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Characterization of the complete genomes of Camelus dromedarius papillomavirus types 1 and 2

Camel papillomatosis has been described previously, but the genome of the suspected papillomavirus (PV) has not been identified. An outbreak of papillomatosis occurred in a dromedary farm of 55 animals in Sudan during August 2009. The disease was only present in young animals aged about 3-7 months, of which 44% (11/25) were affected with lesions, mainly on the lips and lower jaw. This study report

Skin toxicity and quality of life in patients with metastatic colorectal cancer during first-line panitumumab plus FOLFIRI treatment in a single-arm phase II study

Background: Integument-related toxicities are common during epidermal growth factor receptor (EGFR)-targeted therapy. Panitumumab is a fully human monoclonal antibody targeting the EGFR that significantly improves progression-free survival when added to chemotherapy in patients with metastatic colorectal cancer who have wild-type (WT) KRAS tumours. Primary efficacy and tolerability results from a

Validity and reliability of a Swedish version of the Relationship Assessment Scale (RAS): a pilot study

BACKGROUND: There is a need for a short and easily administered scale, in the Swedish language, for assessing partner relationships in the health care of persons with cardiac disease. PURPOSE: To establish the reliability and validity of the Swedish version of the Relationship Assessment Scale (RAS). DESIGN: The present pilot study has a methodological design. FINDINGS: Content validity has been t

Low elastin content of carotid plaques is associated with increased risk of ipsilateral stroke.

Atherosclerotic plaques with a low content of connective tissue proteins are believed to have an increased risk of rupture and to give rise to clinical events. The aim of the present study was to investigate if the content of elastin, collagen and of the matrix metalloproteinase (MMP) -1, -3, -9 and -12 in plaques removed at surgery can be associated with the occurrence of ipsilateral symptoms.

Continuous DOPA synthesis from a single AAV: dosing and efficacy in models of Parkinson's disease.

We used a single adeno-associated viral (AAV) vector co-expressing tyrosine hydroxylase (TH) and GTP cyclohydrolase 1 (GCH1) to investigate the relationship between vector dose, and the magnitude and rate of recovery in hemi-parkinsonian rats. Intrastriatal injections of >1E10 genomic copies (gc) of TH-GCH1 vector resulted in complete recovery in drug-naïve behavior tests. Lower vector dose gave p

Impact of dual temperature profile in dilute acid hydrolysis of spruce for ethanol production.

ABSTRACT: BACKGROUND: The two-step dilute acid hydrolysis (DAH) of softwood is costly in energy demands and capital costs. However, it has the advantage that hydrolysis and subsequent removal of hemicellulose-derived sugars can be carried out under conditions of low severity, resulting in a reduction in the level of sugar degradation products during the more severe subsequent steps of cellulose hy

Extensive Gamma-ray Spectroscopy of Normally and Superdeformed Structures in 61Cu

A largely extended experimental knowledge of the Cu-61(29)32 nucleus has been obtained from three experiments. Excited states in Cu-61 were produced via the fusion-evaporation reaction Si-28(Ar-36, 3p)Cu-61. In addition to the Ge array GAMMASPHERE, neutron and charged-particle detectors placed around the target position were used for high-performance particle spectroscopy. The constructed level sc

Coordinates and 2MASS and OGLE identifications for all stars in Arp's 1965 finding chart for Baade's Window

Aims. We seek to provide 2MASS and OGLE identifications and coordinates for all stars in the finding chart published by Arp (1965, ApJ, 141, 43). This chart covers the low extinction area around NGC 6522, also known as Baade's window, at coordinates (l, b) = (1.02, -3.92). Methods. A cross correlation, using numerical techniques, was performed between a scan of the original finding chart from Arp

Magnetic phases of one-dimensional lattices with 2-4 fermions per site

We study the spectral and magnetic properties of one-dimensional lattices filled with 2-4 fermions (with spin-1/2) per lattice site. We use a generalized Hubbard model that takes into account all the interactions on a lattice site, and solve the many-particle problem by exact diagonalization. We find an intriguing magnetic phase diagram which includes ferromagnetism, spin-1 Heisenberg antiferromag

Jewish Thought, Utopia and Revolution

In respons to the grim realities of the present world, Jewish thought has not tended to retreat into eschatological fantasy, but rather to project utopian visions precisely onto the present moment, envisioning redemptions that are concrete, immanent, and necessarily political in nature. The purpose of this book is to contribute to the deeper understanding of the relationship between Jewish thought

Drugs prescribed by general practitioners according to age, gender and socioeconomic status after adjustment for multimorbidity level

Background: Age, gender and socioeconomic status have been shown to be associated with the use of prescription drugs, even after adjustment for multimorbidity. General practitioners have a holistic and patient-centred perspective and our hypothesis is that this may reflect on the prescription of drugs. In Sweden the patient may seek secondary care without a letter of referral and the liability of

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History Reborn inFree Competition: The Czech and Slovak Post-communist Transitions and Their Dominant Historical Narratives Two of the four historical narratives presented here, the Czech national-liberal narrative and the Slovak national-European narrative, imbue Czech and Slovak history with national and democratic meaning, by using history to legitimize future aims in these areas. The two rema

Streptococci and Platelets - A Study of Host-Pathogen Interaction Dynamics

Invasive infections remains one of the leading causes of death due to infections over the world, and efficient treatment remains elusive. One of the major causes of sepsis and other invasive infections is pathogenic streptococci that cause a wide range of clinical manifestations in humans. Group A and group G streptococci have both been shown to cause both infections of milder ranges as well as se

Fibrin binds to collagen and provides a bridge for alpha V beta 3 integrin-dependent contraction of collagen gels

The functional significance of fibrin deposits typically seen in inflammatory lesions, carcinomas and in healing wounds is not fully understood. In the present study, we demonstrate that fibrinogen/fibrin specifically bound to native Col I (collagen type I) and used the Col I fibre network as a base to provide a functional interface matrix that connects cells to the Col I fibres through alpha V be

Development of a novel macrostructured cathode for large-area neutron detectors based on the B-10-containing solid converter

We present a novel design for a macrostructured cathode that can be coated with a thin layer of the B-10 solid converter and mounted to replace the Boron-lined flat parallel plates of a proportional counter used for slow neutron detection. The proposed design consists of a 3D regular pattern exhibiting millimeter deep grooves with an opening angle of alpha = 45 degrees, which could be created in t