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Granulocyte-stimulating factor and severe aplastic anemia: a survey by the European Group for Blood and Marrow Transplantation (EBMT)

Previous studies suggested a link between the use of G-CSF and increased incidence of myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML) after immunosuppressive therapy (IST) for severe aplastic anemia (SAA). This European survey included 840 patients who received a first-line IST with (43%) or without (57%) G-CSF. The incidences of MDS/AML in patients who did or did not receive G-CSF

Variations in the isotopic composition of molybdenum in freshwater lake systems

Variations in molybdenum isotopic composition, spanning the range of similar to 2.3 parts per thousand in the terms of Mo-97/Mo-95 ratio, have been measured in sediment cores from three lakes in northern Sweden and north-western Russia. These variations have been produced by both isotopically variable input of Mo into the lakes due to Mo isotopic heterogeneity of bedrock in the drainage basins and

Military expenditures in developing countries: a comment on Deger and Sen

This note contains a criticism of an article by Deger and Sen (1983) who discuss the causes of military expenditure in less developed countries. It is argued that their utility function is unsuitably specified and that the conclusions drawn may be called into question. Moreover, it is doubtful whether the concept of a benevolent government that maximizes a single utility function is conducive to a

Nondielectric long-range solvation of polar liquids in cubic symmetry

Long-range solvation properties of strongly coupled dipolar systems simulated using the Ewald and reaction field methods are assessed by using electric fluctuation formulas for a dielectric medium. Some components of the fluctuating electric multipole moments are suppressed, whereas other components are favored as the boundary of the simulation box is approached. An analysis of electrostatic inter

Monitoring for sustainable development : a systemic framework

'Sustainable development' is a widely used, but less practised, complex term. Using the idea of 'Viability Loops' (VL) based on a System Dynamics (SD) approach and considering sustainability as an ideal for development efforts, this paper argues that sustainable development should be considered as an unending process rather than a state. Thus, a systemic framework is proposed to 'monitor' systems

Large eddy simulations of turbulent swirling flows in a dump combustor: a sensitivity study

Large eddy simulations (LES) of confined turbulent swirling flows in a model dump combustor are carried out. The simulations are based on a high-order finite difference method on a Cartesian grid, with the sub-grid scale stress tensor modelled using a scale-similarity model. The aims of this work are to study the physics of the flow and to evaluate the performance of LES method for simulation of t

Integrated Assessment Modeling of Air Pollution in Four European Countries.

The integrated assessment modeling on acid rain has incorporated several related effects and pollutants into a multi-pollutant/multi-effect approach, resulting in complex integrated models and policy assessments. The development and implementation of effects-oriented cost-effective emission reduction strategies in Europe are based on integrated assessment models. The project on national integrated

Phenolic Acid Nanoparticle Formation in Iron-Containing Aqueous Solutions.

This paper presents results which show that the interaction between two phenolic acids, p-coumaric and caffeic acid, with iron results in the formation of meta-stable colloidal nano particles. The particles are characterized with dynamic light scattering and cryo-transmission electron microscopy. The results show that the nanoparticle formation is an important feature of phenolic acids which is li

Robustness of metabolic maps

With the ever increasing amount of genomic data available, the interest for generating biochemical pathways has grown tremendously. So far, mainly complete genomes have been used to reconstruct the biochemical pathways and their associated interactions. However, a large number of low coverage genomes, as well as other sources of partial genomic data, are currently available for many organisms. In

Repeated open application tests with methyldibromoglutaronitrile in dermatitis patients with and without hypersensitivity to methyldibromoglutaronitrile

Background: Contact allergy to and allergic contact dermatitis from methyldibromoglutaronitrile (MDBGN) have been frequently reported since the 1990s. Objective: This study was initiated to help determine the optimal test preparation for MDBGN and to help determine the clinical relevance of such a contact allergy. Method. In 38 patients with positive (32 patients) or doubtful (6 patients) patch-te

Outcomes of coordinated and integrated interventions targeting frail elderly people: a systematic review of randomised controlled trials

The aim of this study was to review randomised controlled trials on integrated and coordinated interventions targeting frail elderly people living in the community, their outcome measurements and their effects on the client, the caregiver and healthcare utilisation. A literature search of PubMed, AgeLine, Cinahl and AMED was carried out with the following inclusion criteria: original article; inte

Molecular theory of field-dependent proton spin-lattice relaxation in tissue

A molecular theory is presented for the field-dependent spin-lattice relaxation time of water in tissue. The theory attributes the large relaxation enhancement observed at low frequencies to intermediary protons in labile groups or internal water molecules that act as relaxation sinks for the bulk water protons. Exchange of intermediary protons not only transfers magnetization to bulk water proton

Non visual haptic audio tools for virtual environments

This paper reports the results of a test involving twelve users of different haptic audio navigational tools for non-visual virtual environments. Analysis of the test results confirms the usefulness of a constant attractive force as well as of haptic fixtures to help users locate objects in a virtual environment. The 3D audio turned out to be less useful due to the design of the environment. Howev

A novel sulfonated dendritic polymer as the acidic component in proton conducting membranes

The present study involves the synthesis of sulfonated poly(3-ethyl-3-(hydroxymethyl)oxetane), sPTMPO, by end-capping the hydroxy-groups in the PTMPO with 1,4-butane sultone. A series of the polymer with different degrees of substitution was investigated. Furthermore, the subsequent use of the sulfonated PTMPO as the acidic component in proton conducting membranes was explored. The membranes were

The structures of human dihydroorotate dehydrogenase with and without inhibitor reveal conformational flexibility in the inhibitor and substrate binding sites.

Inhibitors of dihydroorotate dehydrogenase (DHODH) have been suggested for the treatment of rheumatoid arthritis, psoriasis, autoimmune diseases, Plasmodium, and bacterial and fungal infections. Here we present the structures of N-terminally truncated (residues Met30-Arg396) DHODH in complex with two inhibitors: a brequinar analogue (6) and a novel inhibitor (a fenamic acid derivative) (7), as wel