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On the (lack of) correspondence between syntactic clauses and intonational phrases

This paper discusses the syntax–prosody mapping at the clause-level, or the potential absence thereof. In particular, the paper reexamines the validity and the necessity of the clause-level mapping constraint, MatchClause, proposed in Match Theory (Selkirk 2009, 2011). First, it will be shown, based on the results of previous empirical studies, that data from embedded clauses in Japanese do not pr

Climate change effects on marine species across trophic levels

Climate change and anthropogenic activities are producing a range of new selection pressures, both abiotic and biotic, on marine organisms. While there are numerous studies that have investigated the response of individual marine organisms to climate change, few studies have focused on differences in organismal responses across trophic levels. Such trophic differences in response to climate change

Use of health self-management platform features: The case of a specialist ehealth app

Specialist digital platforms are enabling unprecedented opportunities for changing routines in the context of health self-management. The emergence of app features for self-management of chronic conditions is transforming the use of digital platforms. In this respect, many developers struggle to understand how diverse users use different features for health self-management. The purpose of this pap

The two-domain elevator-type mechanism of zinc-transporting ZIP proteins

Zinc is essential for all organisms and yet detrimental at elevated levels. Hence, homeostasis of this metal is tightly regulated. The Zrt/Irt-like proteins (ZIPs) represent the only zinc importers in metazoans. Mutations in human ZIPs cause serious disorders, but the mechanism by which ZIPs transfer zinc remains elusive. Hitherto, structural information is only available for a model member, BbZIP

Investigating stable oxygen and carbon isotopic variability in speleothem records over the last millennium using multiple isotope-enabled climate models

The incorporation of water isotopologues into the hydrology of general circulation models (GCMs) facilitates the comparison between modeled and measured proxy data in paleoclimate archives. However, the variability and drivers of measured and modeled water isotopologues, as well as the diversity of their representation in different models, are not well constrained. Improving our understanding of t

Obesity-associated Blunted Subcutaneous Adipose Tissue Blood Flow After Meal Improves After Bariatric Surgery

Context: Glucose-dependent insulinotropic peptide (GIP) and meal ingestion increase subcutaneous adipose tissue (SAT) perfusion in healthy individuals. The effects of GIP and a meal on visceral adipose tissue (VAT) perfusion are unclear. Objective: Our aim was to investigate the effects of meal and GIP on VAT and SAT perfusion in obese individuals with type 2 diabetes mellitus (T2DM) before and af

Organo-Metal Halide Scintillator with Weak Thermal Quenching Up to 200 °C

The prominent thermal quenching (TQ) effect of organic-inorganic metal halides limits their applications for lighting and imaging. Herein, we report an organo-metal halide scintillator (TTPhP)2MnCl4(TTPhP+= tetraphenylphosphonium cation), which exhibits a weak TQ effect up to 200 °C under ultraviolet-visible light (efficiency loss of 5.5%) and X-ray radiation (efficiency loss of 37%). The light yi

Trends of Dispensed Opioids in Catalonia, Spain, 2007–19 : A Population-Based Cohort Study of Over 5 Million Individuals

Objective: To characterize the trend of opioid use (number of users, dispensations and oral morphine milligram equivalents) in Catalonia (Spain). Design, setting, and participants: This population-based cohort study included all individuals aged 18 years or older, registered in the Information System for Research in Primary Care (SIDIAP), which covers >75% of the population in Catalonia, Spain, fr