In Alzheimer’s disease, reconfiguration and deterioration of tissue microstructure occur before substantial degeneration become evident. We explored the diffusion properties of both water, a ubiquitous marker measured by diffusion MRI, and N-acetyl-aspartate, a neuronal metabolite probed by diffusion-weighted magnetic resonance spectroscopy, for investigating cortical microstructural changes downs

Formation of amyloid-β (Aβ) fibrils is a central pathogenic feature of Alzheimer's disease. Cell-secreted extracellular vesicles (EVs) have been suggested as disease modulators, although their exact roles and relations to Aβ pathology remain unclear. We combined kinetics assays and biophysical analyses to explore how small (

En ambitiös politik och effektiva styrmedel behövs för en snabb klimatomställning av samhället. Det finns en stor palett av möjliga styrmedel och olika styrmedel fungerar olika bra beroende på vilka hinder för omställningen de är tänkta att hantera. Men även om det i stort är känt vad som behöver göras, vilka styrmedel som finns tillgängliga och hur de bäst kan användas är en annan fråga hur dessa

We present combined theoretical and experimental work investigating the angle-resolved phases of the photoionization process driven by a two-color field consisting of an attosecond pulse train and an infrared pulse in an ensemble of randomly oriented molecules. We derive a general form for the two-color photoelectron (and time-delay) angular distribution valid also in the case of chiral molecules

Introduction: Osteoarthritis (OA) affects over 500 million people worldwide. OA patients are symptomatically treated, and current therapies exhibit marginal efficacy and frequently carry safety-risks associated with chronic use. No disease-modifying therapies have been approved to date leaving surgical joint replacement as a last resort. To enable effective patient care and successful drug develop

Given the increasing severity of the climate crisis and, with it, rising climate anxiety, it is imperative to understand what climate anxiety is, how it functions, and how people can cope with it constructively. Nevertheless, research has often mixed different conceptualizations and operationalizations of climate anxiety, yielding sometimes seemingly contradictory findings. This study contributes

Recent years have seen a rise in extreme heat event (EHE)-related deaths in India. However, the impact of specific temperature thresholds on health risks remains understudied. Using Distributed Lag Non-Linear Models (DLNM), we explored the link between EHEs, defined by various temperature thresholds, and mortality risk in Ahmedabad, India, from 2002 to 2018, considering a 21-day lag. We observed a

The PID controller is the by far most frequently employed type of controller. As you read, billions of digitally implemented PID controllers are running, shaping the dynamic behavior of anything from the fan speed in your laptop to safety-critical components in nuclear power plants. Given the abundance of commissioned PID controllers, it is surprisingly hard to find a single source that provides a

Human physiology is the study of how organisms, organ systems, and individual organs function under normal circumstances. As a consequence of its paramount importance to medicine, physiology has been studied since ancient times, but the models studied in this book follow the tradition of modern physiology pioneered by Claude Bernard in the mid 1800s.The focus of the book lies on how dynamical mech

UNLABELLED: Studies investigating the immunogenicity of additional COVID-19 vaccine doses in immunosuppressed patients with inflammatory rheumatic diseases (IRD) are still limited. The objective was to explore the antibody response including response to omicron virus subvariants (sBA.1 and sBS.2) after third and fourth COVID-19 vaccine doses in Swedish IRD patients treated with immunomodulating dr

The multifunctionality of forest systems calls for appropriately complex modelling approaches to capture social and ecosystem dynamics. Using a social-ecological systems framework, we review the functionality of 31 existing agent-based models applied to managed forests. Several applications include advanced cognitive and emotional decision-making, crucial for understanding complex sustainability c

Natural flood management is emerging as a viable way to leverage ecological services to manage flooding. Stakeholders are progressively positioning natural flood management at the scale of river catchments to encourage a move beyond localised and opportunistic actions towards more strategic and cost-effective flood risk management responses. This reflects a broader turn towards nature-based soluti

This paper explores the link between income, and wealth inequality and the ecological footprint in France, Netherlands, United States, and United Kingdom from 1962 to 2021. Based on theoretical considerations, we allow the relationship to vary over time. Our analysis provides some support for income inequality influencing ecological footprints, specifically through carbon emissions. Yet, we do notThis paper explores the link between income, and wealth inequality and the ecological footprint in France, Netherlands, United States, and United Kingdom from 1962 to 2021. Based on theoretical considerations, we allow the relationship to vary over time. Our analysis provides some support for income inequality influencing ecological footprints, specifically through carbon emissions. Yet, we do not

Denna text visar att det offentliga rummet fyller många viktiga funktioner, och är en viktig demokratisk fråga. Olika människor har olika stort behov av de resurser som det offentliga rummet har att erbjuda, samtidigt som möjligheten till mobilitet ocksåvarierar. En större ensidighet hos offentliga platser minskar den grad av tillgänglighet som dessa platser kan erbjuda. Om det däremot finns förut

Background: Alzheimer's disease (AD) causes progressive decline of cognition and function. There is a lack of systematic literature reviews on prognostic and predictive factors in its early clinical stages (eAD), i.e., mild cognitive impairment due to AD and mild AD dementia. Objective: To identify prognostic factors affecting eAD progression and predictive factors for treatment efficacy and safet

Regular device-scale DNA waves for high DNA concentrations and flow velocities have been shown to emerge in quadratic micropillar arrays with potentially strong relevance for a wide range of microfluidic applications. Hexagonal arrays constitute another geometry that is especially relevant for the microfluidic pulsed-field separation of DNA. Here, we report on the differences at the micro and macr