INTRODUCTION: Increasing evidence suggests that optimal food choice is critical for sizable prevention of western diseases such as cardiovascular disease and cancer. The Mediterranean diet is an important step in this direction. Moreover, substantially lower rates of Western disease, even compared to Mediterranean countries, have been observed among hunter-gatherers and other non-western populatio

The phosphatidylinositol 3-kinases-AKT-mammalian target of rapamycin pathway (PI3K/AKT/mTOR) is central in colorectal tumors. Data on its role in hereditary cancers are, however, scarce and we therefore characterized mutations in PIK3CA and KRAS, and expression of PIK3CA, phosphorylated AKT, and PTEN in colorectal cancers linked to hereditary nonpolyposis colorectal cancer (HNPCC). Sequencing was

We investigated implications of nitric oxide (NO) derived from islet neuronal constitutive NO synthase (ncNOS) and inducible NOS (iNOS) on insulin secretory mechanisms in the mildly diabetic GK rat. Islets from GK rats and Wistar controls were analysed for ncNOS and iNOS by HPLC, immunoblotting and immunocytochemistry in relation to insulin secretion stimulated by glucose or l-arginine in vitro an

BACKGROUND: Trauma induces transcapillary leakage of fluid and proteins because of increased microvascular permeability. Based on studies showing that prostacyclin (PGI2) has permeability-reducing properties, in the present study, we investigated whether PGI2 reduces plasma volume (PV) loss after a nonhemorrhagic trauma. METHODS: The study was performed on anesthetized Sprague-Dawley rats exposed

Purpose In numerous studies vigabatrin medication has been associated with visual field constriction and alterations in the full-field electroretinogram (ff-ERG), but it is not clear whether these changes are reversible or not. The purpose of this study was to examine patients with visual field loss and reduced ff-ERG several years after discontinuing vigabatrin therapy, in order to investigate re

BACKGROUND: Children with cerebral palsy (CP) often walk with a slower speed and a higher energy cost. Their walking performance and choice of mobility method may vary in different environments. Independent mobility is important for activity and participation. QUESTIONS/PURPOSES: We described walking performance at different distances and environments in relation to gross motor function, CP subtyp

B-cell development to antibody-producing plasma cells requires the concerted function of a large number of genes and proteins. Genome-level expression profiling during human B-cell maturation was studied in anti-immunoglobulin M-stimulated Ramos cells. cDNA microarrays were used to follow changes in the transcriptome over several days. Close to 1500 genes had significantly altered expression at le

CD40 is a cell surface receptor initially discovered on cells of the hemopoietic lineage. Its primary role on immune cells is to enhance their activation and hence their production of cytokines and immunomodulatory molecules. Recently, CD40 has also been detected on human fibroblasts. An emerging view of the fibroblast is that it is far more than a structural cell, being capable of intimate intera

The production of single charged and neutral intermediate vector bosons in e(+)e(-) collisions has been studied in the data collected by the DELPHI experiment at LEP at centre-of-mass energies between 183 and 209 GeV, corresponding to an integrated luminosity of about 640 pb(-1). The measured cross-sections for the reactions, determined in limited kinematic regions, are in agreement with the Stand

We compare a vector finite-difference method that correctly applies the boundary conditions at both horizontal and vertical dielectric interfaces (but not at corners or slanted interfaces) to algorithms that only approximately satisfy these boundary conditions. We find, rather unexpectedly, that for strongly guiding waveguides the boundary conditions imposed at the refractive- index discontinuitie

Glass with low-a coatings based on SnO2 (usually referred to as hard coatings) provides a cost-effective replacement of one of the panes in ordinary double-pane windows. It considerably improves the energy efficiency of the window and at the same time preserves the appearance of,old hand-crafted windows. Adding a low refractive index anti-reflective (AR) coating on both sides of the low-a coated p

Second-generation bioethanol produced from various lignocellulosic materials, such as wood, agricultural or forest residues, has the potential to be a valuable substitute for, or a complement to, gasoline. One of the crucial steps in the ethanol production is the hydrolysis of the hemicellulose and cellulose to monomer sugars. The most promising method for hydrolysis of cellulose to glucose is by

I denna skrift ges en heltäckande beskrivning av de byggnadsfysikaliska förhållandena i konstruktioner med golv på mark. Olika fuktbelastningar och deras konsekvenser beskrivs i detalj. Stor vikt läggs vid att skapa förståelse för olika byggnadsfysikaliska samband, speciellt mellan värme och fukt. Vidare tillämpas fuktdimensioneringsmetodiken på tre noggrant beskrivna grundkonstruktioner

Simultaneous measurements of early flame speed and local measurements of the major parameters controlling the process are presented. The early flame growth rate was captured with heat release analysis of the cylinder pressure. The local concentration of fuel or residual gas were measured with laser induced fluorescence (LIF) on isooctane/3-pentanone or water. Local velocity measurements were perfo

We tested whether previous exposure to a toxic strain of cyanobacteria (Microcystis) affects survival, growth, and reproduction of a common herbivore, Daphnia magna. Samples from three natural populations of D. magna were each divided into two parts; one part was fed a mixture of toxic Microcystis and the non-toxic green alga Scenedesmus whereas the other part was fed only Scenedesmus. After four

This paper introduces a generalisation of the notion of singular value for Hilbert space operators to more general Banach spaces. It is shown that for a simple integral operator of Hardy type the singular values are the eigenvalues of a non-linear Sturm-Liouville equation and coincide with the approximation numbers of the operator. Finally, asymptotic formulas for the singular numbers are deduced.