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Human glandular kallikrein 2 (hK2) in prostate cancer: Clinical and Methodological studies

Popular Abstract in Swedish Prostata cancer är en av de vanligast förekommande cancerformerna hos män i västvärlden och den vanligaste förekommande hos män i Sverige. Årligen diagnosticeras i Sverige ungefär 6000 fall och mer än 2000 avlider. Drygt 70% av alla som drabbas är äldre än 70 år medan endast ett fåtal är yngre än 50 år. Sjukdomen ter sig mycket olika hos olika patienter. En del som drabHuman glandular kallikrein 2 (hK2) is a predominantly prostate produced protein with many similarities to prostate-specific antigen (PSA). Just like for PSA elevated levels of hK2 can be found in men with protate cancer. We created an assay where hK2 in serum could reliably and with negligible cross-reactivity with PSA, be measured down to 0.030 ng/mL. The assay measured free hK2 and hK2 complexe

Modelling parkinsonian akinesia and dyskinesia in dopamine depleted rodents

Popular Abstract in Swedish Parkinsons sjukdom är en av de vanligaste neurologiska sjukdomarna i västvärlden. Vad som orsakar sjukdomen är fortfarande okänt men det betyder sannolikt att det är många faktorer som samverkar för att leda fram till sjukdomen. De mest framträdande symptomen i Parkinsons sjukdom är stelhet, oförmåga att initiera rörelser (s.k. akinesi), balanssvårigheter och tremor (daAnimal models of Parkinson’s disease and L-DOPA-induced dyskinesia are essential to explore pathophysiological hypotheses and to test new treatment options. There are many different animal models of Parkinson's disease, which differ greatly with respect to species, mechanisms of nigral cell death, and extent of dopamine-dependent motor deficits. My work has been performed in rats and mice with uni

Perspective from a semiotical perspective

No abstract but see Conclusion: In this article I have described a kind of relationship to the subject which may aptly be called a perspective while distinguishing it from other similar phenomena (such as “aspect”): it is a case in which an object is conceived as being constant, while the modes of access which a subject may have to it varies. I have also singled out some different kinds of perspe

Transfer and adsorption of surfactants to an expanding oil water interface during membrane emulsification

uses a microporous membrane operated in cross-flow. The continuous phase is pumped along the membrane and sweeps away dispersed phase droplets forming from pore openings as shown in Figure 1. The key feature of the membrane emulsification process, which sets it apart from conventional emulsification technologies, is that the size distribution of the resulting droplets is primarily governed by the

Laminin G Domains, their Receptors, and Activation of Intracellular Pathways

Popular Abstract in Swedish Extracellulär matrix är namnet på det molekylära nätverk vilket finns mellan celler i flercelliga organismer. Det består av socker och proteiner organiserade i olika vävnadsspecifika nätverk. Två huvudformer finns, basalmembran och interstitiell extracellulär matrix. Basalmembran ligger som en tunn filt under epitel- och endotelceller, runt fettväv, muskler och periferaBasement membranes are sheet like structures underlying epithelial, endothelial, adipocytes, muscle and peripheral nerve cells. Laminins are an important family of basement membrane proteins implicated in various biological functions through their interactions with cell surface receptors. Laminins are trimers composed of a, b and g chains. Integrins, dystroglycan and other transmembrane glycoprote

A musician's narrative

In addition to three personal narratives by musicians from different continents, the author has invited scholars from diverse spezialisations and locations to comment on different sections of the book, opening up a critical dialogue with voices from different parts of the globe. Musical categorization, identity, values, aesthetic evaluation, creativity, curriculum, assessment and teacher education

Investigation of Kinetically Labile Supramolecu-lar System Addressing Substrate Selectivity in the Catalytic Epoxidations of Olefins

Popular Abstract in Swedish Inom kemin kan uppbyggnaden av molekylära aggregat styras genom att använda sig av kovalenta bindningar eller genom att utnyttja svaga växelverkningar. Den moderna kemin baseras på många års grundforskning på reaktionsförlopp där bildningen av en kovalent bindning stått i fokus vilket har gjort det möjligt att förutsäga utfallet av en sådan reaktion. Däremot är det betyThis thesis is devoted to the development and investigation of a supramolecular system used to catalyze Jacobsen-Katsuki epoxidations with the aim to attain substrate selectivity without product inhibition. The supramolecular catalyst is composed of two well-defined entities or units: a catalytic and a receptor. The keyword for the design was flexibility. The interactions foming the supramolecula