Background: Kallikrein 6 (KLK6) is known to be an age-related protease expressed at high levels in the central nervous system. It was previously shown to be involved in proteolysis of extracellular proteins implicated in neurodegenerative diseases such as Alzheimer's disease (AD), prompting validation of KLK6 as a potential biomarker of disease. However, analyses of both plasma and cerebrospinal f

Introduction Attrition from antiretroviral therapy (ART) programmes is a critical challenge among children receiving care in resource-limited settings. Our objective was to determine the rates and predictors of attrition among children on ART in Ethiopia. Methods Between December 2014 and September 2016, we conducted a prospective cohort study in eight health facilities in Ethiopia. Eligibility cr

It has been suggested that Swedish policy during the early postwar period was strongly directed towards mobility increasing expenditures, most notably relocation allowances, aimed at moving labor from north to south. While this view has dominated the academic discussion on labor market policy there is little direct evidence. We make three claims. First, the relocation allowances have to be evaluat

The Swedish model is perceived as a successful framework for combining rapid labor market adjustment with low inequality. Formulated by Gösta Rehn and Rudolf Meidner and implemented from the 1950s, it has been associated with the peak in economic restructuring and interregional migration during the 1960s. However, there is little empirical evidence for this. This thesis consists of an introduction

We use Monte Carlo simulations of a coarse-grained model to investigate structure and electrochemical behaviours at an electrode immersed in room temperature ionic liquids (RTILs). The simple RTIL model, which we denote the asymmetric restricted primitive model (ARPM), is composed of monovalent hard-sphere ions, all of the same size, in which the charge is asymmetrically placed. Not only the hard-

Aim: We evaluated bowel function in healthy children with regard to gender and age. Methods: The study was carried out in 2016 at a tertiary children's hospital. Healthy children aged 3.5 years to 15 years who were admitted to the hospital, siblings to patients or offspring of staff members were included. Validated self-report questionnaires and internally developed questions regarding obstructive

Glioblastoma multiforme (GBM) is the most common malignant primary brain tumor, and available experimental and routine therapies result in limited survival benefits. A vulnerability of GBM cells to catastrophic vacuolization and cell death, a process termed methuosis, induced by Vacquinol-1 (VQ-1) has been described earlier. In the present study, we investigate the efficacy of VQ-1 treatment in tw

We study the adjoint of the double layer potential associated with the Laplacian (the adjoint of the Neumann-Poincaré operator), as a map on the boundary surface Γ of a domain in R3 with conical points. The spectrum of this operator directly reflects the well-posedness of related transmission problems across Γ. In particular, if the domain is understood as an inclusion with complex permittivity ε,

Scalidophoran worms diversified in the Cambrian Fortunian, as indicated by recent reports from this stage, with two described species and two more unnamed forms exclusively from Orsten-type Lagerstätten yielding three-dimensionally phosphatized fossils. Here, we report new material of scalidophoran worms in Orsten-type preservation from the Cambrian Fortunian Xinli section in northern Sichuan Prov

Lemierres syndrom kännetecknas klassiskt av tonsillit, trombos i vena jugularis interna samt septiska lungembolier. Ofta har patienten också sepsis. Sjukdomen drabbar framför allt yngre personer i åldern 15–25 år.Effektiv antibiotikabehandling kopplad till kirurgisk lokal behandling (source control) över tid är fundamental i handläggningen.Sen diagnos och behandling ökar risken för komplicerat vårThe purpose of this case report and discussion is to heighten the awareness of Lemierres syndrome (postanginal sepsis). Affected patients present in various fields of medicine and an increased incidence of “the forgotten disease” may be expected. Fusobacterium necrophorum is the most common pathogen. The clinical course includes a primary head or neck infection with thrombosis of the internal jugu

A major issue in Irish economic history is the lack of national accounts before the interwar period. This paper constructs new annual estimates of real GDP between 1842 and 1913 based on a novel two-stage econometric approach. Our results show that while living standards approximately tripled in this period, development was uneven with contractions in economic activity not only during the Great FaA major issue in Irish economic history is the lack of national accounts before the interwar period. This paper constructs new annual estimates of real GDP between 1842 and 1913 based on a novel two-stage econometric approach. Our results show that while living standards approximately tripled in this period, development was uneven with contractions in economic activity not only during the Great Fa

In this paper, we present a time-recursive implementation of a recent hyperparameter-free group-sparse estimation technique. This is achieved by reformulating the original method, termed group-SPICE, as a square-root group-LASSO with a suitable regularization level, for which a time-recursive implementation is derived. Using a proximal gradient step for lowering the computational cost, the propose

We consider the over-fitting problem for multinomial probabilistic Latent Semantic Analysis (pLSA) in collaborative filtering, using a regularization approach. For big data applications, the computational complexity is at a premium and we, therefore, consider a maximum a posteriori approach based on conjugate priors that ensure that complexity of each step remains the same as compared to the un-re

Objective: The aim was to evaluate surgical routes for benign hysterectomy in a Swedish population, including abdominal and minimally invasive surgery. Study design: Prospectively collected data from the Swedish National GynOp Registry 2009–2015: 13 806 hysterectomy cases were included: abdominal (AH, n = 7485), vaginal (VH, n = 3767), conventional laparoscopic (LH, n = 1539) and robotically-assis

This article will present and discuss the process of digital co-production and audiences' responses to the full-scale interactive, gestural, visual and musical experience of a Virtual Reality arts play. This was inspired by cist-slab images from the Kivik Grave, which is Sweden's most famous Bronze Age grave. The aim of the VR arts play was to use digital technology to engage users as time-travell

A novel feature extraction method for lowdimensional signal representation is presented. The features are useful for classification of non-stationary multi-component signals with stochastic variation in amplitudes and time-frequency locations. Using a penalty function to suppress the Wigner-Ville ambiguity function auto-terms, the proposed feature set is based on the cross-term doppler- and lag pr

Purpose: The objective was to assess the reliability level of mini-plate fixation used in fracture mandibles in order to evaluate the structure stability in both convalescence and healing periods. Methods: In the convalescence period, the failure scenario is measured by the relative displacement between two fracture surfaces which should not exceed an acceptable value in order to obtain a good sta

The present numerical study aims to assess the performance of an Eulerian Stochastic Field (ESF) model in simulating spray flames produced by three fuel injectors with different nozzle diameters of 100 μm, 180 μm and 363 μm. A comparison to the measurements shows that although the simulated ignition delay times are consistently overestimated, the relative differences remain below 28%. Furthermore,