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Background: p21-activated kinase 1 (Pak1) phosphorylates many proteins in both normal and transformed cells. Its ability to phosphorylate and thereby activate the estrogen receptor alpha (ER alpha) potentially limits the effectiveness of antiestrogen treatment in breast cancer. Here we studied associations between Pak1 expression and subcellular localization in tumor cells and tamoxifen resistance

A simple assay was developed to estimate functional mannose-binding lectin (MBL) levels in serum based on the principle of yeast-induced bystander lysis of chicken erythrocytes (ChE). The assay is sensitive to inhibition by ethylene glycol bis-(beta-aminoethyl ether)-N,N,N',N'-tetraacetic acid (EGTA) (which allows alternative pathway activation), ethylene diamine tetraacetic acid (EDTA), mannose,

Filial Children and Ageing Parents is an anthropological study of the politics and practice of intergenerational relations among Chinese Singaporeans. Contrary to idealized notions of solid Chinese/Asian family values, this paper attempts to unfold the strains and challenges of intergenerational family relations in everyday life. In particular, it examines the issue of filial obligations between c

-Glucosidases belong to families 1, 3 and 9 of the glycoside hydrolases and act on cello-oligosaccharides. Family 1 and 3 enzymes are retaining and are reported to have transglycosylation activity, which can be used to produce oligosaccharides and glycoconjugates. Family 3 enzymes are less well characterized than their family 1 homologues and to date only two crystal structures have been solved. H

A detailed study of the positive parity yrast and yrare rotational bands in Rb-77 is presented. Using the reaction Ca-40(Ca-40,3p) and the EUROGAM I spectrometer, gamma gamma gamma coincidences enabled us to follow both bands over a large spin range and to measure many E2 strengths. The moments of inertia and transition quadrupole moments indicate that a more deformed band (epsilon(2) approximate

The status of experimental approach to Sn-100 and Ni-78 is reviewed. Revised single particle energies for neutrons are deduced for the N=Z=50 shell closure and evidence for low lying I-pi=2(+) and 3(-) states is presented. Moderate E2 polarization charges of 0.1 e and 0.6 e are found to reproduce the experimental data when core excitation of Sn-100 is properly accounted for in the shell model. For

An experimental and theoretical study of PdMn bimetallic systems formed on Pd(100) is presented. It is shown that a flat Mn monolayer can be formed at 90 K. A comparison of calculated Mn 3d density-of-states and experimental valence photoemission and x-ray-absorption results suggests that the monolayer is antiferromagnetic, in line with earlier predictions. A similar comparison for the Pd(100)-Mn-

This report contains research summaries of the 17 PhD projects that were active at the Department of Automatic Control in June 1999.

Abstract in Norwegian Målet med denne studien var å utforske hvordan en kunne fortolke ekstatisk spiritualitet i et religionspsykologisk perspektiv, illustrert ved Toronto-vekkelsen. Studien er en kvalitativ studie basert på intervjuer, feltobservasjoner og skrevne dokumenter. Det teoretiske rammeverket er interdisiplinært ved at det er brukt teorier fra egopsykologi, sosialpsykologi, sosiologi, kThe purpose of this dissertation was to study how to interpret ecstatic spirituality, illustrated by the Toronto Blessing, from a religio-psycho¬logical point of view. The study is a qualitative research based on inter¬views, field observations and written documents. The theo¬retical framework is interdisciplinary, using theories from ego-psychology, social psychology, sociology, cultural anthropo

Partial differential equations, describing the consumption of reactants and the formation of products, have been solved numerically for a step change from inert to reactant feed considering different variants of propene oxidation mechanisms. The response features and their dependency on the rate limiting step have been rationalised in terms of conclusions, which can serve as general guidelines for

Popular Abstract in Swedish Alla finansiella modeller bygger på antaganden, approximationer och förenklingar. Syftet med avhandlingen är att undersöka giltigheten och rimligheten i ett antal välkända och populära finansiella och ekonometriska modeller, med en tonvikt på de svenska aktie- och optionsmarknaderna. De ekonomiska och statistiska effekterna av alltför restriktiva modellantaganden undersThis thesis consists of five essays exploring the validity of some extensively used financial models with a focus on the Swedish equity and derivative markets. The essays are of both an empirical and a theoretical nature. In the first paper, The Search for Chaos and Nonlinearities in Swedish Stock Index Returns, an investigation of the presence of nonlinearities in general and chaos in particular

OBJECTIVES: Exposing a hind leg of a rat to vibration induces an injury to the sciatic nerve--a so called conditioning lesion. After such injury induced by vibration the regenerative capacity of the nerve is improved and can be detected as an increased axonal outgrowth from a test crush lesion to the same nerve. The purpose was to study whether the effect of a conditioning lesion induced by vibrat

Human dendritic cells (DCs) are a distinct but heterogeneous lineage of APCs operating as the link between innate and adaptive immune responses, with the function to either maintain,tolerance or trigger immunity. The DC lineage consists of several subpopulations with unique phenotypes; however, their functional characteristics and transcriptional similarities remain largely unknown. To further cha

We apply the Fokker-Planck equation to analyze the stochastic behavior of a 1-micron diameter polystyrene bead trapped in water using an optical tweezer. Due to thermal noise, given enough time, a trapped particle will escape con nement from the trap. However, at biological temperatures, for laser powers of greater than approximately 5 milliwatts at the focus, the mean rst exit time in the lateral