Centrality, Central Location and Central Place – the branching of the discourseThis article is an investigation into two central Swedish concepts in the study of landscapes and urbanization, namely central location (“centralort”) and central place (“centralplats”). The travel of these concepts is followed within geography, history and archaeology, from the 1930s and 40s of Germany to the study of

This randomized trial compared the effects of imagery rescripting against in vivo exposure administered separately during a single session with 27 socially anxious individuals. Previous research shows that imagery rescripting is a promising treatment technique for various disorders including social anxiety, although imagery rescripting and exposure for social anxiety have not yet been compared. So

OBJECTIVE: To characterize the systemic phenotype of primary Sjögren's syndrome at diagnosis by analysing the EULAR-SS disease activity index (ESSDAI) scores.METHODS: The Sjögren Big Data Consortium is an international, multicentre registry based on worldwide data-sharing cooperative merging of pre-existing databases from leading centres in clinical research in Sjögren's syndrome from the five con

This article examines the ways in which independent creative collectives disrupt, or counteract, the official narratives and top-down branding of a designated creative city in Indonesia. This article explores the everyday lived practices of creativity of individuals within three creative collectives in Bandung: Tobucil & Klabs, Kineruku and Omuniuum. Based on field research conducted between 2

This package facilitates working with probability distributions by means of Monte-Carlo methods, in a way that allows for propagation of probability distributions through functions. This is useful for, e.g., nonlinear uncertainty propagation. A variable or parameter might be associated with uncertainty if it is measured or otherwise estimated from data. We provide two core types to represent proba

Four hundred eighty-three specimens of the genus Parmelia collected in Belarus were examined. Four species, P. ernstiae, P. saxatilis, P. serrana and P. sulcata, were identified in this study. The distribution of these species in Belarus is reviewed. Parmelia saxatilis appeared to be an extremely rare species in Belarus known from a single locality. Parmelia ernstiae is reported from Belarus for t

Standard Model events with prompt, isolated, same-charge high-pT leptons are rare, and therefore events with such final states provide a powerful signature towards new discoveries. This thesis presents two searches for doubly charged Higgs bosons decaying into same-charge lepton pairs using proton–proton collision data recorded by the ATLAS detector at the LHC. Observation of doubly charged Higgs

The Finnish-born, Swedish-Jewish composer and music critic Moses Pergament belonged to the first generation of Swedish modernists. Pergament’s Jewish and Swedish identity, as well as his modern aesthetic ideals, made him an outsider during the interwar period. The fact that Pergament, as a Jew, called himself a Swedish composer was seen as provocative and placed him in a cultural battlefield. The

Our contemporary time is haunted by fabricated stories or so called “fake news”. Some of them are threatening the long-term work to promote health carried out by bodies, such as the WHO. The origin of human immunodeficiency virus (HIV) being a contamination and a mutation originating from primates is well-documented. Despite this well documented fact, alternative narratives are often being heard o

Telomeres, the DNA-protein structures capping the ends of linear chromosomes, are important for regulating replicative senescence and maintaining genome stability. Telomeres consist of G-rich repetitive sequences that end in a G-rich single-stranded (ss) 3′ overhang, which is vital for telomere function. It is largely unknown how the 3′ overhang is protected against exonucleases. In budding yeast,

PRDM9 is a PR domain containing protein which trimethylates histone 3 on lysine 4 and 36. Its normal expression is restricted to germ cells and attenuation of its activity results in altered meiotic gene transcription, impairment of double-stranded breaks and pairing between homologous chromosomes. There is growing evidence for a role of aberrant expression of PRDM9 in oncogenesis and genome insta

Platelets are megakaryocyte-derived cellular fragments lacking a nucleus and are classically known for their crucial role in supporting hemostasis. Besides their hemostatic function, it is becoming increasingly clear that platelets are much more diverse and that they are capable of a wide range of immune-sensing functions. This chapter will focus on these non-hemostatic immunological aspects, espe

Melanoma tumors are driven by a hyperactivated mitogen-activated protein kinase (MAPK) signalling pathway, and therefore can generally be classified by mutations within the B-Raf proto-oncogene (BRAF), RAS family of proto-oncogenes, neurofibromin 1 (NF1), or other genes. At the transcriptional level, several genetic classifications of melanoma have converged on the distinction between melanogenesi