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Neighborhood deprivation and coronary heart disease in patients with bipolar disorder

The aim was to study the potential effect of neighborhood deprivation on incident and fatal coronary heart disease (CHD) in patients with bipolar disorder. This was a nationwide cohort study which included all adults aged 30 years or older with bipolar disorder (n = 61,114) in Sweden (1997–2017). The association between neighborhood deprivation and the outcomes was explored using Cox regression an

A tunable physiomimetic stretch system evaluated with precision cut lung slices and recellularized human lung scaffolds

Breathing exposes lung cells to continual mechanical stimuli, which is part of the microenvironmental signals directing cellular functions together with the extracellular matrix (ECM). Therefore, developing systems that incorporate both stimuli is urgent to fully understand cell behavior. This study aims to introduce a novel in vitro culture methodology combining a cyclic stretch that simulates in

Cancer risk in severe alpha-1-antitrypsin deficiency

Background Severe alpha-1-antitrypsin deficiency (AATD), phenotype PiZZ, is a risk factor for pulmonary emphysema and liver disease, but its effect on cancer risk is unknown. Our aim was to evaluate the risk and the risk factors for incident cancer in PiZZ individuals compared with the general population with known smoking habits. Methods A longitudinal study of PiZZ individuals (n=1595) from the

Standard Model estimate of K+ →π+4e branching ratio

The branching ratio of the K+→π+e+e-e+e- (K+→π+4e) decay is calculated at leading order in the Standard Model. The dominance of the neutral-pion pole determines the overall branching ratio to be B(K+→π+4e)=B(K+→π+π0)B(π0→4e)≈7.0(3)×10-6. The significance of this contribution is very much concentrated in the context of the whole available phase space, throughout most of which the one-photon-exchang

The Phenomenology of Semiosis : Approaches to the Gap between the Encyclopaedia and the Porphyrian Tree Spanned by Sedimentation

When putting semiotics and phenomenology in juxtaposition, the first task necessarily is to find out what a study of meaning, conceiving of itself as an empirical science, has to do with a philosophical school, the business of which it is to secure the epistemological foundations of all the sciences (broadly understood). Our answer, in short (but we will go at some length to show it), is that sinc

Milk Formula Enriched with Sodium Butyrate Influences Small Intestine Contractility in Neonatal Pigs

Butyrate, a by-product of gut bacteria fermentation as well as the digestion of fat in mother’s milk, exerts a wide spectrum of beneficial effects in the gastrointestinal tissues. The present study aimed to determine the effects of sodium butyrate on small intestine contractility in neonatal piglets. Piglets were fed milk formula alone (group C) or milk formula supplemented with sodium butyrate (g

Phylogenetic Characterization of HIV-1 Sub-Subtype A1 in Karachi, Pakistan

(1) Background: HIV-1 sub-subtype A1 is common in parts of Africa, Russia, former Soviet Union countries, and Eastern Europe. In Pakistan, sub-subtype A1 is the predominant HIV-1 subtype. Preliminary evidence suggests that distinct strains of HIV-1 sub-subtype A1 are circulating in Pakistan; however, an in-depth molecular phylogenetic characterization of HIV-1 sub-subtype A1 strains in Pakistan ha

Association of Cerebrovascular and Alzheimer Disease Biomarkers With Cholinergic White Matter Degeneration in Cognitively Unimpaired Individuals

BACKGROUND AND OBJECTIVES: Several pathologic processes might contribute to the degeneration of the cholinergic system in aging. We aimed to determine the contribution of amyloid, tau, and cerebrovascular biomarkers toward the degeneration of cholinergic white matter (WM) projections in cognitively unimpaired individuals. METHODS: The contribution of amyloid and tau pathology was assessed through

Reference shape effects on Fourier transform holography

Soft-x-ray holography which utilizes an optics mask fabricated in direct contact with the sample, is a widely applied x-ray microscopy method, in particular, for investigating magnetic samples. The optics mask splits the x-ray beam into a reference wave and a wave to illuminate the sample. The reconstruction quality in such a Fourier-transform holography experiment depends primarily on the charact

