Sökresultat

Filtyp

Din sökning på "*" gav 529856 sökträffar

A case of facial cellulitis and necrotizing lymphadenitis due to cowpox virus infection

We describe a patient with facial cellulitis/erysipelas due to cowpox virus inoculation in the respiratory epithelium of the nose. A cytopathic agent was isolated in cell culture, and the diagnosis of cowpox was confirmed by electron microscopy and polymerase chain reaction. The most likely source of infection was exposure to the family cats. In addition to the severe edematous cellulitis of the f

Methods to study phosphorylation and activation of the hormone-sensitive adipocyte phosphodiesterase type 3B in rat adipocytes

Cyclic nucleotide phosphodiesterases (PDEs) include a large group of structurally related enzymes that are responsible for the hydrolysis of cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP). These enzymes belong to at least nine related gene families (PDEs 1–9) (1–5), which differ in their primary structures, affinities for cAMP and cGMP, responses to specific effect

Concentration of plastic strains in steel liners due to concrete cracks in the containment wall

A substantial part of nuclear containments in US and Europe are designed with an outer bearing concrete structure and an inner sealing consisting of a tight-welded steel liner. The liner constitutes the ultimate leak-barrier, which prevents leakage at high internal pressure loads. The purpose of this paper is to show which influence a through-wall concrete crack may have on the strain level in the

Simulations of time series of atmospherically distorted wavefronts

A comparatively simple way to generate time series of atmospherically distorted wave fronts is described and tested. Temporal power spectra of Zernike aberrations, extracted from the time series, agree very well with theoretical predictions. A method for generation of longer time series is also shown to give results in accordance with theory, except for the lowest temporal frequencies modeled. A w

Design, synthesis, and biological evaluation of combretastatin nitrogen-containing derivatives as inhibitors of tubulin assembly and vascular disrupting agents

A series of analogs with nitro or serinamide substituents at the C-2'-, C-5'-, or C-C-position of the combretastatin A-4 (CA4) B-ring was synthesized and evaluated for cytotoxic effects against heart endothelioma cells, blood flow reduction to tumors in SCID mice, and as inhibitors of tubulin polymerization. The synthesis of these analogs typically featured a Wittig reaction between a suitably fun

Characteristics of gel electrolytes formed by self-aggregating comb-shaped polyethers with end-functionalised side chains

Gel electrolytes based on comb-shaped polyethers have been prepared and characterised. The comb-shaped polyethers consisted of poly(ethylene oxide) (PEO) or poly(ethylene oxide-co-propylene oxide) (PEOPO) side chains tethered to styrenic backbone polymers. All the polyether side chains were terminated by hydrocarbon (C-16) chain ends. Polymer gel electrolytes were prepared by adding 10-70 wt.% of

Supply chain security - mitigation measures and a logistics multi-layered framework

Statistics show that large amounts of goods moved in distribution chains incur the risk for being stolen, counterfeited or contaminated. At the same time terror threats for smuggling weapons of mass destructions, or intentionally altering products, are pushing governments to require higher security from logistics and transport operators. As a consequence, supply chain managers have to face the dif

Lack of neuroprotection by heat shock protein 70 overexpression in a mouse model of global cerebral ischemia.

Heat shock protein 70 (Hsp70) is induced in cells by a variety of stress conditions, is known to be cytoprotective, and has been proposed to be neuroprotective during brain ischemia. A recently developed mouse model of 12-min global cerebral ischemia by bilateral common carotid artery occlusion with artificial ventilation and bilateral monitoring of regional cerebral blood flow by laser Doppler wa

DNA gel particles: Particle preparation and release characteristics

Aqueous mixtures of oppositely charged polyelectrolytes undergo associative phase separation, resulting in coacervation, gelation, or precipitation. This phenomenon has been exploited here to form DNA gel particles by interfacial diffusion. We report the formation of DNA gel particles by mixing solutions of DNA (either single-stranded (ssDNA) or double-stranded (dsDNA)) with solutions of cationic

Ca2+-binding and Ca2+-independent respiratory NADH and NADPH dehydrogenases of Arabidopsis thaliana.

