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The life expectancy for pancreatic cancer patients has seen no substantial changes in the last 40 years as very few and mostly just palliative treatments are available. As the five years survival rate remains around 5%, the identification of novel pharmacological targets and development of new therapeutic strategies are urgently needed. Here we demonstrate that inhibition of the G protein-coupled

Aging negatively affects hematopoiesis, with consequences for immunity and acquired blood cell disorders. Although impairments in hematopoietic stem cell (HSC) function contribute to this, the in vivo dynamics of such changes remain obscure. Here, we integrate extensive longitudinal functional assessments of HSC-specific lineage tracing with single-cell transcriptome and epitope profiling. In cont

Remediation of soil contaminated with cadmium (Cd) and lead (Pb) is critical for tobacco production. Silicon (Si) fertilizer can relieve heavy metal stress and promote plant growth, however, it remains unknown whether fertilization with Si can mitigate the effects of Cd and Pb on tobacco growth and alter microbial community composition in polluted soils. Here we assessed the effect of two organic

The central nervous system coordinates movement through forces generated by motor units (MUs) in skeletal muscles. To analyze MUs function is essential in sports, rehabilitation medicine applications, and neuromuscular diagnostics. The MUs and their function are studied using electromyography. Typically, these methods study only a small muscle volume (1 mm3) or only a superficial (

Acute respiratory distress syndrome (ARDS) is a life-threatening condition with mortality rates between 30-50%. Although in vitro models replicate some aspects of ARDS, small and large animal models remain the primary research tools due to the multifactorial nature of the disease. When using these animal models, histology serves as the gold standard method to confirm lung injury and exclude other

En populärvetenskaplig artikel som beskriver Lunds studentkårers stora och lilla standar och deras historia, samt försöker sätta dem i en historisk kontext.

The aim of this master thesis is to investigate how public libraries through projects work to include the target group youth/young adults. To get an understanding of this I will examine five projects towards youth/young adults at public libraries in Skåne. The theoretical framework I have used is the four-space model. The method being used is an ethnographic content analysis of documents from the

The return of cultural property (also known as repatriation or restitution) is a process that is increasing at Swedish museums in the 21st century. Many objects have been returned to their country of origin and their individual journey have been well researched. However, research focusing on institutional changes at the museums, from which the objects have been returned, has not been given the sam

Skeletal muscles are functionally regulated by populations of so-called motor units (MUs). An MU comprises a bundle of muscle fibers controlled by a neuron from the spinal cord. Current methods to diagnose neuromuscular diseases and monitor rehabilitation, and study sports sciences rely on recording and analyzing the bio-electric activity of the MUs. However, these methods provide information from

During the past years, activist movements have increasingly turned to social media to raise awareness and critically discuss current development and future scenarios. As a contribution to the discussion of new social movements and activism in the digital age, this study aims to explore and critically discuss how environmental risks and crisis are visually communicated in activism campaigns on Inst

Numerous location-based services (LBS) have evolved because of the fast development of mobile Internet for use in commerce, entertainment, security, and other areas. All of these need a precise real-time location-based service with smooth indoor- outdoor transition in highly populated areas. A truly omnipresent location system for both indoor and outdoor settings is still not accessible, despite t

Most recent programming languages, such as Java, Python and Ruby, include a collection framework as part of their standard library (or runtime). The Java Collection Framework provides a number of collection classes, some of which implement the same abstract data type, making them interchangeable. Developers can therefore choose between several functionally equivalent options. Since collections hav

Several plasticizing chemicals induce endocrine disrupting effects in humans, and the indoor environment is suggested to be a source of exposure. As children are particularly vulnerable to the effects from exposure to endocrine disrupting chemicals (EDCs), it is essential to monitor exposure to EDCs such as phthalates and non-phthalate plasticizers in indoor environments intended for use by childr

Hos patienter med medelsvår/svår långvarig icke-malign smärta är två av fem patienter förskrivna opioida läkemedel vid undersökning 2015–2017 vilket inte ligger i linje med aktuella behandlingsriktlinjer som avråder från långvariga behandlingar med opioida läkemedel då behandlingsnytta är oklar och risker väl belagda.

Three orthogonal techniques were used to provide new insights into thermally induced aggregation of the therapeutic protein Somatropin at pH 5.8 and 7.0. The techniques were Dynamic Light Scattering (DLS), Asymmetric Flow-Field Flow-Fractionation (AF4), and the TEM-based analysis system MiniTEM™. In addition, Differential Scanning Calorimetry (DSC) was used to study the thermal unfolding and stabi

Intact forests and protected areas (PAs) are central to global biodiversity conservation and nature-based climate change mitigation. However, cropland encroachment threatens the ecological integrity and resilience of their functioning. Using satellite observations, we find that a large proportion of croplands in the remaining forests globally have been gained during 2003–2019, especially for high-

Studying how small quantum systems, like molecules and clusters, interact with X-rays is crucial to understanding the ultrafast processes that occur in nature on incredibly short timescales, ranging from femtoseconds to picoseconds. X-rays excite small quantum systems to unstable core hole states, leading to a cascade of phenomena, including Auger decay, nuclear rearrangement, and dissociation. Th