement Strategy – A Delphi-based Investigation

This paper is based on the findings of a research work by Abukhader and Jönson (2004a), who discuss the possibilities and limitations of the ties of postponement strategy in food supply chains. They identified the cases/examples (i.e. company cases) of application of postponement across the various categories of foods: frozen, chilled/fresh and long shelf life. The food industry nowadays is in nee

Enriched environment reduces apolipoprotein E (ApoE) in reactive astrocytes and attenuates inflammation of the peri-infarct tissue after experimental stroke.

Apolipoprotein E (ApoE), a cholesterol transporter and an immunomodulator, is brain protective after experimental stroke and implicated in brain repair. Here, we study the involvement of ApoE in the restoration of brain function after experimental stroke, by using animal housing conditions that differentially improve recovery after occlusion of the middle cerebral artery occlusion (MCAO). We found

Further results on binary convolutional codes with an optimum distance profile

Fixed binary convolutional codes are considered which are simultaneously optimal or near-optimal according to three criteria: namely, distance profiled, free distanced_{ infty}, and minimum number of weightd_{infty}paths. It is shown how the optimum distance profile criterion can be used to limit the search for codes with a large value ofd_{infty}. We present extensive lists of such robustly optim