Type II NAD(P)H:quinone oxidoreductases are single polypeptide proteins widespread in the living world. They bypass the first site of respiratory energy conservation, constituted by the type I NADH dehydrogenases. To investigate substrate specificities and Ca2+ binding properties of seven predicted type II NAD(P)H dehydrogenases of Arabidopsis thaliana we have produced them as T7-tagged fusion pro

An attempt at distinguishing subgroups of women with anorexia nervosa and bulimia nervosa by means of the Defense Mechanism Technique modified (DMTm) and the Eating Disorder Inventory (EDI).

In an attempt to identify diagnostically meaningful subgroups in a group of sixty women 18–34 years of age, 19 of them having a DSM-IV diagnosis of anorexia nervosa and 41 of bulimia nervosa, a hierarchical cluster analysis was performed on their data obtained from the Defense Mechanism Technique modified (DMTm) and the Eating Disorder Inventory (EDI). Variables also taken into account in the clus

Transnational Tendencies in Multinational Enterprises

Purpose – The purpose of this paper is to present a synthesis of transnational tendencies in multinational enterprises (MNEs), to theoretically analyse the result and to study whether managers in MNEs have experienced the predicted tendencies. Design/methodology/approach – The synthesis is based on an extensive literature review which is analysed by transaction cost economics. Identified tendenc

The R620W C/T polymorphism of the gene PTPN22 is associated with SLE independently of the association of PDCD1

The gene PTPN22 is located on chromosome 1p13 and encodes a protein tyrosine phosphatase called the lymphoid-specific phosphatase (Lyp). Lyp is expressed in lymphocytes, where it physically associates through its proline-rich motif ( called P1) with the SH3 domain of the protein tyrosine kinase Csk, an important suppressor of the Src family of kinases Lck and Fyn, which mediate TCR signaling. Ther

Evaluating a nonlinear asset pricing model on international data

The paper analyses the ability of a non-linear asset pricing model suggested by Dittmar [Dittmar, R.F., 2002. Non-linear pricing kernels, kurtosis preference, and the cross-section of equity returns. Journal of Finance 57, 369–403] to explain the returns on international value and growth portfolios. For comparison we use competing pricing models such as the ICAPM, the exchange rate risk augmented

Morphological and functional characterization of a rat vaginal smooth muscle sphincter

The aim of the present study was to gain information about adrenergic-, cholinergic- and nonadrenergic, non-cholinergic (NANC)- transmitter systems/mediators in the rat vagina, and to characterize its smooth muscles functionally. Tissue sections from vagina of Sprague Dawley rats were immunolabelled with antibodies against protein gene product 9.5 (PGP), synaptophysin (Syn), tyrosine hydroxylase (

Knowledge Links in High-Technology Industries: Markets, Networks, or Milieu? The Case of the Vienna Biotechnology Cluster

In recent years, the innovation process in biotechnology has become a subject of major interest to scholars from different disciplines. Despite an ever growing body of work, the nature of knowledge links and their particular geography remain a highly disputed issue. The purpose of this paper is to shed some light on this topic. We will develop a model of knowledge interactions distinguishing betwe

Revascularisation of renal artery stenosis caused by fibromuscular dysplasia: effects on blood pressure during 7-year follow-up are influenced by duration of hypertension and branch artery stenosis

Fibromuscular dysplasia (FMD) mainly affects renal arteries. Percutaneous transluminal renal angioplasty (PTRA) and surgery are effective treatments, but longtime follow-up is lacking. Retrospective follow-up for 7.0 +/- 4.7 years of 69 consecutive patients ( age 44 +/- 13 years) treated for hypertension due to FMD, 59 patients underwent PTRA and eight patients surgery. In two patients no PTRA was

Preliminary observations of sperm storage in Adalia bipunctata (Coleoptera : Coccinellidae): sperm size and number

Sperm storage in Adalia bipunctata (L.) (Coleoptera, Coccinellidae) was examined and compared between diapausing and non-diapausing females. We observed that non-diapausing females store on average 13,688 (+/-722, S.E.) sperm in their spermatheca and that every female examined had sperm in storage (n = 16). In contrast, most diapausing females had empty spermatheca and only two had sperm in storag