Interleukin-1 (IL-1)-family cytokines are potent modulators of inflammation, coordinating a vast array of immunological responses across innate and adaptive immune systems. Dysregulated IL-1-family cytokine signaling, however, is involved in a multitude of adverse health effects, such as chronic inflammatory conditions, autoimmune diseases, and cancer. Within the IL-1 family of cytokines, six—IL-1

Defining minimal standards for data collection is key to creating interoperative, searchable genomic and clinical databases. We highlight here the 1+Million Genomes Minimal Dataset for Cancer, encompassing 140 items in 8 domains to foster the collection of cancer data, inform transnational cooperation and advance precision cancer medicine.

In November 2022 the European Commission launched a new regulatory framework proposal for packaging and packaging waste, EU Packaging and Packaging Waste Regulation, which includes mandatory reuse and refill targets of packed food products. With specific focus on perishable liquid food products, such as dairy, plant-based beverages, juices, and nectars, which are currently primarily available in s

This special issue explores the intertwining reconfigurations of labour and welfare in the Global South by bringing together eight empirical studies of different national and transnational contexts and three commentaries. It asks how Global South people and states alike have come to prioritize market logics as guiding principles for welfare systems, moving away from collective risk-pooling towards

One of the major open problems in complexity theory is proving super-logarithmiclower bounds on the depth of circuits (i.e., P⊈NC1). Karchmer et al. (Comput Complex 5(3/4):191–204, 1995) suggested to approach thisproblem by proving that depth complexity behaves “as expected”with respect to the composition of functions f◊g. They showedthat the validity of this conjecture would imply that P⊈NC1.Seve

Conventional dendritic cells (cDC) play key roles in immune induction, but what drives their heterogeneity and functional specialization is still ill-defined. Here we show that cDC-specific deletion of the transcriptional repressor Bcl6 in mice alters the phenotype and transcriptome of cDC1 and cDC2, while their lineage identity is preserved. Bcl6-deficient cDC1 are diminished in the periphery but

Business continuity management (BCM) is an analytic process capable of fostering the resilience of critical societal functions. While previous research on BCM primarily has focused on its applications within individual organizations, today's modern society involves networks of interdependent actors collectively delivering these essential functions to end users. This necessitates an expansion of BC

Cerium doped (Lu,Y)2SiO5 (or LYSO) single crystals have been studied by means of luminescence excitation spectroscopy in the temperature range from 7 up to 300 K. Vacuum ultraviolet excitations in 4.5–8 eV energy range from synchrotron radiation of 1.5 GeV storage ring of MAX IV synchrotron facility. It is shown that both type of Ce3+ emission centers (seven and six coordinated centers) are excite

Radio signals are used broadly as navigation aids, and current and future terrestrial wireless communication systems have properties that make their dual-use for this purpose attractive. Sub-6 GHz carrier frequencies enable widespread coverage for data communication and navigation, but typically offer smaller bandwidths and limited resolution for precise estimation of geometries, particularly in e

We construct a set of Wigner 6j symbols with gluon lines (adjoint representations) in closed form, expressed in terms of similar 6j symbols with quark lines (fundamental representations). Together with these Wigner 6j symbols with quark lines, this gives a set of 6j symbols sufficient for treating QCD color structure for any number of external particles, in or beyond perturbation theory. This faci

Multimorbidity, i.e., two or more non-communicable diseases (NCDs), is an escalating challenge for society. Venous thromboembolism (VTE) is a common cardiovascular disease and it is unknown which multimorbidity clusters associates with VTE. Our aim was to examine the association between different common disease clusters of multimorbidity and VTE. The study is an extended (1997–2015) cross-sectiona

The electronic structure of high-quality van der Waals multiferroic CuCrP2S6 crystals was investigated by applying photoelectron spectroscopy methods in combination with DFT analysis. Using X-ray photoelectron and near-edge X-ray absorption fine structure (NEXAFS) spectroscopy at the Cu L2,3 and Cr L2,3 absorption edges, we determine the charge states of ions in the studied compound. Analyzing the

Background Acute kidney injury (AKI) is a common and severe complication in patients treated at an Intensive Care Unit (ICU). The pathogenesis of AKI has been reported to involve hypoperfusion, diminished oxygenation, systemic inflammation, and damage by increased intracellular iron concentration. Hepcidin, a regulator of iron metabolism, has been shown to be associated with sepsis and septic shoc

In my blog post, I turn to a more technical aspect of the judgment, namely the question of causation. I will untangle the analytical gymnastics that the Court performs regarding this question. I will argue that the reasoning regarding causation is confusing and that it is not clear how specifically the ‘real prospect’ test is applied for finding a breach.

Disasters and crises are increasingly seen as opportunities for transformation of the tourism system at various scales. From a resilience perspective, crises and disasters may act as trigger events for system change, sometimes described as the “disaster-reform hypothesis”. An integrative framework informed by different fields is used to analyse the destination development pathways following the Ka

Understanding the growth dynamics of III-V nanowires is crucial to attaining the atomistic control of nanowire growth required for the fabrication of high-quality devices. In situ studies allow us to monitor the individual processes of the cyclic layer-by-layer growth, which permits us to gain more insight into the growth dynamics than using conventional growth studies. Here, we demonstrate how th

This study examines the first-hand sources of Kemalism to understand how and to what extent the French Revolution inspired the Kemalist elite and influenced Kemalism during the early republican period. In the literature, there is a general perception that the French Revolution and Jacobinism were highly influential on the Kemalists, but this perception mainly depends on broad interpretations witho

Hemosporidian parasite communities are broadly similar in Boulder County, Colorado, between two common songbirds-the Black-capped Chickadee (Poecile atricapillus) and Mountain Chickadee (Poecile gambeli). However, Mountain Chickadees appear more likely to be infected with Plasmodium and potentially experience higher infection burdens with Leucocytozoon in contrast to Black-capped Chickadees. We fo

This paper examines the local exponential stability (LES) of trajectories for nonlinear systems on Riemannian manifolds. We present necessary and sufficient conditions for LES of a trajectory on a Riemannian manifold by analyzing the complete lift of the system along the given trajectory. These conditions are coordinate-free which reveal fundamental relationships between exponential stability and

Klimatförändringar och social rättvisa är två sammanlänkade utmaningar för städer och kommuner. I takt med att miljö- och klimatkriserna förvärras blir behovet av att sammanlänka ekologisk och social hållbarhet alltmer centralt för städers och kommuners omställning. Tidigare separata åtgärder för dessa områden har ofta misslyckats med att tillvarata synergier och hantera motsättningar. Projektet u