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Huntington's disease (HD) is a devastating, inherited neurodegenerative disorder caused by an expanded CAG repeat in the huntingtin gene. Peripheral symptoms, such as skeletal muscle wasting, progressive weight loss, altered body composition and endocrine disturbances exist alongside neurodegeneration. Both the mutant gene and protein are expressed in cells and tissues throughout the body.Weight l
This paper presents simulation and measurement results for two 2-stage E-band power amplifiers implemented in 0.18um SiGe technology with fT = 200 GHz. To increase the power gain by mitigating the effect of the base-collector capacitance, the first design uses a differential cascode topology with a 2.7 V supply voltage. The second design instead uses capacitive cross-coupling of a differential com
This paper presents measurement results for a low supply voltage 28 GHz beam steering PLL, designed in a SiGe bipolar process with fT = 200 GHz. The PLL, designed around a QVCO, is intended for a beam steering 81-86 GHz E-band transmitter. Linear phase control is implemented by variable current injection into a Gilbert type phase detector, with a measured nominal phase control sensitivity of 2.5˚/This letter presents measurement results for a low supply voltage 28 GHz beam steering PLL, designed in a SiGe bipolar process with fT=200 GHz. The PLL, designed around a QVCO, is intended for a beam steering 81-86 GHz E-band transmitter. Linear phase control is implemented by variable current injection into a Gilbert type phase detector, with a measured nominal phase control sensitivity of 2.5 °/
In difference to certain other European countries, the European Court for Human Rights (ECtHR) is rarely discussed in critical terms in Swedish media or in contemporary legal and political debate in Sweden. The article identifies examples of sporadic critical appraisals of the ECtHR in case-law and in legal debate. Interestingly, no political parties represented in the Riksdag have expressed scept
In this essay we investigate ways to re-configure ethnographic practices and articulate them as diffractive. The essay problematizes the ways in which the phi- losophical concept of reflexivity can be understood as limiting for the inherent compositional character of ethnographic practices. These practices are by necessity carried out in proximity. That makes a reflexive point of departure problem
Harmonic task scheduling has many attractive properties, including a utilization bound of 100% under rate-monotonic scheduling and reduced jitter. At the same time, it places a severe constraint on the task period assignment for any application. In this paper, we explore the use of harmonic task scheduling for applications with multiple feedback control tasks. We investigate the properties of harm
In 2006 a genetic signal within the gene encoding transcription factor 7-like 2 (TCF7L2) was first reported to be associated with type 2 diabetes. Since then multiple genome-wide association studies have revealed this signal to be among the most strongest associations reported with this disease to date. Furthermore, multiple studies around the world have revealed the global relevance of this locus
Ensuring energy security and mitigating climate change are key energy policy priorities. The recent Intergovernmental Panel on Climate Change Working Group III report emphasized that climate policies can deliver energy security as a co-benefit, in large part through reducing energy imports. Here, using five state-of-the-art global energy-economy models and eight long-term scenarios, we show that w
Background: The time spent in nursing homes (NHs) by patients with Alzheimer’s disease (AD) might be influenced by many factors, e.g., sociodemographic and clinical characteristics, rate of disease progression, and concomitant disorders. Whether different aspects of cholinesterase inhibitor (ChEI) therapy (drug agent, dose, and duration) affect time spent in NHs has not been investigated. We studi
This study investigates how communication consultants struggle to reconstruct their professional role in the digital media landscape. The extant literature on professional roles in public relations has a tendency to render roles as static pregivens. Therefore, the purpose of this study is to contribute conceptually and empirically to role research by focusing on the process of “role-making” and ho
Heart transplantation (HTx) is severely limited by a shortage of donors. This thesis aimed to investigate the effectof variables used to match donors to recipients in HTx.Methods: Data from the ISHLT registry was used to study: I: Identical versus compatible non-identical ABOmatchingin 3,589 AB HTx recipients. II: Outcomes of 94 ABO-incompatible transplants were compared to anABO-compatible group.
