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Background: Therapies that could further prevent the development of heart failure (HF) and other cardiovascular and metabolic events in patients with recent myocardial infarction (MI) represent a large and unmet medical need. Methods: DAPA-MI is a multicenter, parallel-group, registry-based, randomized, double-blind, placebo-controlled phase 3 trial in patients without known diabetes or establishe

Identity cues in animal calls are essential for conspecific vocal individual recognition. Some acoustically active species mainly show reliable identity cues in their vocalizations because of variation in anatomy and life history. Long and strenuous-to-produce vocalizations may be particularly effective for showing identity cues because sustaining such calls may reveal individual anatomical differ

Functional disruption of the medial temporal lobe-dependent networks is thought to underlie episodic memory deficits in aging and Alzheimer's disease. Previous studies revealed that the anterior medial temporal lobe is more vulnerable to pathological and neurodegenerative processes in Alzheimer's disease. In contrast, cognitive and structural imaging literature indicates posterior, as opposed to a

Background: Techniques for autofluorescence have been introduced to visualize the parathyroid glands during surgery and to reduce hypoparathyroidism after thyroidectomy. Methods: This parallel multicentre RCT investigated the use of Fluobeam® LX to visualize the parathyroid glands by autofluorescence during total thyroidectomy compared with no use. There was no restriction on the indication for su

The displacement of an electroactive monitoring agent, i.e., polyamidoamine dendrimers encapsulated gold nanoparticles (PAMAM-Au) upon the presence of a target antibody via acoustic streaming has been studied. Acoustic streaming has been used to improve the mass transfer and reduce the sample incubation rate, thus this study investigated its ability in enhancing the PAMAM-Au displacement efficienc

We report on phase and strain changes in Ti1-xAlxN (0 ≤ x ≤ 0.61) coatings on cutting tools during turning recorded in operando by high-energy x-ray diffractometry. Orthogonal cutting of AISI 4140 steel was performed with cutting speeds of 360–370 m/min. Four positions along the tool rake face were investigated as a function of time in cut. Formation of γ-Fe in the chip reveals that the temperatur

As #MeToo activists took their testimonies of sexual harm outside the legal arena to seek justice, the #MeToo movement has commonly been framed as pitting informal justice-seeking against formal law. This article draws on interviews with Swedish #MeToo activists and focuses on their experiences of justice seeking. It asks the key question: what does justice look like for #MeToo participants? I dem

PURPOSE: The primary care physician's traditional patient contacts are challenged by the rapidly accelerating digital transformation. In a quantitative survey analysis based on the theory of planned behavior, we found high behavioral intention to use telemedicine among Swedish primary care physicians, but low reported use. The aim of this study was to further examine the physicians' experiences re

Rendered imagery is presented to us daily. Special effects in movies, video games, scientific visualizations, and marketing catalogs all often rely on images generated through computer graphics. However, with all the possibilities that rendering offers come also a plethora of challenges. This thesis proposes novel ways of evaluating the visual errors caused when some of those challenges are not co

This article aims at illuminating the role of Swedish and Norwegian municipalities as legal actors in multi-level governance. The research questionis threefold: What is the role of Swedish and Norwegian municipalities as legal actors in relation to the European level? How do these roles affect local autonomy at the national level? What is the impact of the different affiliations at the European le

Collaboration between academia and practice is crucial for addressing complex societal challenges and generating new knowledge. However, bridging the perceived gap between these two domains has proven challenging due to differences in language, expectations, and time horizons. In this article, we question the usefulness of framing these differences as a gap and explores alternative approaches to f

Delirium is a serious and common condition in the intensive care unit (ICU), which affects 30-50 % of the patients and is associated with increased mortality and morbidity in the context of long-term outcomes. No evidence-based treatment for delirium exists, and currently, delirium is mainly treated pharmacologically with haloperidol, a typical antipsychotic agent. The “Agents Intervening against

It is vital to consider acoustic scattering when using geometrical acoustic simulation techniques, such as ray tracing. However, there are few methods for modelling scattering, and most rely on strong assumptions of uniformity on the distribution of scattered energy. In this paper, a model for directional scattering in ray tracers is presented. The model is based on an idealized model of a 1D scat

Room acoustic simulations are an important tool, both for design of spaces with satisfactory acoustics and for use in virtual reality experiences. Auralization of acoustic simulations are becoming more and more important in the context of Virtual and Augmented reality (VR and AR respectively), as the technology is used more and more in healthcare, culture and research. In this work, ray tracing si

Traditionally, psychophysical data is modelled by fitting individual curves to each participant’s data and then by statistical analysis of the extracted parameters. A now viable alternative to this traditional two-stage approach is Bayesian hierarchical modelling (BHM). BHM allows for modelling all of the data and all of the parameters in one-step rather than two. Here, BHM is used to analyse the

The emergence of complementary and community currencies (CCCs) at a global and local scale manifests the normative innovation that characterizes these initiatives. Based on three case studies of CCCs in the Basque Country (the Ekhi, the Eusko and the Txantxi) the present paper explores the normative order of the CCCs and their processes of institutionalization through tactics of legal convergence.