Current best estimates of beam quality correction factors for reference dosimetry of clinical proton beams

Objective. To review the currently available data on beam quality correction factors, kQ, for ionization chambers in clinical proton beams and derive their current best estimates for the updated recommendations of the IAEA TRS-398 Code of Practice. Approach. The reviewed data come from 20 publications from which kQ values can be derived either directly from calorimeter measurements, indirectly fro

Historical roots of the dual-earner model: Women’s labour force participation in Sweden, 1870–1960

Today, Sweden has one of the highest female labour force participation rates in the developed world, but how deep are the roots of women’s involvement in gainful employment? In this article, I present new estimates of women’s labour force participation rate between 1870 and 1960, the time when the country shifted from a predominantly agrarian economy to an industrial and services-based society. Th

Immigrant Film Co-Operatives in Sweden - The Most Typical Avant-Garde

An account for three production nodes for immigrant film workers in Sweden, Kaleidoscope, Tensta Filmförening and Cineco, as well as an analysis of some of their films.The subtitle of this essay echoes the title of David E. James’s book The Most Typical Avant-Garde, which makes the claim that the various minor cinemas of Los Angeles (amateur, immigrant, artists’ etc.) constitute the most distinctive avant-garde “on behalf of cultural practices that are commonly supposed not to even have existed”. The heterogeneous Swedish avant-garde scene has definitely been co

Graphop mean-field limits and synchronization for the stochastic Kuramoto model

Models of coupled oscillator networks play an important role in describing collective synchronization dynamics in biological and technological systems. The Kuramoto model describes oscillator's phase evolution and explains the transition from incoherent to coherent oscillations under simplifying assumptions, including all-to-all coupling with uniform strength. Real world networks, however, often d

Pollinatörers exponering för växtskyddsmedel via pollen, nektar och luft i jordbrukslandskapet

Syftet med projekt, AirBeeSafe, var att öka kunskapen om bin och andra pollinerande insekters exponering för olika växtskyddsmedel i odlingslandskapet. Projektet utfördes i ett samarbete mellan SLU Centrum för kemiska bekämpningsmedel i miljön (CKB) och Biologiska institutionen, Lunds universitet, samt lantbrukare och biodlare. Finansiering gavs av Naturvårdsverket och det strategiska forskningsom

KinePose: A temporally optimized inverse kinematics technique for 6DOF human pose estimation with biomechanical constraints

Computer vision/deep learning-based 3D human pose estimation methods aim to localize human joints from images and videos. Pose representation is normally limited to 3D joint positional/translational degrees of freedom (3DOFs), however, a further three rotational DOFs (6DOFs) are required for many potential biomechanical applications. Positional DOFs are insufficient to analytically solve for joint

Neuroendocrine Prostate Cancer: FDG-PET and Targeted Molecular Imaging

Purpose/Objective(s): Over 30% of advanced prostate cancers harbor a predominance of neuroendocrine prostate cancer (NEPC) differentiation. Fluorodeoxyglucose (FDG) positron emission tomography (PET) has numerous limitations in prostate adenocarcinoma (PCa-adeno), however there is no data that exists outside of isolated single person case reports to assess the utility of PET to restage and monitor

Exercise training for adult kidney transplant recipients

Objectives: This is a protocol for a Cochrane Review (intervention). The objectives are as follows:. This review aims:. To assess the benefits and harms of regular physical activity interventions in adult kidney transplant recipients when compared with any other or no intervention. To determine whether benefits and harms vary in absolute or relative terms dependent on specific characteristics of t

Tract-based white matter hyperintensity patterns in patients with systemic lupus erythematosus using an unsupervised machine learning approach

Currently, little is known about the spatial distribution of white matter hyperintensities (WMH) in the brain of patients with Systemic Lupus erythematosus (SLE). Previous lesion markers, such as number and volume, ignore the strategic location of WMH. The goal of this work was to develop a fully-automated method to identify predominant patterns of WMH across WM tracts based on cluster analysis. A