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Ductus venosus blood flow velocity waveform in diabetic pregnancies

Objective Maternal diabetes during pregnancy is associated with congenital cardiac malformations and hypertrophic cardiomyopathy. Blood flow in the ductus venosus (DV) has been postulated to reflect cardiac function. The aim of our study was to investigate if diabetic pregnancies exhibit abnormal DV hemodynamics, hence indicating changes in fetal cardiac function. Methods The pulsatility index of

Cell periphery-related proteins as major genomic targets behind the adaptive evolution of an industrial Saccharomyces cerevisiae strain to combined heat and hydrolysate stress

Background: Laboratory evolution is an important tool for developing robust yeast strains for bioethanol production since the biological basis behind combined tolerance requires complex alterations whose proper regulation is difficult to achieve by rational metabolic engineering. Previously, we reported on the evolved industrial Saccharomyces cerevisiae strain ISO12 that had acquired improved tole

Collective and noncollective excitations in Te-122

High-spin states in Te-122 were populated in the reaction Se-82(Ca-48, alpha 4n) Te-122 at a beam energy of 200 MeV and gamma-ray coincidences weremeasured with the Gammasphere spectrometer. The previously known level scheme was extended to considerably higher spin. Maximally aligned states and several high-energy transitions feeding into some of these levels were observed. In addition, seven coll

Factors associated with young children’s self-perceived physical competence and self-reported physical activity.

The aim of this study was to identify factors associated with self-reported physical activity (PA), self-perceived physical fitness and competence in physical education (PE) among young children. The study included physical tests, anthropometric measures and a questionnaire. The study group comprised 206 children (114 boys and 92 girls, aged 8–12 years). Positive Odds Ratio was used in the logisti

Comparison of cisplatin sensitivity and the 18F fluoro-2-deoxy 2 glucose uptake with proliferation parameters and gene expression in squamous cell carcinoma cell lines of the head and neck

Background: The survival of patients with locally advanced head and neck cancer is still poor, with 5-year survival rates of 24-35%. The identification of prognostic and predictive markers at the molecular and cellular level could make it possible to find new therapeutic targets and provide "taylor made" treatments. Established cell lines of human squamous cell carcinoma (HNSCC) are valuable model

PHENIX measurements of 3D emission source function in Au-Au collisions at sqrt(s) = 200 GeV

A state-of-the-art 3D source imaging technique is used to extract the 3D two-pion source function in central and mid-central Au+Au collisions at GeV. The source function indicates a previously unresolved non-Gaussian tail in the directions of the pion pair transverse momentum (out) and along the beam (long). Model comparisons give robust estimates for several characteristics of the emission source

Evaluating Amyloid-beta Oligomers in Cerebrospinal Fluid as a Biomarker for Alzheimer's Disease

The current study evaluated amyloid-beta oligomers (A beta o) in cerebrospinal fluid as a clinical biomarker for Alzheimer's disease (AD). We developed a highly sensitive A beta o ELISA using the same N-terminal monoclonal antibody (82E1) for capture and detection. CSF samples from patients with AD, mild cognitive impairment (MCI), and healthy controls were examined. The assay was specific for oli

Experimental investigation on the effect of detail design on wood moisture content in outdoor above ground applications

An essential part of a performance-based service life design format for wood exposed in outdoor applications is the effect of proper detailing in terms of avoiding moisture traps. Models for predicting degradation and non-performance caused by decay are functions of arbitrary climate history of combined moisture content and temperature. Therefore it is crucial to be able to predict the behaviour o

Gene expression studies of pregastrulation development: the basement membrane is essential for cell differentiation

Basement membranes (BMs) are sheet-like structures of extracellular matrix. They act as a supporting structure but can also significantly influence cellular behavior in development, tissue homeostasis and disease. Laminins, a major BM component, are multidomain proteins, consisting of three polypeptide chains (α, β and γ). During pregastrulation development, stem cells convert and epithelial tissu

Associations between proteins and heavy metals in urine at low environmental exposures: Evidence of reverse causality

Heavy metals can cause renal effects on vulnerable populations but it is uncertain whether these metals still pose health risks at the low exposure levels now prevailing in most industrialized countries. In a cross-sectional study performed on 736 adolescents, we assessed the associations between the concentrations of cadmium and lead in blood and urine and the urinary concentrations of albumin an

Galectin-1-binding glycoforms of haptoglobin with altered intracellular trafficking, and increase in metastatic breast cancer patients.

Sera from 25 metastatic breast cancer patients and 25 healthy controls were subjected to affinity chromatography using immobilized galectin-1. Serum from the healthy subjects contained on average 1.2 mg per ml (range 0.7-2.2) galectin-1 binding glycoproteins, whereas serum from the breast cancer patients contained on average 2.2 mg/ml (range 0.8-3.9), with a higher average for large primary tumour

Storfjärilar som ökar sin utbredning: nytillskotten i storfjärilsfaunan i sydligaste Sverige under perioden 1973-2009

This study highlights the expansion of butterflies and macromoths occurring in southern Sweden. Recent changes in climate and habitat has been stressed as the main factors influencing changes in species distributions. Climate change implies an increase in temperature and some species are assumed to extend their northern ranges. In this study we compiled information about the first observations of

Att lära, att göra, att klara: Förmedling av datortekniska hjälpmedel till barn medsynnedsättning. Från förskrivning till vardaglig användning iskola och hem

Förmåga att använda informations- och kommunikationsteknik framhålls numera ofta som en förutsättning för delaktighet på lika villkor i samhällslivet. Nära förknippat med detta är de insatser som görs för att överbrygga digitala klyftor i samhället. IKT har gjort deltagandet i samhällslivet mer möjligt för personer med synnedsättning. Tillgång till teknik innebär dock inte alltid att den kan använ

Carbon routes from decomposing plant residues and living roots into soil food webs assessed with C-13 labelling

This field experiment investigated how C from fresh organic amendments and from a growing leek crop was allocated into different soil microbial and faunal groups in an arable field. A C-13-enriched red clover green manure was incorporated in one treatment, while the growing leek crop was pulse labelled with (CO2)-C-13 in another. Incorporation of C-13 into microbial fatty acids, micro- and macroar

The UTCI-Clothing Model

The Universal Thermal Climate Index (UTCI) was conceived as a thermal index covering the whole climate range from heat to cold. This would be impossible without considering clothing as the interface between the person (here, the physiological model of thermoregulation) and the environment. It was decided to develop a clothing model for this application in which the following three factors were con

Pre- and postoperative vomiting in children undergoing video-assisted gastrostomy tube placement.

Background. The aim of this study was to determine the incidence of pre- and postoperative vomiting in children undergoing a Video-Assisted Gastrostomy (VAG) operation. Patients and Methods. 180 children underwent a VAG operation and were subdivided into groups based on their underlying diagnosis. An anamnesis with respect to vomiting was taken from each of the children's parents before the operat

Possibilities of Using Fetal Hemoglobin as a Platform for Producing Hemoglobin-Based Oxygen Carriers (HBOCs).

The expression levels of fetal hemoglobin (HbF) in bacterial recombinant systems are higher compared with normal adult hemoglobin (HbA). However, heme disorientation in globins are often observed in recombinant production processes, both for HbA and HbF, although the degree of heme oriental disorder is much lower for HbF. In addition, the heme disorientation can be converted to a normal conformati