cGMP interactors play a role in several pathologies and may be targets for cGMP analog-based drugs, but the success of targeting depends on the biochemical stereospecificity between the cGMP-analog and the interactor. The stereospecificity between general cGMP analogs—or such that are selectivity-modified to obtain, for example, inhibitory actions on a specific target, like the cGMP-dependent prot

Denna avhandling undersöker vardagen på två dagliga verksamheter inom psykiatrin i Köpenhamns kommun. Mer specifikt fokuserar avhandlingen patienternas kommunikation och beteenden samt den stigmatisering de upplever från omvärlden. Det empiriska materialet bygger på tre års deltagande observationer. De stadsdelar som de två verksamheterna låg i befann sig i var sin ände av kommunens socioekonomiskThis dissertation looks into everyday life at two day-care centres of community psychiatry in the municipality of Copenhagen. More specifically, it is about the patients' communication and behaviour, and about the stigmatization fromthe outer world they experience. The empirical material is based on three years of participant observation. The two daycare centres and their districts were situated i

Activatable fluorescent probes have been successfully used as molecular tools for biomedical research in the last decades. Fluorescent probes allow the detection of molecular events, providing an extraordinary platform for protein and cellular research. Nevertheless, most of the fluorescent probes reported are susceptible to interferences from endogenous fluorescence (background signal) and limite

In the diagnostic work-up of a newborn infant with a metabolic crisis, lethal multiorgan failure on day six of life, and increased excretion of 3-methylglutaconic acid, we found using whole genome sequencing a homozygous SERAC1 mutation indicating MEGDHEL syndrome (3-methylglutaconic aciduria with deafness-dystonia, hepatopathy, encephalopathy, and Leigh-like syndrome). The SERAC1 protein is locat

Background: Circulating soluble urokinase plasminogen activator receptor (suPAR) is a marker of inflammation with prognostic value for elevated risk of morbidity and mortality. It has not yet been shown how the inflammatory process induced by cardiac surgery affects suPAR concentrations postoperatively Methods: In a prospective observational study, plasma suPAR levels were measured in 30 patients

The 1998 Agreement in Northern Ireland has often been portrayed as a textbook example of agonistic peace allowing parties to continue conflict in a political, adversarial manner post accord. Here, I investigate the institutional and dialogical reality of this claim by scrutinising agonistic aspects of interaction occurring in the Northern Ireland Assembly. Specifically, I analyse a video recording

An alternative surgical technique with closure of the uterine artery at its origin, known as lateral approach prior to TLH, has been proposed and it may offer important benefits to both patients and surgeons. Our objectives were to review the current literature regarding surgical outcomes between lateral and conventional approach in relation to TLH. We followed the ‘PRISMA’ guidelines and conducte

The 2011 Great East Japan Earthquake on March 11, 2011 triggered not only giant tsunami waves, but also caused significant land subsidence followed by land rise in the Sendai Coastal Plain areas. These impacts resulted in severe damages to the coastal infrastructure and induced coastal morphology changes along Japan's northeast coast. It was observed that the maximum downward deformation in the Se

Dokument har en central roll i det sociala arbetets vardag. När ord och siffror skrivs ner och därmed materialiseras går de att hänvisa till, inte bara för sitt innehåll utan också som dokument med en auktoritet i sin egen rätt. Socialarbetaren skapar mening genom att arbetsvardagen regisseras utifrån dokumenten.

Seawater intrusion (SWI) is one of the most important phenomena which occurs in shorelines and islands and affects groundwater storage in the region. This study aims to investigate how far seawater has intruded in a coastal area and what is its extent variation. The results can lead to different management plans. To achieve these goals, a geoelectrical method is applied in the coastal aquifer of C

We investigate the performance of linear consensus algorithms subject to a scaling of the underlying network size. Specifically, we model networked systems with nth order integrator dynamics over families of undirected, weighted graphs with bounded nodal degrees. In such networks, the algebraic connectivity affects convergence rates, sensitivity, and, for high-order consensus [n ≥ 3), stability pr

We study the problem of distributed consensus in networks where the local agents have high-order (n ≥ 3) integrator dynamics, and where all feedback is localized in that each agent has a bounded number of neighbors. We prove that no consensus algorithm based on relative differences between states of neighboring agents can then achieve consensus in networks of any size. That is, while a given algor

In this paper, we study fundamental performance limitations of distributed feedback control in large-scale networked dynamical systems. Specifically, we address the question of whether dynamic feedback controllers perform better than static (memoryless) ones when subject to locality constraints. We consider distributed linear consensus and vehicular formation control problems modeled over toric la

Hörförståelse är en central färdighet i moderna språk som kan vara utmanande att utveckla för eleven. Syftet med denna del är att innehållet ska inspirera till kollegiala reflektioner och diskussioner kring hur eleverna utvecklar hörförståelse i målspråket och vad som påverkar processen. Målet är att ni genom att arbeta med den här delen ska öka era kunskaper om vad som ligger bakom elevernas utma

We study performance limitations of distributed feedback control in large-scale networked dynamical systems. Specifically, we address the question of how the performance of distributed integral control is affected by measurement noise. We consider second-order consensus-like problems modeled over a toric lattice network, and study asymptotic scalings (in network size) of H2 performance metrics tha

Distributed approaches to secondary frequency control have become a way to address the need for more flexible control schemes in power networks with increasingly distributed generation. The distributed averaging proportional-integral (DAPI) controller presents one such approach. In this paper, we analyze the transient performance of this controller, and specifically address the question of its per

We consider frequency control of synchronous generator networks and study transient performance under both primary and secondary frequency control. We model random step changes in power loads and evaluate performance in terms of expected deviations from a synchronous frequency over the synchronization transient; what can be thought of as lack of frequency coherence. We compare a standard droop con

We consider distributed control of double-integrator networks, where agents are subject to stochastic disturbances. We study performance of such networks in terms of coherence, defined through an H2 norm metric that represents the variance of nodal state fluctuations. Specifically, we address known performance limitations of the standard consensus protocol, which cause this variance to scale unbou

In this paper, we compare the transient performance of a multi-terminal high-voltage DC (MTDC) grid equipped with a slack bus for voltage control to that of two distributed control schemes: A standard droop controller and a distributed averaging proportional-integral (DAPI) controller. We evaluate performance in terms of an ℋ2 metric that quantifies expected deviations from nominal voltages, and s

We apply an operator-theoretic viewpoint to a class of non-smooth dynamical systems that are exposed to event-triggered state resets. The considered benchmark problem is that of a pendulum which receives a downward kick at certain fixed angles. The pendulum is modeled as a hybrid automaton and is analyzed from both a geometric perspective and the formalism of Koopman operator theory. A connection