Background: Real-world data on starting intravenous (IV) vedolizumab (VDZ) and transitioning to subcutaneous (SC) treatment in inflammatory bowel disease (IBD) are scarce. Aims: To assess treatment outcomes of patients with IBD starting IV VDZ and switching to SC VDZ in routine clinical care. Methods: Adult patients with IBD switching from IV to SC VDZ treatment between 1 March 2020 and 31 Decembe

Groundwater accounting is becoming increasingly important for sustainable societal development. To gain insights into the long-term spatiotemporal changes from 1992 to 2015 regarding groundwater resources in Kumamoto, southern Japan, we analyzed climatological time series, discharge from the groundwater-fed lake (Ezu Lake), and groundwater levels from 94 wells. To explicitly detect temporal change

This thesis addresses different aspects of atoms interacting with strong laser fields. The focus is on population and ionization dynamics occurring on ultrafast timescales, when atoms are subjected to intense extreme ultraviolet or infrared laser light. Different ways of modeling these interactions are considered. Comparisons to experimental results are performed in certain cases, and in other cas

By the Merovingian Period (6–8th century CE) a large variety of dogs and the earliest evidence of dog leashes appear in South Scandinavia. This indicates exchange, breeding and use of new types of dogs in this period. The purpose of this study is to examine the social significance and function of dogs in the Merovingian Period in South Scandinavia based on an analysis of the Nabbero ̈r boat grave By the Merovingian Period (6–8th century CE) a large variety of dogs and the earliest evidence of dog leashes appear in South Scandinavia. This indicates exchange, breeding and use of new types of dogs in this period. The purpose of this study is to examine the social significance and function of dogs in the Merovingian Period in South Scandinavia based on an analysis of the Nabberör boat grave on

Business Process Modeling, Simulation and Design, Third Edition provides students with a comprehensive coverage of a range of analytical tools used to model, analyze, understand, and ultimately design business processes.The new edition of this very successful textbook includes a wide range of approaches such as graphical flowcharting tools, cycle time and capacity analyses, queuing models, discret

High-density lipoproteins (HDLs) are responsible for removing cholesterol from arterial walls, through a process known as reverse cholesterol transport. The main protein in HDL, apolipoprotein A-I (ApoA-I), is essential to this process, and changes in its sequence significantly alter HDL structure and functions. ApoA-I amyloidogenic variants, associated with a particular hereditary degenerative di

Soft materials are usually defined as materials made of mesoscopic entities, often self-organised, sensitive to thermal fluctuations and to weak perturbations. Archetypal examples are colloids, polymers, amphiphiles, liquid crystals, foams. The importance of soft materials in everyday commodity products, as well as in technological applications, is enormous, and controlling or improving their prop

With continuously improving signal-to-noise ratios, a statistically sound analysis of quasi-elastic neutron scattering (QENS) spectra requires to fit increasingly complex models which poses several challenges. Simultaneous fits of the spectra for all recorded values of the momentum transfer become a standard approach. Spectrometers at spallation sources can have a complicated non-Gaussian resoluti

Abstract in GermanDas Boot gilt als ein herausragendesSymbol der nordischen Bronzezeit, dargestellt in Tausendenvon Felsbildern und auf vielen Metallgegenständen in ganzSkandinavien. Paradoxerweise sind direkte Hinweise aufdiese Boote rar, und die Orte, an denen Boote gebaut wurden,bleiben größtenteils schwer fassbar. In diesem Artikel schla-gen wir vor, dass die sogenannten Kochgruben entlang derThe boat stands out as a prominent symbol of the Nordic Bronze Age, depicted at thousands of rock art sites and on several metal objects throughout Scandinavia. Paradoxically, direct evidence of these boats is scarce, and the locations where boats were constructed remain largely elusive. In this paper, we put forth the proposition that many ostensibly mislabelled cooking pits along the coast might

One of the most important challenges for modern society is how to feed the world in a sustainable manner. Agriculture is an essential part of food production, but at the same time it has many negative impacts on the environment, through for example pollution, nutrient leaching, and greenhouse gas emissions, and it is a big driver of biodiversity loss. Organic farming is a farming system that in ma

Cancer presently represents a significant global health challenge, illustrated by the high incidence and mortality rates associated with lung and breast cancer. Technological advances and concerted large-scale initiatives have yielded vast amounts of cancer data to be used for research purposes. The objective of this thesis is to capitalize on the current state of the bioinformatics field to devel

Radical right populist parties have often been treated as “pariahs,” being excluded from coalition politics in parliamentary democracies. We argue that negative rhetoric targeted at radical right populist parties in legislative debates is used by the established parties to distance themselves from such parties and that the incentives to do so depend on the political context. Using sentiment analys

Environmentally friendly InP/ZnSe core/shell quantum dots (QDs) with high absorption coefficients and tunable band gaps have demonstrated great potential for photoelectrochemical (PEC) water splitting. However, the tightly bound excitonic feature by inherent type I band alignment tends to reduce the charge separation efficiency, limiting their PEC performance. Herein, we devised heterovalent In3+

Sweden’s child welfare services are characterised by intra-organisational specialisation and collaboration with Barnahus as a standard procedure in cases of child abuse. This chapter examines what happens with social workers’ risk assessments when they are both filtered internally at different units and in relation to Barnahus and a criminal law-oriented logic. Various organisational tensions are

Treatment with the anti-angiogenic drug bevacizumab in addition to chemotherapy has shown efficacy for breast cancer in some clinical trials, but better biomarkers are needed to optimally select patients for treatment. Here, we present an omics approach where DNA methylation profiles are integrated with gene expression and results from proteomic data in breast cancer patients to predict response t

Background and Purpose: Differentiating idiopathic normal pressure hydrocephalus (iNPH) from neurodegenerative disorders such as progressive supranuclear palsy (PSP), Multiple System Atrophy—parkinsonian type (MSA-P), and vascular dementia (VaD) is challenging due to overlapping clinical and neuroimaging findings. This study assesses if quantitative brain stem and cerebellum metrics can aid in thi