Background. Orthotopic cardiac xenotransplantation has seen substantial advancement in the last years and the initiation of a clinical pilot study is close. However, donor organ overgrowth has been a major hurdle for preclinical experiments, resulting in loss of function and the decease of the recipient. A better understanding of the pathogenesis of organ overgrowth after xenotransplantation is ne

Deep eutectic solvents (DESs) are an emerging class of modern, often “green” solvents with unique properties. Recently, a deep eutectic system based on amphiphilic surfactant N-alkyl-N,N-dimethyl-3-ammonio-1-propanesulfonate (C12 & C14 sulfobetaine) and (1S)-(+)-10-camphor-sulfonic acid in the molar ratio 1:1.5 has been reported. Nanostructuring can be expected in this DES due to the nature of

We investigate whether pure entangled states can be associated to a measurement basis in which all vectors are local unitary transformations of the original state. We prove that for bipartite states with a local dimension that is either 2, 4, or 8, every state corresponds to a basis. Via numerics, we strongly evidence the same conclusion for two qutrits and three qubits also. However, for some sta

Searches for the exclusive decays of Higgs and Z bosons into a vector quarkonium state and a photon are performed in the μ+μ-γ final state with a proton–proton collision data sample corresponding to an integrated luminosity of 139 fb - 1 collected at s=13 TeV with the ATLAS detector at the CERN Large Hadron Collider. The observed data are compatible with the expected backgrounds. The 95% confidenc

Fluctuation measurements are important sources of information on the mechanism of particle production at LHC energies. This article reports the first experimental results on third-order cumulants of the net-proton distributions in Pb–Pb collisions at a center-of-mass energy sNN=5.02 TeV recorded by the ALICE detector. The results on the second-order cumulants of net-proton distributions at sNN=2.7

Background: We investigated all-cause and epilepsy-related mortality in patients operated with resective epilepsy surgery and in non-operated patients with drug-resistant epilepsy. Our hypothesis was that patients who proceed to surgery have lower mortality over time compared with non-operated patients. Method: Data from 1329 adults and children from the Swedish National Epilepsy Surgery Register

Hereditary ataxia is a heterogeneous group of complex neurological disorders. Next-generation sequencing methods have become a great help in clinical diagnostics, but it may remain challenging to determine if a genetic variant is the cause of the patient’s disease. We compiled a consecutive single-center series of 87 patients from 76 families with progressive ataxia of known or unknown etiology. W

Background: Patients with bacteraemia caused by gram-positive bacteria are at risk for infective endocarditis (IE). Because IE needs long antibiotic treatment and sometimes heart valve surgery, it is very important to identify patients with IE. Objectives: In this narrative review we present and discuss how to determine which investigations to detect IE that are needed in individual patients with

Rent control measures are typically in place to assist low-income households and decrease segregation. Yet, there is little empirical research on the social impact of such policies and specifically the role of how rent-controlled apartments are allocated. This study analyzes the income-distributional effects of rent control with a novel dataset that includes characteristics of those who received r

Optically pure lactic acid (LA) is needed in PLA (poly-lactic acid) production to build a crystalline structure with a higher melting point of the biopolymer than that of the racemic mixture. Lignocellulosic biomass can be used as raw material for LA production, in a non-food biorefinery concept. In the present study, genetically engineered P. acidilactici ZP26 was cultivated in a simultaneous sac

This study sheds light upon how memes about rioting in present-day Belfast are read by their audiences. As such, it answers to a distinct research gap in the meme studies literature, which has mostly shied away from in-depth engagements with audiences, favouring instead the intertwined concepts ‘imagined audience’ and the ideological ‘directionality’ of memes. Drawing on semi-structured interviews

Background and purpose — Antibiotic-loaded bone cement (ALBC) and systemic antibiotic prophylaxis (SAP) have been used to reduce periprosthetic joint infection (PJI) rates. We investigated the use of ALBC and SAP in primary total knee arthroplasty (TKA). Patients and methods — This observational study is based on 2,971,357 primary TKAs reported in 2010–2020 to national/regional joint arthroplasty

The transverse-momentum (pT) spectra of K ∗(892)0 and ϕ(1020) measured with the ALICE detector up to pT = 16 GeV/c in the rapidity range - 1.2 < y< 0.3 , in p–Pb collisions at the center-of-mass energy per nucleon–nucleon collision sNN=5.02 TeV are presented as a function of charged particle multiplicity and rapidity. The measured pT distributions show a dependence on both multiplicity and rapidit

STUDY QUESTION: Has cumulative live birth rate (CLBR) improved over time and which factors are associated with such an improvement? SUMMARY ANSWER: During an 11-year period, 2007-2017, CLBR per oocyte aspiration increased significantly, from 27.0% to 36.3%, in parallel with an increase in blastocyst transfer and cryopreservation by vitrification. WHAT IS KNOWN ALREADY: While it has been shown that

Cancer is one of the leading causes of death globally. Novel therapeutics is urgently needed to advance treatment, especially for generalized disease where current treatment options have a poor prognosis. In particular, targeted therapy that can address genetic changes would be of great value. RNA interference is an evolutionary conserved gene regulatory mechanism that can be used by introducing e

We present state-of-the-art high-precision theory predictions for the dominant angular coefficients parametrizing the spin-correlations in the production and decay of a W-boson produced at transverse momentum larger than 30 GeV. The computation at NNLO QCD and NLO EW accuracy are combined to obtain differential distributions in the W-boson transverse momentum and rapidity. The found results show u

A search for a WZ resonance, in the fully leptonic final state (electrons or muons), is performed using 139 fb - 1 of data collected at a centre-of-mass energy of 13 TeV by the ATLAS detector at the Large Hadron Collider. The results are interpreted in terms of a singly charged Higgs boson of the Georgi–Machacek model, produced by WZ fusion, and of a Heavy Vector Triplet, with the resonance produc

Background Familial adenomatous polyposis (FAP) is a rare inherited syndrome that predisposes the patient to cancer. Treatment of FAP-related ampullary lesions is challenging and the role of endoscopic papillectomy has not been elucidated. We retrospectively analyzed the outcomes of endoscopic papillectomy in matched cohorts of FAPrelated and sporadic ampullary lesions (SALs). Methods This retrosp