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THE HYPOXIC HEMATOPOIETIC STEM CELL NICHE Consequences of Hypoxia-induced Transcription on Stem Cell Fate
Popular Abstract in Swedish Stamceller är unika celler som har möjlighet att både förnya sig själva och ge upphov till en mängd mogna celler. Den ultimata stamcellen är det befruktade ägget, som är den cell som efter omfattande celldelning kommer att ge upphov till alla vävnader och celler i den färdigutvecklade kroppen. Dessa celler kallas därför pluripotenta. Även i den färdigutvecklade kroppen Hematopoiesis is the process of blood formation that originates with the hematopoietic stem cell (HSC), a cell type that is responsible for the life-long supply of mature blood cells. HSCs are defined by their ability to self-renew as well as giving rise to differentiated cells of all blood lineages. Because of these features, HSCs are also the basis for bone marrow transplantation regimens for tr
Fracture of the distal radius - outcome, primary surgery and treatment of malunion
A consensus protocol for treatment of distal radius fractures (DRF) has been developed to aid clinicians in treatment decision making. The protocol was evaluated in Paper I using a validated subjective outcome instrument, DASH in 518 consecutive patients. A good final subjective result was achieved with the proposed protocol, regardless of initial severity with a low median DASH score in all group
Measurement of dijet production in diffractive deep-inelastic scattering with a leading proton at HERA
The cross section of diffractive deep-inelastic scattering ep -> eXp is measured, where the system X contains at least two jets and the leading final state proton is detected in the H1 Forward Proton Spectrometer. The measurement is performed for fractional proton longitudinal momentum loss x(P) < 0.1 and covers the range 0.1 < vertical bar t vertical bar < 0.7 GeV2 in squared four-momentum transf
Nursing staff turnover at a Swedish university hospital: an exploratory study.
Aim. The aim was to explore opinions on individual needs and other factors that may influence nursing staff turnover. Background. High staff turnover is a great problem for many hospitals. It is shown to have a negative effect on the quality of nursing care and to increase hospital costs. Design. In 2004 in a large university hospital in Sweden five focus group discussions (FGDs) including departm
A Response to Honig and Samuelsson (2014)
Honig and Samuelsson (2014) recently published an article in this outlet criticizing “Does business planning facilitate the development of new ventures? “ a paper I wrote with Scott Shane nearly 15 years ago. They claim that their effort adds to the discussion of (a) the merits of business planning, (b) data replication and extension, (c) sample selection bias, (d) evaluation of normative research
Sternum wound contraction and distension during negative pressure wound therapy when using a rigid disc to prevent heart and lung rupture.
BACKGROUND: There are increasing reports of deaths and serious complications associated with the use of negative pressure wound therapy (NPWT), of which right ventricular heart rupture is the most devastating. The use of a rigid barrier has been suggested to offer protection against this lethal complication by preventing the heart from being drawn up against the sharp edges of the sternum. The aim
Do Employers Use Unemployment as a Sorting Criterion When Hiring? Evidence from a Field Experiment
The stigma associated with long-term unemployment spells could create large inefficiencies in labor markets. While the existing literature points toward large stigma effects, it has proven difficult to estimate causal relationships. Using data from a field experiment, we find that long-term unemployment spells in the past do not matter for employers' hiring decisions, suggesting that subsequent wo
Changes in ability, perceived difficulty and use of assistive devices in everyday life: a 4-year follow-up study in people with late effects of polio
Background - There are numbers of persons living in the community with late effects of polio, of which many develop new symptoms, but the course of progression is unclear. Objectives - To assess changes after 4 years in ability and perceived difficulty in persons with late effects of polio. Material and methods - Community dwelling persons from a polio clinic. Information was gathered by questionn
Conventional drainage versus four hour clamping drainage after total knee arthroplasty in severe osteoarthritis: a prospective, randomised trial
Total knee replacement in severe osteoarthritis usually requires extensive soft tissue releases often associated with considerable bleeding. In a prospective, randomised trial we compared postoperative conventional suction drainage versus four hour clamping drainage in 60 patients undergoing total knee arthroplasty for severe osteoarthritis. We compared blood loss, number of transfusions, postoper
Bortom New Public Management: Institutionell transformation i svensk sjukvard
Mussel farming can be used as a mitigation tool - Response
Stomatal uptake of O-3 in aspen and aspen-birch forests under free-air CO2 and O-3 enrichment
Rising atmospheric carbon dioxide (CO2) may alleviate the toxicological impacts of concurrently rising tropospheric ozone (O-3) during the present century if higher CO2 is accompanied by lower stomatal conductance (g,), as assumed by many models. We investigated how elevated concentrations of CO2 and O-3, alone and in combination, affected the accumulated stomatal flux of O-3 (AFst) by canopies an
Gut Microbiota and Inflammation
Systemic and local inflammation in relation to the resident microbiota of the human gastro-intestinal (GI) tract and administration of probiotics are the main themes of the present review. The dominating taxa of the human GI tract and their potential for aggravating or suppressing inflammation are described. The review focuses on human trials with probiotics and does not include in vitro studies a
A History of Swedish Experimental Film Culture : From Early Animation to Video Art
Mångfaldiga internationella perspektiv på strokevård
Den 18:e nordiska kongressen arrangerad av Nordic Stroke Society ägde rum i Malmö den 26-28 augusti, 2015. Föreningen som i många år arrangerat nordiska strokekongresser bildades för över 30 år sedan. Denna rapport från årets kongress av Ann-Cathrin Jönsson, docent vid Institutionen för hälsovetenskaper, Lunds universitet, inleds med en beskrivning av bakgrunden till Nordic Stroke Society.
Search for stable hadronising squarks and gluinos with the ATLAS experiment at the LHC
Hitherto unobserved long-lived massive particles with electric and/or colour charge are predicted by a range of theories which extend the Standard Model. In this Letter a search is performed at the ATLAS experiment for slow-moving charged particles produced in proton-proton collisions at 7 TeV centre-of-mass energy at the LHC, using a data-set corresponding to an integrated luminosity of 34 pb(-1)
Dynamics of major histocompatibility complex class II-positive cells in the postischemic brain - influence of levodopa treatment
Background: Cerebral ischemia activates both the innate and the adaptive immune response, the latter being activated within days after the stroke onset and triggered by the recognition of foreign antigens. Methods: In this study we have investigated the phenotype of antigen presenting cells and the levels of associated major histocompatibility complex class II (MHC II) molecules in the postischemi
Robot-assisted laparoscopic surgery for cervical cancer
Cervical cancer is the third most common cancer in women worldwide and the fourth leading cause of cancer death. In Western countries, it is the 10th most common cause of cancer death. Cervical cancer often affects young women (< 40 years) who have not finished childbearing. Robot assistance is the latest development in laparoscopic surgery. There is one robot commercially available for gynecologi
Vitamin D Status at Birth and Future Risk of Attention Deficit/Hyperactivity Disorder (ADHD).
To investigate whether children with Attention Deficit/Hyperactivity Disorder have lower levels of Vitamin D3 at birth than matched controls.