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D-lactide is the precursor of poly(D-lactide) (PDLA) or stereo-complex with poly(L-lactide) (PLLA). Lignocellulosic biomass provides the essential feedstock option to synthesize D-lactic acid and D-lactide. The residual sugars in D-lactic acid fermentation broth significantly blocks the D-lactide synthesis. This study showed a simultaneous and rate-coordinated conversion of lignocellulose derived

To train well-performing generalizing neural networks, sufficiently large and diverse datasets are needed. Collecting data while adhering to privacy legislation becomes increasingly difficult and annotating these large datasets is both a resource-heavy and time-consuming task. An approach to overcome these difficulties is to use synthetic data since it is inherently scalable and can be automatical

Forced-choice response format is often considered superior to standard Likert format for controlling social desirability in personality inventories. We performed simulations and found that the trait information based on the two formats converges when the number of items is high and forced-choice items are mixed with regard to positively and negatively keyed items. Given that forced-choice items ex

The immune microenvironment of non-small cell lung cancer (NSCLC) is heterogeneous, which impedes the prediction of response to immune checkpoint inhibitors. We have mapped the expression of 49 proteins to spatial immune niches in 33 NSCLC tumors and report key differences in phenotype and function associated with the spatial context of immune infiltration. Tumor-infiltrating leukocytes (TIL), ide

Objectives: The risk of cardiovascular disease is associated with the echo intensity of carotid plaques in ultrasound images and their cardiac cycle-induced intensity variations. In this study, we aimed to 1) explore the underlying origin of echo intensity variations by using simulations and 2) evaluate the association between the two-dimensional (2D) spatial distribution of these echo intensity v

With the risk of climate breakdown, pressure is increasing for all sectors of the economy to break with fossil fuel dependence and reduce greenhouse gas emissions. In this context, the chemical industry requires more focused attention as it uses more fossil-fuel based energy than any other industry and the production of chemicals is associated with very large emissions. Beyond the climate crisis,

Reconfigurable transistors are an emerging device technology adding new functionalities while lowering the circuit architecture complexity. However, most investigations focus on digital applications. Here, we demonstrate a single vertical nanowire ferroelectric tunnel field-effect transistor (ferro-TFET) that can modulate an input signal with diverse modes including signal transmission, phase shif

There is still quite an unknown and unexploited manuscript of the popular medieval French allegorical poem The Romance of the Rose in Stockholm which is curated in the National Library of Sweden under the number Vu 39. This article has as a goal to give the first information and hypothesis we have about it: the origins of this manuscript which is a version of the XVth Century, a description of its

Background: Energy citizenship has emerged as a concept which attempts to capture the new role envisaged for urban citizens as engaged and active in the energy transition. However, exactly how to successfully engage energy citizens requires more research and this article aims to contribute to this knowledge gap. The article presents a new methodology, ‘Walking with Energy’, which seeks to (re)conn

Video which is part of Halla Steinunn Stefánsdóttir's improvisation to the graphic score 'strengur' (Stefánsdóttir, 2019). Released as part of the 'strengur' album, on the Carrier Records label in 2022.

Abstrakt Antalet vårdplatser per invånare i Sverige har minskat de senaste 20 åren. Akutmottagningarna har fått en ökad belastning. Sjuksköterskornas arbetsuppgifter är många och av olika karaktär, allt från att ta hand om enklare symtom till plötslig död. Arbetet kan vara kroppsligt tung och psykiskt påfrestande. Akutmottagningarna har hög personalomsättning och sänkta kompetenskrav vid nyanställAbstract The number of care places per resident in Sweden has decreased in the last 20 years. A consequence of this has been that the emergency department have had an increased work load. The tasks of an emergency room nurse are stimulating as well as challenging. Multiple tasks of various nature ranging from addressing simple symptoms to acute and sudden death. The work may be physically hard

Both C-N and C-C bond formation reactions are fundamental part of synthetic chemistry and have been widely studied for the past several decades and will most likely continue to do so in the future. In this project, I report a base catalyzed transition metal-free C-N and C-C bond formation reactions from abundant and green substrates with sustainable chemistry in mind. Previous methods uses either

Cancer stem cells are a population of slow-cycling cells within the tumour bulk, with self-renewal capacity that attracts interest as a therapeutic target. In highly heterogeneous tumours, like pancreatic ductal adenocarcinoma (PDAC) however, the characterisation of cancer stem cells has led to controversial results due to the lack of consensus on specific markers. Here we investigated the charact

Buffer management for biopharmaceutical purification processes include buffer preparation, storage of buffers and restocking the buffers when needed. This is usually performed manually by the operators for small scale operations. However, buffer management can become a bottleneck when running integrated continuous purification processes for prolonged times, even at small scale. To address this iss

The use of disposable and reusable packaging is a hot topic in policy and practice, but different studies have come to different conclusions on when each packaging type is the more sustainable alternative. The purpose of this paper is to map and review scientific literature that compares disposable and reusable packaging for food, beverages and e-commerce from a sustainability perspective. The met

Acute respiratory distress syndrome (ARDS), an inflammatory condition with high mortality rates, is common in severe COVID-19, whose risk is reduced by metformin rather than other anti-diabetic medications. Detecting of inflammasome assembly in post-mortem COVID-19 lungs, we asked whether and how metformin inhibits inflammasome activation while exerting its anti-inflammatory effect. We show that m

The life expectancy for pancreatic cancer patients has seen no substantial changes in the last 40 years as very few and mostly just palliative treatments are available. As the five years survival rate remains around 5%, the identification of novel pharmacological targets and development of new therapeutic strategies are urgently needed. Here we demonstrate that inhibition of the G protein-coupled