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Effects of Ice Nucleation Protein Repeat Number and Oligomerization Level on Ice Nucleation Activity

Ice nucleation active bacteria have attracted particular attention due to their unique ability to produce specific ice nucleation proteins (INpros), which are the most efficient ice nuclei known as they induce nucleation at temperatures close to 0°C. Our model bacterium Pseudomonas syringae strain R10.79 produced INpros containing 67 tandem repeats, forming the proposed ice-binding surface. To und

Effect of Human Myotubes-Derived Media on Glucose-Stimulated Insulin Secretion

Fasting to postprandial transition requires a tight adjustment of insulin secretion to its demand, so tissue (e.g., skeletal muscle) glucose supply is assured while hypo-/hyperglycemia are prevented. High muscle glucose disposal after meals is pivotal for adapting to increased glycemia and might drive insulin secretion through muscle-released factors (e.g., myokines). We hypothesized that insulin

Photodissociation of aligned CH3I and C6H3F2I molecules probed with time-resolved Coulomb explosion imaging by site-selective extreme ultraviolet ionization

We explore time-resolved Coulomb explosion induced by intense, extreme ultraviolet (XUV) femtosecond pulses from a free-electron laser as a method to image photo-induced molecular dynamics in two molecules, iodomethane and 2,6-difluoroiodobenzene. At an excitation wavelength of 267 nm, the dominant reaction pathway in both molecules is neutral dissociation via cleavage of the carbon-iodine bond. T

Non-convex Rank/Sparsity Regularization and Local Minima

This paper considers the problem of recovering either a low rank matrix or a sparse vector from observations of linear combinations of the vector or matrix elements. Recent methods replace the non-convex regularization with ℓ1 or nuclear norm relaxations. It is well known that this approach recovers near optimal solutions if a so called restricted isometry property (RIP) holds. On the other hand i

Farmland Conservation : Evidence for the effects of interventions in northern and western Europe

This synopsis covers evidence for the effects of conservation interventions for native farmland wildlife. It is restricted to evidence captured on the website www.conservationevidence.com. It includes papers published in the journal Conservation Evidence, evidence summarized on our database and systematic reviews collated by the Collaboration for Environmental Evidence. It is the thrid volume in t

Catching glimpses : the fragment-anthology as a strategy for architectural research

The weaving together of fragments under the heading of a “weak” theme has a long tradition in research. The strategy has, however, not been so popular after the 19th century, even though advocates of a more modern fragmentology can be found, e.g. in Walter Benjamin. For Benjamin, the artefacts truly showed themselves only when the context had disappeared or been forgotten. In this article we would

Experimental and Computational Atomic Spectroscopy for Astrophysics : Oscillator strengths and lifetimes for Mg I, Si I, Si II, Sc I, and Sc II

Precis efter Big Bang fanns endast tre grundämnen: väte, helium och en liten mängd litium. De första stjärnorna föddes i gasmoln som innehöll dessa ämnen. När den första generationen stjärnor i slutet av sina liv exploderade som supernovor spreds de tyngre grundämnena som tillverkats ut i det interstellära mediet. Nästa generations stjärnor bildades från detta berikade medium, och innehöll därför Atomic data such as oscillator strengths and wavelengths are important for astrophysical applications as they have a crucial role in determining abundances of specific elements in a star, a galaxy, or any object emitting radiation in the space. Stars in the Galaxy mostly keep the composition of the interstellar gas from which they were formed, therefore studying stellar abundances helps us underst

Assessment of kallikrein 6 as a cross-sectional and longitudinal biomarker for Alzheimer's disease

Background: Kallikrein 6 (KLK6) is known to be an age-related protease expressed at high levels in the central nervous system. It was previously shown to be involved in proteolysis of extracellular proteins implicated in neurodegenerative diseases such as Alzheimer's disease (AD), prompting validation of KLK6 as a potential biomarker of disease. However, analyses of both plasma and cerebrospinal f

Rates and predictors of attrition among children on antiretroviral therapy in Ethiopia : A prospective cohort study

Introduction Attrition from antiretroviral therapy (ART) programmes is a critical challenge among children receiving care in resource-limited settings. Our objective was to determine the rates and predictors of attrition among children on ART in Ethiopia. Methods Between December 2014 and September 2016, we conducted a prospective cohort study in eight health facilities in Ethiopia. Eligibility cr

What can the State do for you? : Relocation Allowances and Regional Subsidies in Post-War Sweden

It has been suggested that Swedish policy during the early postwar period was strongly directed towards mobility increasing expenditures, most notably relocation allowances, aimed at moving labor from north to south. While this view has dominated the academic discussion on labor market policy there is little direct evidence. We make three claims. First, the relocation allowances have to be evaluat

Interregional Migration, Wages and Labor Market Policy : Essays on the Swedish Model in the Postwar Period

The Swedish model is perceived as a successful framework for combining rapid labor market adjustment with low inequality. Formulated by Gösta Rehn and Rudolf Meidner and implemented from the 1950s, it has been associated with the peak in economic restructuring and interregional migration during the 1960s. However, there is little empirical evidence for this. This thesis consists of an introduction

Ionic liquid interface at an electrode : Simulations of electrochemical properties using an asymmetric restricted primitive model

We use Monte Carlo simulations of a coarse-grained model to investigate structure and electrochemical behaviours at an electrode immersed in room temperature ionic liquids (RTILs). The simple RTIL model, which we denote the asymmetric restricted primitive model (ARPM), is composed of monovalent hard-sphere ions, all of the same size, in which the charge is asymmetrically placed. Not only the hard-

Evaluation of bowel function in healthy children : Untreated constipation is common

Aim: We evaluated bowel function in healthy children with regard to gender and age. Methods: The study was carried out in 2016 at a tertiary children's hospital. Healthy children aged 3.5 years to 15 years who were admitted to the hospital, siblings to patients or offspring of staff members were included. Validated self-report questionnaires and internally developed questions regarding obstructive

Evaluating vacquinol-1 in rats carrying glioblastoma models RG2 and NS1

Glioblastoma multiforme (GBM) is the most common malignant primary brain tumor, and available experimental and routine therapies result in limited survival benefits. A vulnerability of GBM cells to catastrophic vacuolization and cell death, a process termed methuosis, induced by Vacquinol-1 (VQ-1) has been described earlier. In the present study, we investigate the efficacy of VQ-1 treatment in tw

The spectra of harmonic layer potential operators on domains with rotationally symmetric conical points

We study the adjoint of the double layer potential associated with the Laplacian (the adjoint of the Neumann-Poincaré operator), as a map on the boundary surface Γ of a domain in R3 with conical points. The spectrum of this operator directly reflects the well-posedness of related transmission problems across Γ. In particular, if the domain is understood as an inclusion with complex permittivity ε,

New material of scalidophoran worms in Orsten-type preservation from the Cambrian Fortunian Stage of South China

Scalidophoran worms diversified in the Cambrian Fortunian, as indicated by recent reports from this stage, with two described species and two more unnamed forms exclusively from Orsten-type Lagerstätten yielding three-dimensionally phosphatized fossils. Here, we report new material of scalidophoran worms in Orsten-type preservation from the Cambrian Fortunian Xinli section in northern Sichuan Prov