Four new polyhydroxy pregnane glycosides, named volubilosides G−K (3, 5–7), along with three known secondary metabolites, dregeoside Da1 (1), dregeoside Ka1 (2), and volubiloside E (4) were isolated from the twigs and leaves of Dregea volubilis (DV). The chemical structures of these compounds (1–7) were elucidated using spectroscopic techniques (1D and 2D NMR and HR-ESI-MS analyses) and compared w

Collisionless dark matter only (DMO) structure formation simulations predict that dark matter (DM) haloes are prolate in their centres and triaxial towards their outskirts. The addition of gas condensation transforms the central DM shape to be rounder and more oblate. It is not clear, however, whether such shape transformations occur in 'ultra-faint' dwarfs, which have extremely low baryon fractio

Visibility in smoke is a key aspect in terms of safe egress in various fire related situations. Due to the hazardous nature of fire induced smoke, it is hard to study human behaviour under such conditions, but recent development within the field of virtual reality (VR) has enabled exposure to many different hazardous conditions while remaining relatively safe. However, to obtain valid results from

Detta självständiga arbete i musikpedagogik undersöker elevers kollektiva kompositionsprocesser inom ramen för skolans musikundervisning. Undersökningen har skett med utgångspunkt i ett genomfört kompositionsprojekt med grupper av gymnasieelever vid ett musikestetiskt program i Sverige, vilket ägde rum i samband med den verksamhetsförlagda delen av 2022 års höst-termin vid Musikhögskolan i Malmö.This independent degree project in music pedagogy investigates students collective processes of composition as a part of their music-education in school. The investigation draws upon a composition project with groups of high school students at a Swedish aesthetical high school program, which was carried out in connection with the teaching placement in autumn term 2022 at Malmö Academy of Music. Th

In this study, a three-dimensional computational fluid dynamics (CFD) model is employed to investigate the hydrodynamic and combustion characteristics of biomass particles in an industrial-scale circulating fluidized bed (CFB) furnace. The CFD model considered here is based on the Eulerian-Lagrangian framework, the multi-phase particle-in-cell (MP-PIC) collision model, the coarse grain method (CGM

Dynamical response of water exposed to x-rays is of utmost importance in a wealth of science areas. We exposed isolated water isotopologues to short x-ray pulses from a free-electron laser and detected momenta of all produced ions in coincidence. By combining experimental results and theoretical modeling, we identify significant structural dynamics with characteristic isotope effects in H2O2+, D2O

Three examples of nuclear structure effects in fission dynamics are discussed: (i) The appearance of a super-short symmetric mode in the fission of nuclei around 264Fm leading to two double-magic 132Sn, (ii) Fission of some super-heavy elements where the heavy cluster is focused around double-magic 208Pb, and (iii) A saw-tooth distribution in angular momenta versus the fission fragment mass in the

Melanin pigments play a critical role in physiological processes and shaping animal behaviour. Fossil melanin is a unique resource for understanding the functional evolution of melanin but the impact of fossilisation on molecular signatures for eumelanin and, especially, phaeomelanin is not fully understood. Here we present a model for the chemical taphonomy of fossil eumelanin and phaeomelanin ba

Teamwork is considered something positive. While there is much research on teamwork in healthcare, research on teamwork in home care nursing is limited. As the need for home care nursing is likely to increase in the future, it is of great interest to investigate the circumstances associated with the implementation of teamwork in home care nursing. The present study compares the results from a larg

Linking clinical multi-omics with mechanistic studies may improve the understanding of rare cancers. We leverage two precision oncology programs to investigate rhabdomyosarcoma with FUS/EWSR1-TFCP2 fusions, an orphan malignancy without effective therapies. All tumors exhibit outlier ALK expression, partly accompanied by intragenic deletions and aberrant splicing resulting in ALK variants that are

I en tid av omfattande psykisk ohälsa och ständigt påtryckande sociala normer gällande kroppsideal är tonårstiden en kritisk period. De rådande diskussionerna som talar om att tonåringars psykiska hälsa förvärras är alarmerande och tyder på ett växande behov av att studera detta närmre. Denna studie ämnade att undersöka om det bland 13–14 åringar har skett en förändring gällande psykisk ohälsa ochIn a time of extensive mental health problems and constantly pressing social norms regarding body ideals, adolescence is a critical period. The current discussion concerning the worsening of adolescents' mental health is alarming and indicates a growing need to study this more closely. This study aimed to examine whether there has been a change among 13-14-year-olds concerning mental health an

Rheumatoid arthritis (RA) involves several classes of pathogenic autoantibodies, some of which react with type-II collagen (COL2) in articular cartilage. We previously described a subset of COL2 antibodies targeting the F4 epitope (ERGLKGHRGFT) that could be regulatory. Here, using phage display, we developed recombinant antibodies against this epitope and examined the underlying mechanism of acti

Introduction: Until now, the mechanism underlying the impact of topping on hormone regulation in tobacco plants remains unclear, and most studies investigating the hormone signaling pathways in plants rely on genes or transcriptional pathways. Methods: This study examines the regulatory mechanisms of hormones in the roots and leaves of tobacco plants with and without topping at the protein level.

Introduction: The ancient city of Tel Megiddo in the Jezreel Valley (Israel), which lasted from the Neolithic to the Iron Age, has been continuously excavated since 1903 and is now recognized as a World Heritage Site. The site features multiple ruins in various areas, including temples and stables, alongside modern constructions, and public access is allowed in designated areas. The site has been

Detta examensarbete är en undersökning av förstärkning av klassisk gitarr. Ett antal olika metoder tas i bruk: en litteraturstudie ger en första orientering som kompletteras med ett flertal intervjuer med professionella gitarrister och ljudtekniker. Författarens egen erfarenhet aktiveras genom en rekonstruktion av tidigare upplevelser av att arbeta med inspelning och förstärkning av instrumentet. This thesis is an inquiry concerned with classical guitar amplification. A number of different methods are applied: a survey of literature on the topic is complemented with a series of interviews. The experience of the author is addressed through a reconstruction of earlier experience and finally, a series of tests are carried out together with a fellow guitar student and a teacher in studio techn